2019
DOI: 10.1016/j.coi.2019.08.001
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How a farming environment protects from atopy

Abstract: Growing up in farms protect from developing allergies later in life • Farm-induced protection is mediated by a gene-environment interaction • Farm dust components confer protection by acting on both barrier and immune cells

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Cited by 20 publications
(9 citation statements)
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“…Through the biophilia hypothesis, Wilson (1984) argues that humans hold an innate affinity to seek connections with nature. Furthermore, there is evidence to suggest that the environmental microbiome-the diverse consortium of microorganisms in a given environment-can have positive developmental and regulatory influences on the immune system and potentially anxiolytic effects [11][12][13]. This latter claim is supported by a recent mouse study, 2 of 24 in which exposure to trace levels of biodiverse soil dust was significantly associated with reduced anxiety like behaviours [13].…”
Section: Introductionmentioning
confidence: 92%
“…Through the biophilia hypothesis, Wilson (1984) argues that humans hold an innate affinity to seek connections with nature. Furthermore, there is evidence to suggest that the environmental microbiome-the diverse consortium of microorganisms in a given environment-can have positive developmental and regulatory influences on the immune system and potentially anxiolytic effects [11][12][13]. This latter claim is supported by a recent mouse study, 2 of 24 in which exposure to trace levels of biodiverse soil dust was significantly associated with reduced anxiety like behaviours [13].…”
Section: Introductionmentioning
confidence: 92%
“…Many different attempts have been made to prevent allergic diseases, although most of these attempts have been unsuccessful. However, farm animal exposure in early life is a protective factor for allergic diseases in high-income countries 93 and also possibly in some LMICs, although the mechanisms are unclear 94 . In addition, early-life exposure to cats and dogs may prevent the development of allergy but results are not consistent 95 .…”
Section: Preventionmentioning
confidence: 99%
“…Living in an agricultural environment and contacts with farm animals and pets at home has been associated with a higher microbial diversity indoors and a decreased risk of allergic diseases (5)(6)(7)(8). Although the mechanisms of this phenomenon are not fully understood, several lines of evidence suggest that exposure to environmental microbial diversity and direct soil contacts may play a role (9)(10)(11).…”
mentioning
confidence: 99%