Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

Silva, Cláudia Maria da; Belo, Andrezza V.; Andrade, Sílvia Passos; Campos, Paula Peixoto; Ferreira, Mariana Costa; Silva-Filho, Agnaldo L.; Carneiro, Márcia Mendonça

doi:10.1016/j.biopha.2014.08.005

Cited by 28 publications

(24 citation statements)

References 58 publications

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“…Role neutrophil in infected endometrioma was not only eliminate bacteria but also proving endometriosis cell to grow. In this study neutrophil level was increasing 77.05+15.15 compared in endometriosis only 67.75+9.37.One study reveled level of the neutrophil in endometriosis was 4.14+1.73 103/uL) and this correspond to this study [12,13,14,16].…”

Section: Discussionsupporting

confidence: 82%

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Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Surya¹,

Harzif²,

Maidarti³

et al. 2017

Kme

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Section: Discussionsupporting

confidence: 82%

“…Role of basophil and eosinophil still contradiction. In this study showed response of the basophil and eosinophil was not different in infected endometrioma and endometrioma [10,15,16,20,21].…”

Section: Discussionmentioning

confidence: 56%

Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Surya¹,

Harzif²,

Maidarti³

et al. 2017

Kme

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“…Other investigators focused on MPO levels in peritoneal [14], follicular [26], or menstrual [27] fluid, measuring only total MPO levels [14] or MPO activity [26,27] (not specific MPO activity). Riley et al [14] found decreased total MPO levels in the peritoneal fluid of stage I endometriosis patients indicating an initially reduced inflammatory neutrophil response, which becomes stronger as the disease progresses.…”

Section: Discussionmentioning

confidence: 99%

“…As a marker of inflammation, MPO might serve as a potential noninvasive biomarker of endometriosis [25]. Data regarding the MPO level in peripheral blood of endometriosis patients are relatively scarce and large sample datasets are lacking (n = 17; 38; 58) [26][27][28]. Furthermore, these studies investigated only the activity of MPO, but no total MPO levels [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

“…Data regarding the MPO level in peripheral blood of endometriosis patients are relatively scarce and large sample datasets are lacking (n = 17; 38; 58) [26][27][28]. Furthermore, these studies investigated only the activity of MPO, but no total MPO levels [26][27][28]. Therefore, our study was done in a large number of subjects (n = 333) to test the hypothesis that total, active, and specific levels of MPO are significantly altered in plasma of women with endometriosis compared to women without endometriosis.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Total, Active, and Specific Myeloperoxidase Levels in Women with and without Endometriosis

Waelkens

Peterse

et al. 2017

Gynecol Obstet Invest

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Myeloperoxidase (MPO) is a proinflammatory enzyme and a marker for neutrophil activation and oxidative stress. Since oxidative stress and inflammation are linked to the pathogenesis of endometriosis, we hypothesized that the total, active, and specific (active/total) MPO levels were significantly different in plasma of women with and without endometriosis. Samples were selected from our biobank from women with endometriosis (n = 212) and controls without endometriosis (n = 121) across the menstrual cycle. Total MPO plasma levels were measured by immunoassay and MPO activity by enzymatic assay. Total and active MPO levels did not differ significantly among endometriosis cases and controls, whereas the specific MPO activity was significantly lower in women with endometriosis than that in controls (p = 0.0159). After the subdivision of control patients into women with a normal pelvis and women with other benign gynecological disorders, a significant difference was observed only between women with endometriosis and women with other benign gynecological disorders (p = 0.0266). In conclusion, systemic MPO levels may not be suited as a single biomarker for endometriosis. Our data support the involvement of MPO in other gynecological disorders but do not provide any evidence for an association with endometriosis.

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Endometrial biomarkers for the non-invasive diagnosis of endometriosis

Gupta

Hull

Fraser

et al. 2016

Cochrane Database of Systematic Reviews

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We could not statistically evaluate most of the biomarkers assessed in this review in a meaningful way. In view of the low quality of most of the included studies, the findings of this review should be interpreted with caution. Although PGP 9.5 met the criteria for a replacement test, it demonstrated considerable inter study heterogeneity in diagnostic estimates, the source of which could not be determined. Several endometrial biomarkers, such as endometrial proteome, 17βHSD2, IL-1R2, caldesmon and other neural markers (VIP, CGRP, SP, NPY and combination of VIP, PGP 9.5 and SP) showed promising evidence of diagnostic accuracy, but there was insufficient or poor quality evidence for any clinical recommendations. Laparoscopy remains the gold standard for the diagnosis of endometriosis, and using any non-invasive tests should only be undertaken in a research setting. We have also identified a number of biomarkers that demonstrated no diagnostic value for endometriosis. We recommend that researchers direct future studies towards biomarkers with high diagnostic potential in good quality diagnostic studies.

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Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

Cited by 28 publications

References 58 publications

Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Expression of CA-125 Level And Neutrophil to Lymphocyte Ratio In Infected And Non-infected Endometrioma

Evaluation of Total, Active, and Specific Myeloperoxidase Levels in Women with and without Endometriosis

Endometrial biomarkers for the non-invasive diagnosis of endometriosis

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