Identification of <i>Mycobacterium tuberculosis</i> and non‐tuberculous mycobacteria from cutaneous sarcoidosis lesions by reverse blot hybridization assay

Lee, Hanil; Eom, Minseob; Kim, Sang-Ha; Wang, Hye Young; Lee, Hyeyoung; Choi, Eung Ho

doi:10.1111/1346-8138.15042

Cited by 14 publications

(9 citation statements)

References 15 publications

(40 reference statements)

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“…; in several studies, mycobacterial DNA similar to those of M. tuberculosis , M. avium, M. kansasii , and M. marinum was detected in approximately one to two-thirds of sarcoidosis cases, although bacterial bodies of Mycobacterium spp. were not detected [ 1 , 8 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. Another important candidate is C. acnes (formerly Propionibacterium acnes ), which is the only microorganism to be isolated from sarcoidal lesions [ 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Novel Surrogate Histologic Findingsmentioning

confidence: 99%

Histology of Cardiac Sarcoidosis with Novel Considerations Arranged upon a Pathologic Basis

Kato

Sakai

Okabe

et al. 2022

JCM

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Sarcoidosis is a rare disease of isolated or diffuse granulomatous inflammation. Although any organs can be affected by sarcoidosis, cardiac sarcoidosis is a fatal disorder, and it is crucial to accurately diagnose it to prevent sudden death due to dysrhythmia. Although endomyocardial biopsy is invasive and has limited sensitivity for identifying granulomas, it is the only modality that yields a definitive diagnosis of cardiac sarcoidosis. It is imperative to develop novel pathological approaches for the precise diagnosis of cardiac sarcoidosis. Here, we aimed to discuss commonly used diagnostic criteria for cardiac sarcoidosis and to summarize useful and novel histopathologic criteria of cardiac sarcoidosis. While classical histologic observations including noncaseating granulomas and multinucleated giant cells (typically Langhans type) are the most important findings, others such as microgranulomas, CD68+ CD163− pro-inflammatory (M1) macrophage accumulation, CD4/CD8 T-cell ratio, Cutibacterium acnes components, lymphangiogenesis, confluent fibrosis, and fatty infiltration may help to improve the sensitivity of endomyocardial biopsy for detecting cardiac sarcoidosis. These novel histologic findings are based on the pathology of cardiac sarcoidosis. We also discussed the principal histologic differential diagnoses of cardiac sarcoidosis, such as tuberculosis myocarditis, fungal myocarditis, giant cell myocarditis, and dilated cardiomyopathy.

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Section: Novel Surrogate Histologic Findingsmentioning

confidence: 99%

Histology of Cardiac Sarcoidosis with Novel Considerations Arranged upon a Pathologic Basis

Kato

Sakai

Okabe

et al. 2022

JCM

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“…Meanwhile, it is believed that the allergic condition of the patients to certain pathogens plays an important role in granulomatous disease, including sarcoidosis. Various pathogens, such as mycobacteria [15][16][17], mumps virus [18], and human herpes viruses [19] have been listed as candidates for sarcoidosis. While mycobacteria are regarded as an important candidate causative pathogen of sarcoidosis, especially in Western countries, Propionibacterium acnes (P. acnes), currently reclassified as Cutibacterium acnes, has been investigated as the causative agent of sarcoidosis in Japanese groups.…”

Section: Etiological Studies Of Systemic Sarcoidosismentioning

confidence: 99%

Characteristics and management of ocular sarcoidosis

Takase

2021

Immunological Medicine

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Sarcoidosis is a chronic inflammatory disease of unknown etiology that affects many systemic organs, including the eye. The eye is the second most frequently affected organ in patients with sarcoidosis after lung disease. Approximately 30-50% of patients with systemic sarcoidosis develop uveitis, which is a sight-threatening intraocular inflammatory disorder. Sarcoidosis is the leading cause of uveitis in Japan and is one of the major clinical entities in many countries. Therefore, uveitis in association with sarcoidosis (ocular sarcoidosis) is considered essential in clinical practice in ophthalmology. The current review focuses on distinguishing features of ocular sarcoidosis, diagnosis, management, and discussion of the etiology of ocular sarcoidosis.

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“…Two meta-analyses of studies evaluating potential infectious diseases that may cause sarcoidosis suggested an etiologic link between mycobacteria and sarcoidosis [123,124]. Molecular techniques have identified mycobacterial components in sarcoidosis tissues in some [125][126][127] but not all [128,129] analyses. In particular, mycobacteria catalase-peroxidase protein (mKatG) has been implicated as associated with sarcoidosis in numerous reports.…”

Section: Risk Factor Exposure/occupation Location And/or Study Population Referencementioning

confidence: 99%

A Primer on the Clinical Aspects of Sarcoidosis for the Basic and Translational Scientist

Judson

2021

JCM

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The immunopathogenesis of sarcoidosis remains unclear. This failure in understanding has been clinically impactful, as it has impeded the accurate diagnosis, treatment, and prevention of this disease. Unraveling the mechanisms of sarcoidosis will require input from basic and translational scientists. In order to reach this goal, scientists must have a firm grasp of the clinical aspects of the disease, including its diagnostic criteria, the immunologic defects, clinical presentations, response to therapy, risk factors, and clinical course. This manuscript will provide an overview of the clinical aspects of sarcoidosis that are particularly relevant for the basic and translational scientist. The variable phenotypic expression of the disease will be described, which may be integral in identifying immunologic disease mechanisms that may be relevant to subgroups of sarcoidosis patients. Data concerning treatment and risk factors may yield important insights concerning germane immunologic pathways involved in the development of disease. It is hoped that this manuscript will stimulate communication between scientists and clinicians that will eventually lead to improved care of sarcoidosis patients.

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Identification of Mycobacterium tuberculosis and non‐tuberculous mycobacteria from cutaneous sarcoidosis lesions by reverse blot hybridization assay

Cited by 14 publications

References 15 publications

Histology of Cardiac Sarcoidosis with Novel Considerations Arranged upon a Pathologic Basis

Histology of Cardiac Sarcoidosis with Novel Considerations Arranged upon a Pathologic Basis

Characteristics and management of ocular sarcoidosis

A Primer on the Clinical Aspects of Sarcoidosis for the Basic and Translational Scientist

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