Identification of hematopoietic progenitor cell donor characteristics predicting successful mobilization: results of an Italian multicenter study

Abstract

In healthy donors it is possible to predict successful HPC mobilization by donor sex, age, WBC count, and G-CSF form and dose. Furthermore, based on these data, it may be possible, at least in parental setting, to modulate G-CSF dosage on the basis of donor characteristics.

Prediction of hematopoietic stem cell yield after mobilization with granulocyte–colony‐stimulating factor in healthy unrelated donors

“…Vasu and colleagues reported a reduced post–G‐CSF CD34+ cell count in females in their analysis of 639 allogeneic donors. Others found the same correlation …”

“…Different variables from the blood count and clinical chemistry have been associated with the mobilization efficacy in former publications . In particular, a higher baseline PLT count was associated with increased CD34+ levels in the peripheral blood immediately before apheresis .…”

Mobilization of hematopoietic progenitor stem cells in allogeneic setting with lenograstim by subcutaneous injection, in daily or twice‐daily dosing: a single‐center prospective study with historical control

“…Published studies showed that preapheresis CD341 cell count in PB is the best predictor of CD341 cells in the apheresis products 13,16 and for the estimation of the number of procedures needed to reach the target dose. 17 In this series, we confirmed the most frequent shortterm adverse events described in other studies. 14,15 The incidence of bone pain was higher in the ODD cohort, but predominantly minor and transient and, in any case, no donor had to stop treatment.…”

Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft

“…12,[23][24][25][26][27][28] In this small cohort, the strongest predictors of higher CD34 cell mobilization were younger age, higher baseline platelet count, higher baseline circulating CD34, and higher AUC of plerixafor. Other factors associated with CD34 mobilization were CXCL12 change from baseline to 30 minutes, male gender, and a lower graft content of pDCs.…”