Identification of Differentially Expressed Genes Reveals BGN Predicting Overall Survival and Tumor Immune Infiltration of Gastric Cancer

Abstract

Gastric cancer (GC) is one of the most widely occurring malignancies worldwide. Although the diagnosis and treatment strategies of GC have been greatly improved in the past few decades, the morbidity and lethality rates of GC are still rising due to lacking early diagnosis strategies and powerful treatments. In this study, a total of 37 differentially expressed genes were identified in GC by analyzing TCGA, GSE118897, GSE19826, and GSE54129. Using the PPI database, we identified 17 hub genes in GC. By analyzing the expression of hub genes and OS, MFAP2, BGN, and TREM1 were related to the prognosis of GC. In addition, our results showed that higher levels of BGN exhibited a significant correlation with shorter OS time in GC. Nomogram analysis showed that the dysregulation of BGN could predict the prognosis of GC. Moreover, we revealed that BGN had a markedly negative correlation with B cells but had positive correlations with CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in GC samples. The pan-cancer analysis demonstrated that BGN was differentially expressed and related to tumor-infiltrating immune cells across human cancers. This study for the first time comprehensively revealed that BGN was a potential biomarker for the prediction of GC prognosis and tumor immune infiltration.

Identification of secretory factors associated with suppressive tumor microenvironment in esophageal cancer

“…Recently, aberrant expression of MFAP2 has been reported in several cancer types: stomach adenocarcinoma, gastric cancer, colon adenocarcinoma and hepatocellular carcinoma. Most of these researches focused on its upregulation in tumor tissues and their association with poor prognosis [31][32][33][34]. Here, we established the connection between MFAP2 gene upregulation and poor prognosis via suppressive tumor microenvironment.…”

Identification of Key Genes as Potential Drug Targets for Gastric Cancer

“…For example, overexpression of TIMP1 promoted GC cell proliferation [50] . BGN was identified as a candidate biomarker for GC prognosis and tumor immune infiltration [51] . Overexpression of SPP1 was closely correlated with GC occurrence [52] .…”

The Dysregulation of SOX Family Correlates with DNA Methylation and Immune Microenvironment Characteristics to Predict Prognosis in Hepatocellular Carcinoma

“…The co-expression molecules of SOX2 and SOX10 were really small, so the roles of these three SOX family molecules in HCC may need to be explored separately. In addition, the top 10 hub genes POSTN, BGN, MMP2, THBS2, CD34, ESR1, VEGFC, AEBP1, CLDN5, and LOXL1 seem to be related with cancer stemness (such as cancer-associated fibroblasts [ 55 ], EMT process [ 56 ], tumor immune infiltration [ 57 ], and metastasis [ 58 ]). In conclusion, the function of SOX family on HCC may link with these cancer stemness-related proteins, and these proteins may have a potential to be biomarkers or therapeutic targets.…”