Identification of high responders for interleukin-6 and creatine kinase following acute eccentric resistance exercise in elderly obese women

Tajra, Vitor; Tibana, Ramires Alsamir; Vieira, Denis César Leite; Farias, Darlan Lopes de; Teixeira, Tatiane Gomes; Funghetto, Silvana Schwerz; Silva, Alessandro Oliveira; Sousa, Nuno Manuel Frade de; Willardson, Jeffrey M.; Karnikowski, Margô Gomes de Oliveira; Prestes, Jonato

doi:10.1016/j.jsams.2013.09.012

Cited by 30 publications

(37 citation statements)

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“…In addition, Machado and Willardson (2010) reported that an accepted definition of HR and LR currently does not exist in the literature, and that the mechanisms responsible for the disproportionate response in HR are not clearly understood. In fact, motivated by this finding, our research group reported that elderly individuals classified as HR experienced greater CK and interleukin-6 responses to an acute eccentric resistance exercise session (consisting of seven sets of 10 repetitions at 110 % of 10RM, with 3-min rest intervals between sets) (Tajra et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…This might explain why despite increments in muscle strength, some studies did not observe significant effects of RT on circulating BDNF (Levinger et al 2008). This is a relevant topic, because results of studies are normally discussed at the basis of group means and not by classification of responders and nonresponders, which may lead to a misleading interpretation of results (Tajra et al 2014;Garcia et al 2014;Loenneke et al 2014). Even though the presence of high and low responders should receive attention, it is not known whether such individuals can be detected for other important mediators, such as irisin, TLR-4, IL1-β, and BDNF, which play important roles in insulin resistance, inflammation, obesity (Oliveira et al 2011;Pardo et al 2014), and neuroplasticity of the brain (Coelho et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Understanding the individual responsiveness to resistance training periodization

Prestes

Nascimento

Tibana

et al. 2015

AGE

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This study was designed to compare the effects of linear periodization (LP) and undulating periodization (UP) on functional capacity, neuromuscular function, body composition, and cytokines in elderly sedentary women. We also aimed to identify the presence of high responders (HR), medium responders (MR), and low responders (LR) for irisin, interleukin-1 beta (IL-1β), toll-like receptor-4 (TLR-4), and brainderived neurotrophic factor (BDNF) to resistance training (RT). Forty-nine elderly women were assigned to a control group, LP, and UP scheme. Functional capacity, body composition, maximal strength, irisin, TLR-4, BDNF, and IL-1β were evaluated. Both periodization models were effective in improving 45°leg press 1RM, chair-stand, arm curl, and time-up and go tests, with no significant differences in body composition and cytokines. Furthermore, HR, MR, and LR were identified for irisin, IL-1β, TLR-4, and BDNF, with differences between groups and moments. This study provides evidence that both periodization models were effective in improving functional capacity and neuromuscular function, with no effect on body composition and cytokines (probably as a consequence of the different responsiveness). Furthermore, for the first time, HR, MR, and LR were identified for irisin, IL1-β, TLR-4, and BDNF in response to RT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Understanding the individual responsiveness to resistance training periodization

Prestes

Nascimento

Tibana

et al. 2015

AGE

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“…This reinforces the importance of ERE in initial resistance training routines in older adults with low levels of strength and a sedentary lifestyle (Roig et al ., ; Raj et al ., ). Interestingly, higher values of creatine kinase (CK, 361 U l −1 ) have been reported following the same ERE protocol, denoting no alarming CK responses, which could be associated with excessive muscle damage and acute rhabdomyolysis (Tajra et al ., ). ERE was chosen in the current investigation because the reserve of eccentric strength could be used, in combination with a greater magnitude of force development, allowing for a higher training intensity thus maximizing gains in muscle function in elderly subjects (Roig et al ., ).…”

Section: Discussionmentioning

confidence: 97%

“…Seven days following the 10 RM tests, subjects completed an ERE protocol as previously described (Funghetto et al ., ; Tajra et al ., ). Upon arrival to the lab, subjects began with a warm‐up on a cycle ergometer for 10 min at 60 rpm and 50 W, followed by 10 leg extension repetitions at 50% of 10 RM load, and then a rest interval of 3–5 min was allowed.…”

Section: Methodsmentioning

confidence: 97%

Acute eccentric resistance exercise decreases matrix metalloproteinase activity in obese elderly women

Nascimento

Navalta

Durigan

et al. 2014

Clin Physio Funct Imaging

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The association of ageing with obesity commits elderly women and has been correlated with multiple degenerative processes, which could be occasioned by an enhancing in levels of matrix metalloproteinase-2 and metalloproteinase-9 (MMPs) as well by an cytokine unbalance that included an enhancing on interleukin-6 (IL-6). Furthermore, other factors could be also related to degenerative process, as they could be reduced by eccentric resistance exercise (ERE), which seems particularly important to initiate resistance training in obese older adults. In this view, this study aims to determinate the effects of an acute ERE session on serum MMP-2, MMP-9 and IL-6 in elderly obese women. Ten elderly obese women participated in this study and completed a 10 repetitions maximum test (10 RM) utilizing leg extension exercise. Subjects then completed an acute ERE session consisting of seven sets of 10 repetitions at 110% of 10 RM with a rest of 3 min between sets. Blood samples were collected before, immediately after, 3, 24 and 48 h following the ERE session. Zymograms were utilized to measure the MMP-2 and MMP-9 enzymes from all individuals. Moreover, IL-6 concentration was also determinated. After ERE session, MMP-2 and MMP-9 decreased, remaining significantly below baseline values after 48 h (P<0·05). Although not statistically significant, there was a tendency for IL-6 to decrease 48 h after the ERE when compared with 3 h (P = 0·06). An acute ERE session decreases MMP-9, MMP-2 and IL-6 in elderly obese women, possibly indicating a transient protection against the low grade inflammation present in this specific population.

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“…Interestingly, elderly subjects preserve eccentric strength as compared with concentric strength, while an eccentric protocol induces lower perceived exertion and metabolic stress versus conventional resistance exercise [11], and induces no alarming creatine kinase (CK) responses in obese elderly women [11]. Changes in serum CK concentration has been previously used as an indicator of muscular damage [12], and is still used in recent studies [13].…”

Section: Introductionmentioning

confidence: 99%

Understanding responsiveness of nitric oxide to acute eccentric resistance exercise in elderly obese women

Ddc

et al. 2016

J Clin Transl Res

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Background and Aim:The aim of the present study was to examine nitrite concentration responses following eccentric resistance exercise (ERE) in elderly obese women. We also investigated the existence of high (HR) and low responders (LR) for nitrite and the possible differences with respect to creatine kinase (CK) response, metabolic and body composition variables. Methods: Forty-nine elderly obese women completed an ERE session utilizing knee extensor exercise. LR for serum nitrite were defined as a ∆nitrite ≤ 20th percentile or 24.1 µmol/L and HR as a ∆nitrite > 20th percentile. Results: Ten subjects were classified as LR and the remaining as HR (n = 39). The HR group displayed greater nitrite concentration at 0 h, 3 h, 24 h and 48 h following the ERE as compared with the LR (p < 0.05), and CK increased after 24 h and 48 h only for the HR group following the ERE (p < 0.05). Peak nitrite concentration was higher in the HR group versus the LR group (p < 0.05), while there was no difference between groups for pre-exercise nitrite values. The LR group displayed higher (p < 0.05) body fat, cholesterol, LDL and lower upper limb fat-free mass as compared with the HR group. The LR had lower (p < 0.05) upper limb fat-free mass than the HR group. Conclusions: Elderly obese women classified as HR displayed higher nitrite responses to ERE. Thus, researchers should be aware of the presence of different responsiveness of nitrite to acute exercise to avoid misinterpretation of data and to identify the higher cardiovascular risk factor of those classified as LR. Relevance for patients: The elevated NO up to 48 h following an ERE session may suggest an important protective cardiovascular effect. The higher body fat, cholesterol, LDL and lower upper limb fat-free mass in the LR group might represent a deleterious effect of lower serum levels of nitrite. Keywords:aging exercise nitric oxide synthase nitrite obesity responders

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Identification of high responders for interleukin-6 and creatine kinase following acute eccentric resistance exercise in elderly obese women

Abstract: "Identification of high responders for interleukin-6 and creatine kinase following acute eccentric resistance exercise in elderly obese women" (2014). Faculty Research and Creative Activity. 35.

Cited by 30 publications

References 27 publications

Understanding the individual responsiveness to resistance training periodization

Understanding the individual responsiveness to resistance training periodization

Acute eccentric resistance exercise decreases matrix metalloproteinase activity in obese elderly women

Understanding responsiveness of nitric oxide to acute eccentric resistance exercise in elderly obese women

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