Identification of DNA sequences that imply a novel gammaherpesvirus in seals

Bodewes, Rogier; Contreras, Guillermo J. Sánchez; García, Ana Rubio; Hapsari, Rebriarina; Bildt, Marco W. G. van de; Kuiken, Thijs; Osterhaus, Albert D. M. E.

doi:10.1099/vir.0.000029

Cited by 30 publications

(25 citation statements)

References 32 publications

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“…In contrast, all toothed whale gammaherpesviruses associated with pathological changes were detected in skin and mucosal lesions [10,12,15,[17][18][19][20]. Similarly, several gammaherpesviruses described in seals have also been associated with skin and mucosal ulcerations (summarized in reference [6]). Further research is warranted to determine whether these marine mammal gammaherpesviruses primarily cause the observed skin and mucosal lesions or whether these lesions are secondary to a lymphoproliferative disorder, which is commonly observed in most other gammaherpesvirus infections.…”

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confidence: 91%

“…To date, a total of seven herpesviruses have been described for phocids: one alphaherpesvirus and six gammaherpesviruses [6]. The first detection of a herpesvirus in cetaceans dates back to the late 1980s, when herpesvirus-like particles were observed by electron microscopy (EM) in skin lesions in beluga whales (Delphinapterus leucas) in Canada [7,8] and in the brain of a harbour porpoise (Phocoena phocoena) stranded in Sweden in 1988 [9].…”

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Identification of a novel gammaherpesvirus associated with (muco)cutaneous lesions in harbour porpoises (Phocoena phocoena)

et al. 2015

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Herpesviruses infect a wide range of vertebrates, including toothed whales of the order Cetacea. One of the smallest toothed whales is the harbour porpoise (Phocoena phocoena), which is widespread in the coastal waters of the northern hemisphere, including the North Sea. Here, we describe the detection and phylogenetic analysis of a novel gammaherpesvirus associated with mucocutaneous and skin lesions in stranded harbour porpoises along the Dutch coast, tentatively designated phocoenid herpesvirus 1 (PhoHV1). Phylogenetically, PhoHV1 forms a monophyletic clade with all other gammaherpesviruses described in toothed whales (Odontoceti) to date, suggesting a common evolutionary origin.

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Identification of a novel gammaherpesvirus associated with (muco)cutaneous lesions in harbour porpoises (Phocoena phocoena)

et al. 2015

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“…The ORF1, the largest ORF, does not display any significant nucleotide identity to any virus sequence using BLASTn in GenBank, but shares low identity with a seal anellovirus (GenBank no. : KM262782) (30.2 % identity) [15] and a pine marten torque teno virus (GenBank no. : JN704611) (29.4 % identity) [16] based on the amino acid sequence of ORF1.…”

Section: Resultsmentioning

confidence: 99%

Identification and genomic characterization of a novel species of feline anellovirus

Zhang

Wang

et al. 2016

Virol J

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Here, a novel feline anellovirus strain (named FelineAV621 and GenBank no. KX262893) was detected in two cats with diarrhea. The complete genome of FelineAV621 is 2409 nt long with a G+C content of 56.67 %, including three open reading frames (ORFs). Phylogenetic analysis based on the amino acid sequence of the putative capsid protein (ORF1) indicated that FelineAV621 belonged to a novel anellovirus species inside a clade containing the seal anellovirus, canine TTVs, and porcine TTVs, but was distant from all the previous feline anelloviruses.

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“…Ng et al (2009a) used tumors to identify STTV1 as the causative agent of fibropappillomas in Florida green sea turtles. Bodewes et al (2015) identified Phocine herpesvirus 7 (PhHV-7) as the etiological agent of ulcerative gingivitis in phocines (Bodewes et al, 2015) while Enhydralutis papilloma virus 1 (EIPV-1) was shown to be the etiological agent of oral tumors diagnosed in Southern otters ( Enhydra lutris Nereis) (Ng et al, 2015). …”

Section: Diagnostic Role Of Viral Metagenomics In Clinical Tissuesmentioning

confidence: 99%

Current Advances on Virus Discovery and Diagnostic Role of Viral Metagenomics in Aquatic Organisms

et al. 2017

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The global expansion of the aquaculture industry has brought with it a corresponding increase of novel viruses infecting different aquatic organisms. These emerging viral pathogens have proved to be a challenge to the use of traditional cell-cultures and immunoassays for identification of new viruses especially in situations where the novel viruses are unculturable and no antibodies exist for their identification. Viral metagenomics has the potential to identify novel viruses without prior knowledge of their genomic sequence data and may provide a solution for the study of unculturable viruses. This review provides a synopsis on the contribution of viral metagenomics to the discovery of viruses infecting different aquatic organisms as well as its potential role in viral diagnostics. High throughput Next Generation sequencing (NGS) and library construction used in metagenomic projects have simplified the task of generating complete viral genomes unlike the challenge faced in traditional methods that use multiple primers targeted at different segments and VPs to generate the entire genome of a novel virus. In terms of diagnostics, studies carried out this far show that viral metagenomics has the potential to serve as a multifaceted tool able to study and identify etiological agents of single infections, co-infections, tissue tropism, profiling viral infections of different aquatic organisms, epidemiological monitoring of disease prevalence, evolutionary phylogenetic analyses, and the study of genomic diversity in quasispecies viruses. With sequencing technologies and bioinformatics analytical tools becoming cheaper and easier, we anticipate that metagenomics will soon become a routine tool for the discovery, study, and identification of novel pathogens including viruses to enable timely disease control for emerging diseases in aquaculture.

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Identification of DNA sequences that imply a novel gammaherpesvirus in seals

Cited by 30 publications

References 32 publications

Identification of a novel gammaherpesvirus associated with (muco)cutaneous lesions in harbour porpoises (Phocoena phocoena)

Identification of a novel gammaherpesvirus associated with (muco)cutaneous lesions in harbour porpoises (Phocoena phocoena)

Identification and genomic characterization of a novel species of feline anellovirus

Current Advances on Virus Discovery and Diagnostic Role of Viral Metagenomics in Aquatic Organisms

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