Identification of High-Risk Coronary Lesions by 3-Vessel Optical Coherence Tomography

Jiang, Shuang; Fang, Chao; Xu, Xueming; Liu, Xing; Sun, Sibo; Peng, Cong; Yin, Yan-Wei; Lei, Fangmeng; Wang, Yini; Li, Lulu; Chen, Yuzhu; Pei, Xueying; Jia, Ruyi; Tang, Caiying; Song, Li; Li, Shuang; Hou, Yu; Chen, Tao; Tan, Jinfeng; Liu, Xiaohui; Hou, Jingbo; Dai, Jihong; Yu, Bo

doi:10.1016/j.jacc.2023.01.030

Cited by 16 publications

(6 citation statements)

References 25 publications

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“…Associations between retina vascular features and CVD were first demonstrated with fundus photographs [4,5]. These associations were subsequently confirmed with other retinal imaging such as retinal swept source optical coherence tomography angiography (SS OCT-A) [6,7]. SS OCT-A enables the noninvasive assessment of the retinal microvascular network.…”

Section: Discussionmentioning

confidence: 82%

A Retinal Oct-Angiography and Cardiovascular STAtus (RASTA) Dataset on Swept-Source Microvascular Imaging for Cardiovascular Risk Assessment

Germanèse,

Meriaudeau,

Eid

et al. 2023

Preprint

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In a context of exponential demographic growth, the imbalance between human resources and public health problems is impelling us to envision other solutions to the difficulties faced in the diagnosis, prevention and large-scale management of the most common diseases. Cardiovascular diseases represent the leading cause of morbidity and mortality worldwide. A large-scale screening program would make it possible to promptly identify patients with high cardiovascular risk in order to manage them adequately. Optical coherence tomography-angiography (OCT-A), as a window into the state of the cardiovascular system, is a rapid, reliable, and reproducible imaging examination that enables prompt identification of at-risk patients through the use of automated classification models. One challenge that limits the development of computer-aided diagnostic programs is the small number of open-source OCT-A acquisitions available. To facilitate the development of such models, we have assembled a set of images of the retinal microvascular system from 499 patients. It consists of 814 angiocubes as well as 2005 en face images. Angiocubes were captured with a swept-source OCT-A device of patients with varying overall cardiovascular risk. To the best of our knowledge, our dataset, RASTA, is the only publicly available dataset comprising such a variety of images from healthy and at-risk patients. This dataset will enable the development of generalizable models for screening of cardiovascular diseases from OCT-A retinal images.

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Section: Discussionmentioning

confidence: 82%

A Retinal Oct-Angiography and Cardiovascular STAtus (RASTA) Dataset on Swept-Source Microvascular Imaging for Cardiovascular Risk Assessment

Germanèse,

Meriaudeau,

Eid

et al. 2023

Preprint

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“…They reported that TCFA and a minimum lumen area of <3.5 mm 2 were predictive of adverse cardiac events in both lesion-level and patient-level analyses, and, when these 2 factors were present, the HR for lesion-specific analysis was 15.5 (95% CI: 6.89-34.89). 66 These OCT-based studies consistently showed that TCFA/lipid-rich plaque with a small minimum lumen area was the hallmark of adverse events. Vulnerable features have been identified by various imaging modalities, which typically include lipid-laden plaque characteristics, a small lumen area, and a large plaque burden.…”

Section: Oct As a Research Toolmentioning

confidence: 89%

“… 65 The COMBINE OCT-FFR (Combined Optical Coherence Tomography Morphologic and Fractional Flow Reserve Hemodynamic Assessment of Non-Culprit Lesions to Better Predict Adverse Event Outcomes in Diabetes Mellitus Patients) trial demonstrated that, among lesions with a negative FFR (>0.80), TCFA more frequently developed adverse cardiac events. 65 More recently, Jiang et al 66 investigated 883 patients with AMI who underwent OCT examination of all 3 main epicardial coronary arteries after primary PCI. They reported that TCFA and a minimum lumen area of <3.5 mm 2 were predictive of adverse cardiac events in both lesion-level and patient-level analyses, and, when these 2 factors were present, the HR for lesion-specific analysis was 15.5 (95% CI: 6.89-34.89).…”

Section: Oct As a Research Toolmentioning

confidence: 99%

Cardiac Optical Coherence Tomography

Yonetsu,

Jang

2024

JACC: Asia

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“…CCTA can be used as a prognostic tool to characterise calcified and non-calcified plaques, the latter of which may be present in young people and may even indicate greater plaque vulnerability and risk of complications [95,96]. It is also indicated in symptomatic patients, as one of its main advantages is that it detects obstructive lesions and allows the measurement of the stenosis degree.…”

Section: Coronary Computed Tomography Angiography (Ccta)mentioning

confidence: 99%

Screening for Subclinical Atherosclerosis and the Prediction of Cardiovascular Events in People with Type 1 Diabetes

Serés-Noriega,

Perea,

Amor

2024

JCM

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People with type 1 diabetes (T1D) have a high cardiovascular disease (CVD) risk, which remains the leading cause of death in this population. Despite the improved control of several classic risk factors, particularly better glycaemic control, cardiovascular morbidity and mortality continue to be significantly higher than in the general population. In routine clinical practice, estimating cardiovascular risk (CVR) in people with T1D using scales or equations is often imprecise because much of the evidence comes from pooled samples of people with type 2 diabetes (T2D) and T1D or from extrapolations of studies performed on people with T2D. Given that T1D onsets at a young age, prolonged exposure to the disease and its consequences (e.g., hyperglycaemia, changes in lipid metabolism or inflammation) have a detrimental impact on cardiovascular health. Therefore, it is critical to have tools that allow for the early identification of those individuals with a higher CVR and thus be able to make the most appropriate management decisions in each case. In this sense, atherosclerosis is the prelude to most cardiovascular events. People with diabetes present pathophysiological alterations that facilitate atherosclerosis development and that may imply a greater vulnerability of atheromatous plaques. Screening for subclinical atherosclerosis using various techniques, mainly imaging, has proven valuable in predicting cardiovascular events. Its use enables the reclassification of CVR and, therefore, an individualised adjustment of therapeutic management. However, the available evidence in people with T1D is scarce. This narrative review provides and updated overview of the main non-invasive tests for detecting atherosclerosis plaques and their association with CVD in people with T1D.

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Identification of High-Risk Coronary Lesions by 3-Vessel Optical Coherence Tomography

Cited by 16 publications

References 25 publications

A Retinal Oct-Angiography and Cardiovascular STAtus (RASTA) Dataset on Swept-Source Microvascular Imaging for Cardiovascular Risk Assessment

A Retinal Oct-Angiography and Cardiovascular STAtus (RASTA) Dataset on Swept-Source Microvascular Imaging for Cardiovascular Risk Assessment

Cardiac Optical Coherence Tomography

Screening for Subclinical Atherosclerosis and the Prediction of Cardiovascular Events in People with Type 1 Diabetes

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