Identification of flavouring substances of genotoxic concern present in e-cigarette refills

Barhdadi, Sophia; Mertens, Birgit; Bossuyt, Melissa Van; Anthonissen, Roel; Canfyn, Michaël; Courselle, P.; Rogiers, Vera; Deconinck, Éric; Vanhaecke, Tamara

doi:10.1016/j.fct.2020.111864

Cited by 18 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23,24 Furthermore, diacetyl and 2,3-pentanedione have been observed to induce chromosomal damages. 25 Other commonly used avorings display similar cytotoxicity. According to a safety classication in the literature, 6,26 half of the top ten most frequently added avorings, including vanillin, maltol, ethyl vanillin, benzyl alcohol, and benzaldehyde, have been classied as harmful chemicals.…”

Section: Introductionmentioning

confidence: 99%

Indoor partitioning and potential thirdhand exposure to carbonyl flavoring agents added in e-cigarettes and hookah tobacco

Kim

Vethanayagam

et al. 2022

Environ. Sci.: Processes Impacts

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Indoor partitioning and potential thirdhand exposure to carbonyl flavoring agents added in e-cigarettes and hookah tobacco

Kim

Vethanayagam

et al. 2022

Environ. Sci.: Processes Impacts

View full text Add to dashboard Cite

show abstract

“…It has also been showed that aerosols produced during the heating of e-liquids contain reactive oxygen species (ROS) and can produce oxidative stress through the presence of free radicals, NO [36,37] and carbonyls [38]. It can be suggested that falvoring chemicals and nicotine play an important role in the production of ROS [39][40][41], and the amount and proportions vary from product to product [42]. Nevertheless, the studies also showed that the levels of free radicals are lower in e-fluid and the gas phase of aerosol and heat-not-burn products compared to traditional cigarettes, and contain fewer toxic substances at lower concentrations [43].…”

Section: Chemical Components and Toxins Of E-cigarette Aerosolmentioning

confidence: 99%

The Effects of E-Cigarette Aerosol on Oral Cavity Cells and Tissues: A Narrative Review

Szumilas

Wilk

Szumilas

et al. 2022

Toxics

View full text Add to dashboard Cite

A wealth of research has comprehensively documented the harmful effects of traditional cigarette smoking and nicotine on human health. The lower rate of exposure to harmful chemicals and toxic substances offered by alternative electronic smoking devices (e-cigarettes, vaping, etc.) has made these methods of smoking popular, especially among adolescents and young adults, and they are regarded frequently as safer than regular cigarettes. During vaporization of these so-called e-liquids, toxins, carcinogens and various other chemical substances may be released and inhaled by the user. Data on the potential human health effect attendant on exposure to e-vapor are based mainly on animal and in vitro studies. The oral tissues are the first locus of direct interaction with the components of the inhaled vapor. However, the short-term as well as long-term effects of the exposure are not known. The aim of the review is to briefly present data on the effects of the chemical components and toxins of e-cigarette vapor on oral cavity cells and tissues of oral health.

show abstract

“…Systemically, ECA exposure led to genotoxic effects in rat blood and urine; single and double stranded DNA breaks were observed in peripheral blood leukocytes while base pair substitutions and frame shift mutations were detected in S. typhimurium bacteria incubated with rat urine from exposed animals using the Ames test. Interestingly, the Ames test utilizing ECA condensate in vitro has been shown to be mutagenic [123,124], suggesting that ECA may cause DNA damage and mutagenesis both directly and indirectly as the result of increased oxidative stress and by reducing DNA repair activity in pulmonary and cardiovascular tissues [25].…”

Section: Cancer and Ec Usementioning

confidence: 99%

E-Cigarette Use: Device Market, Study Design, and Emerging Evidence of Biological Consequences

Snoderly

Nurkiewicz

Bowdridge

et al. 2021

IJMS

View full text Add to dashboard Cite

Electronic cigarettes are frequently viewed as a safer alternative to conventional cigarettes; however, evidence to support this perspective has not materialized. Indeed, the current literature reports that electronic cigarette use is associated with both acute lung injury and subclinical dysfunction to the lung and vasculature that may result in pathology following chronic use. E-cigarettes can alter vascular dynamics, polarize innate immune populations towards a proinflammatory state, compromise barrier function in the pulmonary endothelium and epithelium, and promote pre-oncogenic phenomena. This review will summarize the variety of e-cigarette products available to users, discuss current challenges in e-cigarette study design, outline the range of pathologies occurring in cases of e-cigarette associated acute lung injury, highlight disease supporting tissue- and cellular-level changes resulting from e-cigarette exposure, and briefly examine how these changes may promote tumorigenesis. Continued research of the mechanisms by which e-cigarettes induce pathology benefit users and clinicians by resulting in increased regulation of vaping devices, informing treatments for emerging diseases e-cigarettes produce, and increasing public awareness to reduce e-cigarette use and the onset of preventable disease.

show abstract

Identification of flavouring substances of genotoxic concern present in e-cigarette refills

Cited by 18 publications

References 22 publications

Indoor partitioning and potential thirdhand exposure to carbonyl flavoring agents added in e-cigarettes and hookah tobacco

Indoor partitioning and potential thirdhand exposure to carbonyl flavoring agents added in e-cigarettes and hookah tobacco

The Effects of E-Cigarette Aerosol on Oral Cavity Cells and Tissues: A Narrative Review

E-Cigarette Use: Device Market, Study Design, and Emerging Evidence of Biological Consequences

Contact Info

Product

Resources

About