Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1

Cunha, Karin Soares Gonçalves

doi:10.1136/jcp.56.10.758

Cited by 34 publications

(25 citation statements)

References 29 publications

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“…Their number increases with age, and 2 major growth periods are identified – puberty and pregnancy – in the literature [6,7]. In histological studies, receptors of growth or steroid hormones have been described on cutaneous NF, reinforcing their potential role in NF growth [8]. In vitro progesterone was shown to induce a higher proliferation rate of NF1-derived Schwann cells in comparison with non-NF1 human Schwann cells [9,10].…”

Section: Discussionmentioning

confidence: 99%

Evolving Pattern with Age of Cutaneous Signs in Neurofibromatosis Type 1: A Cross-Sectional Study of 728 Patients

Duong

Bastuji‐Garin²,

Valeyrie‐Allanore

et al. 2011

Dermatology

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Background: Neurofibromatosis type 1 is fully penetrant by the age of 8 years, and 3 criteria of diagnosis are dermatological: café-au-lait spots (CLS), intertriginous freckling and neurofibromas (NF). Objectives: The aim of our study was to determine the evolving pattern of cutaneous manifestations during adulthood. Methods: Phenotypic data of patients seen in our center between March 2003 and December 2009 were studied. Patients were classified in 10-year groups. Following clinical characteristics, the number of CLS and the number of cutaneous and subcutaneous NF were compared according to age. Results: 728 subjects, 404 females and 324 males (mean age of 32.4 years, range 6–80 years) were studied. Four hundred eighty-nine patients were over 20 years old (67%). The number of CLS (small or large) was significantly decreased with age while the number of cutaneous and subcutaneous NF was strongly increased (p < 0.001). Conclusions: The decrease in CLS with age has not been previously reported while an increase in the number of NF is well described during puberty and pregnancy and with age.

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Section: Discussionmentioning

confidence: 99%

Evolving Pattern with Age of Cutaneous Signs in Neurofibromatosis Type 1: A Cross-Sectional Study of 728 Patients

Duong

Bastuji‐Garin²,

Valeyrie‐Allanore

et al. 2011

Dermatology

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“…All the cases were used in previous studies (Cunha et al 2003(Cunha et al , 2008(Cunha et al , 2009. The samples of the tumors were included in two tissue microarray (TMA) paraffin blocks.…”

Section: Samplementioning

confidence: 99%

Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

Cunha

Caruso²,

Faria³

et al. 2013

An. Acad. Bras. Ciênc.

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AIMS:To study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated. MATERIALS AND METHODS: The evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis. CONCLUSIONS: Apoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.

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“…Dermal neurofibromas had a higher frequency of being positive for progesterone receptor than plexiform neurofibromas with 86% and 50% respective positive tumors (McLaughlin and Jacks, 2003). In addition, growth hormone receptor was detected in 65% of dermal neurofibromas analyzed (Cunha et al, 2003). These studies suggest that hormones may be important in neurofibroma development.…”

Section: Aberrant Receptor Expressionmentioning

confidence: 75%

“…In support of these observations, hormone receptors have been detected in neurofibroma tissue (Cunha et al, 2003;McLaughlin and Jacks, 2003). Progesterone receptor expression was detected in 75% of neurofibromas analyzed but was not detected in normal nerve.…”

Section: Aberrant Receptor Expressionmentioning

confidence: 82%

Neurofibromatosis Type I: From Genetic Mutation to Tumor Formation

Thomas¹,

Vries²

2009

Handbook of Neurochemistry and Molecular Neurobiology

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Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1

Cited by 34 publications

References 29 publications

Evolving Pattern with Age of Cutaneous Signs in Neurofibromatosis Type 1: A Cross-Sectional Study of 728 Patients

Evolving Pattern with Age of Cutaneous Signs in Neurofibromatosis Type 1: A Cross-Sectional Study of 728 Patients

Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

Neurofibromatosis Type I: From Genetic Mutation to Tumor Formation

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