Identification of fungal candidates for asthma protection in a large population‐based study

Mueller-Rompa, Susanne; Janke, Tobias; Schwaiger, Karin; Mayer, Melanie; Bauer, Johann; Genuneit, Jon; Braun-Fahrlaender, Charlotte; Horak, Elisabeth; Boznański, Andrzej; Mutius, Erika von; Ege, Markus

doi:10.1111/pai.12665

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…Lately many studies have focused on diversity of bacterial [5][6][7], or environmental [30] exposure, but amount of exposure still seems to play a role [9] and only diversity of selected bacteria may turn out to be beneficial for asthma [8]. Few studies have conducted an untargeted search for differences in microbial content of indoor dust with the aim to explore associations with asthma [7,[31][32][33][34], and the present study is to our knowledge the first one performed in adults.…”

Section: Discussionmentioning

confidence: 93%

Indoor bacteria and asthma in adults: a multicentre case–control study within ECRHS II

et al. 2018

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Both protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation.A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays.15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs, cluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourth first quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used.In this large international study, the level of cluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.

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Section: Discussionmentioning

confidence: 93%

Indoor bacteria and asthma in adults: a multicentre case–control study within ECRHS II

et al. 2018

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“…Venero et al (2009) indicaron su posible impacto en el asma bronquial y la rinitis en escolares de La Habana. Estos géneros cuentan con gran cantidad de especies, de las cuales se destacan como causales de procesos alérgicos A. flavus, A. fumigatus, A. niger y P. citrinum (Pomés et al 2016, Roy et al 2017, Mueller-Rompa et al 2017.…”

Section: Discussionunclassified

Diversidad Fúngica en La Atmósfera De La Habana (Cuba) Durante Tres Períodos Poco Lluviosos

Espinosa

Almaguer

Ramírez

et al. 2019

Rev. Int. Contam. Ambie.

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Palabras clave: hongos, aire, alergia, estaciones RESUMEN El clima de La Habana favorece la presencia de hongos en el aire durante gran parte del año, principalmente en el horario diurno. En los períodos poco lluviosos (noviembre-abril) se evidencian las mayores variaciones climatológicas que pueden incidir en la severidad de enfermedades alérgicas y respiratorias. El objetivo de este trabajo fue caracterizar la micobiota atmosférica diurna de La Habana durante tres períodos poco lluviosos consecutivos. Se realizaron 48 muestreos volumétricos de propágulos fúngicos viables mediante un biocolector de rendija (colector chirana) durante tres períodos poco lluviosos (noviembre/2012-abril/2013, noviembre/2013-abril/2014 y noviembre/2014-abril/2015). Los hongos recolectados se aislaron e identificaron. Simultáneamente se realizó la identificación visual de esporas en las preparaciones procedentes de un captador tipo Hirst Lanzoni VPPS 2000, en el mismo día y hora de los muestreos viables. Posteriormente se calculó la concentración, densidad y frecuencia relativa de los propágulos fúngicos identificados por ambos métodos. Los períodos evaluados fueron similares de forma cuantitativa y cualitativa. Se identificaron 32 géneros fúngicos, tres sólo mediante cultivo, 17 sólo con metodología no viable y 11 con ambos sistemas de captación. También se identificaron esporas del orden Uredinales y de la familia Xylariaceae por el método no viable. Destacaron Cladosporium, Aspergillus, Penicillium, Fusarium y Curvularia por su abundancia y frecuencia relativa. La micobiota detectada en los tres períodos fue similar en diversidad y concentración de géneros. La temperatura media y la humedad relativa media se correlacionaron con las concentraciones atmosféricas de propágulos fúngicos. Los datos aportados son útiles para la prevención de alergias y enfermedades respiratorias, con alta incidencia en la población cubana en períodos invernales y secos.

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“…While some reports found no association between β-glucan in home dust and the risk for atopy [28,35], others claim it is inversely correlated to moderate to severe asthma in adults [31]. Likewise, certain fungal species and extracellular polysaccharide from Penicillum and Aspergillus species in farmer's homes have been associated with a reduced risk for asthma [28,36,37]. Presumably, the dosing and timing of exposure to bacterial or fungal contaminants defines whether or not they counteract or exacerbate allergic diseases.…”

Section: Exposure To Microbial Metabolites and Plant Metabolitesmentioning

confidence: 99%

How a farming environment protects from atopy

Deckers

Lambrecht

Hammad

2019

Current Opinion in Immunology

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Identification of fungal candidates for asthma protection in a large population‐based study

Abstract: A large population-based study revealed several fungal taxa with inverse associations with childhood asthma. Molds produce a variety of bioactive compounds with detrimental but also beneficial immunoregulatory capacities, which renders them promising targets for further asthma research.

Cited by 11 publications

References 23 publications

Indoor bacteria and asthma in adults: a multicentre case–control study within ECRHS II

Indoor bacteria and asthma in adults: a multicentre case–control study within ECRHS II

Diversidad Fúngica en La Atmósfera De La Habana (Cuba) Durante Tres Períodos Poco Lluviosos

How a farming environment protects from atopy

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