Identification of cross-reactive and genuine Parietaria judaica pollen allergens

Stumvoll, S.; Westritschnig, Kerstin; Lidholm, Jonas; Spitzauer, Susanne; Colombo, Piergiuseppe; Duro, Giovanni; Kraft, Dietrich; Geraci, Domenico; Valenta, Rudolf

doi:10.1067/mai.2003.1376

Cited by 60 publications

(58 citation statements)

References 29 publications

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“…judaica es una de las fuentes más importante de polen alérgeno en la zona Mediterránea (Stumvoll et al, 2003;Fotiu et al, 2011). La mayoría de trabajos existentes sobre esta especie han sido llevados a cabo para caracterizar los alérge-nos presentes en su polen (Ford et al, 1986;Costa et al, 1994;Duro et al, 1996;Stumvoll et al, 2003), además de estudiar distintos factores que condicionan la concentración del mismo en el ambiente (Fornaciari et al, 1992;Galán et al, 2000;Fotiu et al, 2011).…”

Section: Parietaria Judaica Lunclassified

Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

Sancho¹,

Mercedes²

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Section: Parietaria Judaica Lunclassified

Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

Sancho¹,

Mercedes²

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“…In this context, the major allergen of Parietaria , rPar j 2, has been shown to represent a marker for a genuine sensitization to Parietaria pollen. Par j 2 is a major allergenic component of Parietaria pollen but absent from other weeds (e.g., ragweed, mugwort) [149]. Likewise, the major house dust mite allergens, Der p 1 and Der p 2, may be used as marker allergens to confirm genuine sensitization to house dust mites [150].…”

Section: Major Source-specific Marker Allergens To Determine the Dismentioning

confidence: 99%

Transition from a Botanical to a Molecular Classification in Tree Pollen Allergy: Implications for Diagnosis and Therapy

Mothes¹,

Horak

Valenta³

2004

Int Arch Allergy Immunol

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Tree pollens are among the most important allergen sources. Allergic cross-reactivity to pollens of trees from various plant orders has so far been classified according to botanical relationships. In this context, cross-reactivities to pollens of trees of the Fagales order (birch, alder, hazel, hornbeam, oak, chestnut), fruits and vegetables, between pollens of the Scrophulariales (olive, ash, plantain, privet, lilac) and pollens of the Coniferales (cedar, cypress, pine) are well established. The application of molecular biology methods for allergen characterization has revealed the molecular nature of many important tree pollen allergens. We review the spectrum of tree pollen allergens and propose a classification of tree pollen and related allergies based on major allergen molecules instead of botanical relationships among the allergenic sources. This molecular classification suggests the major birch pollen allergen, Bet v 1 as a marker for Fagales pollen and related plant food allergies, the major olive pollen allergen, Ole e 1, as a possible marker for Scrophulariales pollen allergy and the cedar allergens, Cry j 1 and Cry j 2, as potential markers for allergy to Coniferales pollens. We exemplify for Fagales pollen allergy and Bet v 1 that major marker allergens are diagnostic tools to determine the disease-eliciting allergen source. Information obtained by diagnostic testing with marker allergens will be important for the appropriate selection of patients for allergen-specific forms of therapy.

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“…Parietaria judaica is a very important pollen allergen from the Mediterranean region of Europe. It has been reported that up to 80% of the pollinosis patients from the Mediterranean regions are sensitized to Parietaria allergens [4]. The different species of Parietaria are known to cross-react among themselves [5], but cross-reactivity of Parietaria with other members of the Urticaceae, such as Urtica dioica and Boehmeria nivea, is observed to be poor [6, 7, 8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cross-Reactivity between <i>Holoptelea integrifolia</i> and <i>Parietaria judaica</i>

Sharma

Panzani²,

Gaur³

et al. 2005

Int Arch Allergy Immunol

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Background:Holoptelea integrifolia and Parietaria judaica belong to the family Urticaceae, but are geographically distantly located. H. integrifolia is an important pollen allergen of India and sensitizes almost 10% of the atopic population in Delhi. P. judaica, on the other hand, is a very dominant pollen allergen of the Mediterranean region, sensitizing almost 80% of the allergic population. Since both these important pollen allergens belong to the family Urticaceae, the objective of the present study was to assess cross-reactivity between these two pollen allergens from different geographical regions. Methods: Cross-reactivity between these two pollen allergens was assessed on the basis of skin prick tests and ELISA, ELISA inhibition and immunoblot inhibition studies. Results: Out of 44 atopic Indian patients skin prick tested with H. integrifolia extract, 34% were found to be sensitized. All the patients sensitized to H. integrifolia also showed varying degrees of skin positivity to P. judaica pollen extract. ELISA and ELISA inhibition studies suggested strong cross-reactivity between H. integrifolia and P. judaica pollen. Immunoblot inhibition studies revealed that 14-, 16-, 28-, 38-, 42- and 46-kDa proteins are the cross-reactive proteins in H. integrifolia and P. judaica. However, Par j 1, the major allergen of P. judaica, is absent in H. integrifolia pollen. Conclusion:H. integrifolia and P. judaica pollens share cross-reactive as well as unique epitopes. The major allergen of P. judaica, Par j 1, seems to be absent in H. integrifolia pollen allergen.

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Identification of cross-reactive and genuine Parietaria judaica pollen allergens

Cited by 60 publications

References 29 publications

Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

Transition from a Botanical to a Molecular Classification in Tree Pollen Allergy: Implications for Diagnosis and Therapy

Evaluation of Cross-Reactivity between <i>Holoptelea integrifolia</i> and <i>Parietaria judaica</i>

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