Identification of dairy fractions with anti-inflammatory properties in models of acute gout

Abstract

Both protein and lipid fractions within dairy products are capable of modulating the inflammatory response to MSU crystals.

Buffalo (Bubalus bubilis) colostrum and milk fat globule membrane fractions are potent antioxidants

“…An in depth knowledge functional properties of milk compounds is a prerequisite in the design of such foods. Further development of economically viable industrial processes in the production of bioactive milk components is critical challenge to the food technologists [21,23,24]. The results obtained in the present study showcases the superior beneficial health effects of the CFGM over the MFGM.…”

“…The FABP shows immunostimulating, opioid and antioxidant peptides. Because of MFGM's phospholipid enrichment and unique biochemical nature, we hypothesized that diets which include MFGM as a fat source might offer better protection against an exaggerated inflammatory response [23,24,25]. Compared to MFGM very little literature is available on colostrum fat globule membranes (CFGM).…”

Tryptophan-containing milk protein-derived dipeptides inhibit xanthine oxidase

“…Milk and dairy products have also been associated with the prevention of gout in humans as they can reduce serum urate [10,11,17]. Various fractions of milk have been tested in a cell culture model of THP-1 cells for their anti-inflammatory properties [16]. Glycomacropeptide was shown to inhibit Interleukin 1gene and protein expression of THP-1 cells and a milk fat extract (G600) could reduce the production of IL8 in response to monosodium urate monohydrate crystals [16].…”

“…Various fractions of milk have been tested in a cell culture model of THP-1 cells for their anti-inflammatory properties [16]. Glycomacropeptide was shown to inhibit Interleukin 1gene and protein expression of THP-1 cells and a milk fat extract (G600) could reduce the production of IL8 in response to monosodium urate monohydrate crystals [16]. These in vitro findings were confirmed in an in vivo mice model of gout where feeding with GMP and G600 resulted in an anti-inflammatory effect [16].…”

“…Glycomacropeptide was shown to inhibit Interleukin 1gene and protein expression of THP-1 cells and a milk fat extract (G600) could reduce the production of IL8 in response to monosodium urate monohydrate crystals [16]. These in vitro findings were confirmed in an in vivo mice model of gout where feeding with GMP and G600 resulted in an anti-inflammatory effect [16]. Recently, Dalbeth et al [15] showed that ingestion of skim milk powder enriched with G600 and GMP could reduce the frequency of gout flares with patients.…”