Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

Shlivko, I. L.; Kirillin, Mikhail; Донченко, Е. В.; Ellinsky, D. O.; Garanina, Oksana; Neznakhina, M.S.; Агрба, П. Д.; Kamensky, Vladislav A.

doi:10.1111/srt.12209

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…/s is the thermal di®usivity of the medium 16 ), equals 300-400 m, which is more than the penetration depth of the incident radiation l $ 1= scat $ 100 m. Hence, the localization region of the energy released as a result of the exposure to laser radiation is determined by the thermal di®usivity length. When a coated¯ber is used, 20% of the radiation energy is released immediately on the tissue surface.…”

Section: Discussionmentioning

confidence: 99%

“…Let us take as an example a 500 m thick layer with a characteristic scattering coe±cient of 120 cm À1 and an average scattering cosine of 0.9, which corresponds to the known average values for human skin. 16 As the exact value of the absorption coe±cient is not known, we will consider a possible range of 0.14-8 cm À1 for the values. [17][18][19] Let us consider a case where the radiation being input through the front face of the sample in direct contact with a silica¯ber (n ¼ 1:49) 320 m in diameter, and suppose that The¯eld intensity distribution along the sample depth at a point r ¼ 0 is presented in Fig.…”

Section: Discussionmentioning

confidence: 99%

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The influence on biotissue laser resection of a strongly absorbing layer at the optical fiber tip

Kuznetsova

Elagin

Karabut

et al. 2016

J. Innov. Opt. Health Sci.

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In this paper, we consider a method of laser resection using the silica glass core from which the cladding layer has been removed as the cutting part of a laser scalpel. An absorbing layer coating the silica¯ber tip markedly alters its biotissue cutting characteristics. The results of histological studies of skin after exposure to a laser scalpel with and without a strongly absorbing coating (SAC) at a wavelength of 0.97 m show that resection using a coated scalpel is more sparing. When an uncoated scalpel was used, skin injury was more apparent in both its surface spread and the depth of structural damage, resulting in poorer tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The influence on biotissue laser resection of a strongly absorbing layer at the optical fiber tip

Kuznetsova

Elagin

Karabut

et al. 2016

J. Innov. Opt. Health Sci.

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show abstract

“…The other major approach is based on MC simulation. This approach simulates directly the interaction between photons and tissues during light transport within the tissue . Given the optical geometry and optical properties of a tissue model, photons are simulated and tracked along their path through the tissue subject to stochastic events of absorption and scattering.…”

Section: Related Workmentioning

confidence: 99%

“…This approach simulates directly the interaction between photons and tissues during light transport within the tissue. [6][7][8] Given the optical geometry and optical properties of a tissue model, photons are simulated and tracked along their path through the tissue subject to stochastic events of absorption and scattering. Wang et al 9 developed a simulator, namely, the MCML, for studying the propagation of a laser beam incident to multilayered tissues.…”

Section: Related Workmentioning

confidence: 99%

Accurate Monte Carlo simulation of frequency‐domain optical coherence tomography

Wang

Bai

2019

Numer Methods Biomed Eng

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Optical coherence tomography (OCT) relies on optical interferometry to provide noninvasive imaging of living tissues. In addition to its 3D imaging capacity for medical diagnosis, its potential use for recovering optical parameters of biological tissues for biological and pathological analyses has also been explored by researchers, as pathological changes in tissue alter the microstructure of the tissue and therefore its optical properties. We aim to develop a new approach to OCT data analysis by estimating optical properties of tissues from OCT scans, which are invisible in the scans. This is an inverse problem. Solving an inverse problem involves a forward modeling step to simulate OCT scans of the tissues with hypothesized optical parameter values and an inverse step to estimate the real optical par1meters values by matching the simulated scans to real scans. In this paper, we present a Monte Carlo (MC)–based approach for simulating the frequency‐domain OCT. We incorporated a focusing Gaussian light beam rather than an infinitesimally thin light beam for accurate simulations. A new and more accurate photon detection scheme is also implemented. We compare our MC model to an analytical OCT model based on the extended Huygens‐Fresnel principle (EHF) to demonstrate the consistency between the two models. We show that the two models are in good agreement for tissues with high scattering and high anisotropy factors.

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“…However, it is the viable epidermis, or more specifically, the stratum spinosum where most of the OCT signal is generated from beneath the skin surface [4][5][6]. The viable epidermis is interdigitated with the papillary layer and is at a similar depth, which could explain the confusion.…”

Section: Subsurface Fingerprintsmentioning

confidence: 99%

Fast subsurface fingerprint imaging with full-field optical coherence tomography system equipped with a silicon camera

Auksorius

Boccara

2017

J. Biomed. Opt

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Images recorded below the surface of a finger can have more details and be of higher quality than the conventional surface fingerprint images. This is particularly true when the quality of the surface fingerprints is compromised by, for example, moisture or surface damage. However, there is an unmet need for an inexpensive fingerprint sensor that is able to acquire high-quality images deep below the surface in short time. To this end, we report on a cost-effective full-field optical coherent tomography system comprised of a silicon camera and a powerful near-infrared LED light source. The system, for example, is able to record 1.7 cm×1.7 cmen face images in 0.12 s with the spatial sampling rate of 2116 dots per inch and the sensitivity of 93 dB. We show that the system can be used to image internal fingerprints and sweat ducts with good contrast. Finally, to demonstrate its biometric performance, we acquired subsurface fingerprint images from 240 individual fingers and estimated the equal-error-rate to be ∼0.8%. The developed instrument could also be used in other en face deep-tissue imaging applications because of its high sensitivity, such as in vivo skin imaging.

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Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

Abstract: The revealed differences in the structure of horny and cellular layers of epidermis, as well as of papillary and reticular dermis in skin with thin and thick epidermis specify different optical properties of these layers in OCT images.

Cited by 13 publications

References 25 publications

The influence on biotissue laser resection of a strongly absorbing layer at the optical fiber tip

The influence on biotissue laser resection of a strongly absorbing layer at the optical fiber tip

Accurate Monte Carlo simulation of frequency‐domain optical coherence tomography

Fast subsurface fingerprint imaging with full-field optical coherence tomography system equipped with a silicon camera

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