Identification of hydroxylcinnamoyl tartaric acid esters in Bidens pilosa by UPLC-tandem mass spectrometry

Khoza, B. S.; Gbashi, Sefater; Steenkamp, Paul A.; Njobeh, Patrick Berka; Madala, Ntakadzeni E.

doi:10.1016/j.sajb.2015.08.018

Cited by 40 publications

(26 citation statements)

References 32 publications

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“…Salvianic acid A (n.2) [25] was discriminated from its isomers syringic acid and ethyl gallate on the basis of different fragmentation profiles [24]. Fertaric acid (n.5) was identified by comparing our results to the fragmentation profile proposed by Lee and Scagel in basil leaf [7], i.e., 325 → 282, 193, 149 m/z, and to that proposed by Khoza et al [26], i.e., 325 → 193, 149, 134 m/z. Most likely, these differences were due to a different collision energy during the MS/MS experiments.…”

Section: Identification and Quantification Of Individual (Poly)phenolsupporting

confidence: 52%

“…Moreover, it was possible to identify other classes of flavonoids. Quercetin derivatives (n. 19,20,25,26) were assigned by combining information related to the m/z of the precursor with the presence of the ion at 303.05 m/z (quercetin aglycon) in the fragmentation profile [30,32]. In the case of quercetin malonyl Glc Glc (n.20), loss of the malonylglucoside moiety (713.16-248.05 → 465.11, corresponding to quercetin glucoside) was also detected.…”

Section: Identification and Quantification Of Individual Flavonoidsmentioning

confidence: 99%

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Insight into Composition of Bioactive Phenolic Compounds in Leaves and Flowers of Green and Purple Basil

Prinsi

Morgutti

Negrini

et al. 2019

Plants

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Basil (Ocimum basilicum L.) is a culinary, medicinal, and ornamental plant appreciated for its antioxidant properties, mainly attributed to high content of rosmarinic acid. This species also includes purple varieties, characterized by the accumulation of anthocyanins in leaves and flowers. In this work, we compared the main morphological characteristics, the antioxidant capacity and the chemical composition in leaves, flowers, and corollas of green (‘Italiano Classico’) and purple (‘Red Rubin’ and ‘Dark Opal’) basil varieties. The LC-ESI-MS/MS analysis of individual compounds allowed quantifying 17 (poly)phenolic acids and 18 flavonoids, differently accumulated in leaves and flowers of the three varieties. The study revealed that in addition to rosmarinic acid, basil contains several members of the salvianolic acid family, only scarcely descripted in this species, as well as, especially in flowers, simple phenolic acids, such as 4-hydroxybenzoic acid and salvianic acid A. Moreover, the study revealed that purple leaves mainly contain highly acylated anthocyanins, while purple flowers accumulate anthocyanins with low degree of decoration. Overall, this study provides new biochemical information about the presence of not yet characterized bioactive compounds in basil that could contribute to boosting the use of this crop and to gaining new knowledge about the roles of these compounds in plant physiology.

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Section: Identification and Quantification Of Individual (Poly)phenolsupporting

confidence: 52%

Section: Identification and Quantification Of Individual Flavonoidsmentioning

confidence: 99%

Insight into Composition of Bioactive Phenolic Compounds in Leaves and Flowers of Green and Purple Basil

Prinsi

Morgutti

Negrini

et al. 2019

Plants

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“…Peaks 8 and 9 may correspond to its two other diastereoisomers, D-chicoric acid and meso-chicoric acid described by Buiarelli et al (2010) and Carazzone et al (2013). Similarly to Khoza et al (2016), we observed that the fragmentation pattern of the three isomers is tightly similar in electrospray ionization conditions. Peak 9 was attributed to the meso isomer because of its lower amount of fragment m/z 293 previously described (Llorach et al, 2008).…”

Section: Chemical Analysis Of Ncrae Content (Table 1 and 2)mentioning

confidence: 52%

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

Ferrare

Bidel

Awwad

et al. 2018

Journal of Ethnopharmacology

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Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect, Journal of Ethnopharmacology, https://doi.org/10. 1016/j.jep.2017.12.035 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACT Ethnopharmacological relevance Chicory (Cichorium intybus L.) is an indigenous vegetable widely cultivated in Europe,America and Asia. In ancient times, the leaves, flowers, seeds, and roots have been used as a wealth of health benefits including its tonic effects, the ability to ease digestive problems and to detoxify liver. In Indian traditional therapy, chicory was known to possess antidiabetic effect. In the traditional medicine of Bulgaria and Italy, chicory was used as hypoglycemic decoctions. Aims of the studiesWe wanted to obtain the complete chemical composition of the natural chicoric acid extract (NCRAE), a chicory root extract rich in chicoric acid, which previously showed its glucose tolerance effect in normal rats. To investigate if the whole NCRAE is required to be effective, we performed a comparative in vivo experiment on STZ diabetic rats treated either with NCRAE or a mixture composed of the two major compounds of NCRAE. Materials and Methods1 K. Ferrare and L.P.R. Bidel contributed equally to this study. ResultsThe LC-MS analysis confirmed the high abundance of chicoric acid (64.2%) in NCRAE and a second part of NCRAE is composed of caffeoylquinic acids (CQAs) at 19.6% with among them the chlorogenic acid. This result has permitted us to prepare a mixture of synthetic Lchicoric acid (70%) and synthetic chlorogenic acid (30%): the solution is designated SCCAM.Our results showed that both NCRAE and SCCAM are able to improve a glucose tolerance in STZ diabetic rats after a subchronic administration of seven days. Alone NCRAE allows to significantly decrease the basal hyperglycemia after six days of treatment. In vivo experiments on streptozotocin Chicoric acid 72.4 % Caffeoyl-quinic acids 19.6 % NCRAE contained a mixture of CRA, CGA and others caffeoyl derivatives that confer this antidiabetic -NCRAE induced a antidiabetic effect, -SCCAM induced an glucose

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“…During extraction with subcritical water, the fluid can be maneuvered to selectively extract a range of analytes with different polarities by mere adjusting the temperature of the water, whereas SFE extracts only nonpolar or light-weight compounds [90,112]. Further to this, SWE is very compatible with various analytical instrumentations because water is colorless and may not interfere with sorts of photodetection such as UV detection or flame ionization detection [14,116].…”

Section: Advantages Of Subcritical Water Extractionmentioning

confidence: 99%

Subcritical Water Extraction and Its Prospects for Aflatoxins Extraction in Biological Materials

Gbashi¹,

Madala²,

AyodejiAdebo³

et al. 2017

Aflatoxin-Control, Analysis, Detection and Health Risks

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Aflatoxins (AFs) are well-known mycotoxins and contaminants of various agricultural commodities globally that are linked to a wide range of adverse health and economic complications. Because of their incessant proliferation and deleterious consequences, it has become mandatory to routinely monitor the levels of these toxins in agricultural products before they go into the market. Essentially, effective analysis is an important component of AFs control, and extraction is a necessary step for their analysis, irrespective of the protocol adopted. Conventional methods for AF extraction are expensive, the processes involved are tedious and utilize large quantities of organic solvents that are environmentally unfriendly. This has necessitated the quest for alternatives that are 'green', cost-effective and easy to perform. In this regard, subcritical water extraction (SWE) is a viable alternative that has proven to be effective in the extraction of other bioactive compounds. This chapter presents a critical appraisal of the principles and dynamics of SWE, and its current applications as a viable tool in the extraction of AFs from various biological matrices. Although further research needs to be performed to enhance its applicability, the adoption of SWE in the extraction of AFs seems very promising and needs to be properly exploited.

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Identification of hydroxylcinnamoyl tartaric acid esters in Bidens pilosa by UPLC-tandem mass spectrometry

Cited by 40 publications

References 32 publications

Insight into Composition of Bioactive Phenolic Compounds in Leaves and Flowers of Green and Purple Basil

Insight into Composition of Bioactive Phenolic Compounds in Leaves and Flowers of Green and Purple Basil

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

Subcritical Water Extraction and Its Prospects for Aflatoxins Extraction in Biological Materials

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