Identification of Chromosome Aberrations among Benign Prostatic Hyperplasia Patients in Tamilnadu, Southern India

Balachandar, V.; Kumar, B.V. Manoj; Devi, Subramaniam Mohana; Sangeetha, R.; Pappuswamy, Manikantan; Kumar, Satish; Sudha, S.; Sasikala, K.; Dharwatgar, S.N.

doi:10.1080/09723757.2010.11886099

Cited by 2 publications

(6 citation statements)

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“…The authors concluded that Y loss could also be considered suggestive of a possible progression from BPH with Y loss to adenocarcinoma [ 6 ]. Balachandar et al [ 4 ] investigated chromosomal aberrations in peripheral blood lymphocyte cultures from patients clinically presumed to have BPH and reported 13 chromosomal aberrations (chromosomes 1, 6, 8, 13, 16, and 18) in 27 patients. No Y loss was detected in that study [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Balachandar et al [ 4 ] investigated chromosomal aberrations in peripheral blood lymphocyte cultures from patients clinically presumed to have BPH and reported 13 chromosomal aberrations (chromosomes 1, 6, 8, 13, 16, and 18) in 27 patients. No Y loss was detected in that study [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another study included prostatic tissues of patients with a diagnosis of bladder cancer [ 5 ]. In Balachandar et al's [ 4 ] study, only PSA levels were accepted as a criterion for the diagnosis of BPH. The presence of BPH was not confirmed by any pathologic specimens.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have been conducted on chromosomal abnormalities and gene polymorphisms in patients with BPH [ 4 5 6 7 ]. As a result, very little is known about cytogenetic changes in these patients.…”

Section: Introductionmentioning

confidence: 99%

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Chromosomal aberrations in benign prostatic hyperplasia patients

et al. 2016

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PurposeTo investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH).Materials and MethodsA total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address their primary urological problem. All patients were evaluated by use of a comprehensive medical history and rectal digital examination. The preoperative evaluation also included serum prostate-specific antigen (PSA) measurement and ultrasonographic measurement of prostate volume. Prostate cancer was detected in one patient, who was then excluded from the study. We performed conventional cytogenetic analyses of short-term cultures of 53 peripheral blood samples obtained from the BPH patients.ResultsThe mean (±standard deviation) age of the 53 patients was 67.8±9.4 years. The mean PSA value of the patients was 5.8±7.0 ng/mL. The mean prostate volume was 53.6±22.9 mL. Chromosomal abnormalities were noted in 5 of the 53 cases (9.4%). Loss of the Y chromosome was the most frequent chromosomal abnormality and was observed in three patients (5.7%). There was no statistically significant relationship among age, PSA, prostate volume, and chromosomal changes.ConclusionsLoss of the Y chromosome was the main chromosomal abnormality found in our study. However, this coexistence did not reach a significant level. Our study concluded that loss of the Y chromosome cannot be considered relevant for the diagnosis of BPH as it is for prostate cancer. Because BPH usually occurs in aging men, loss of the Y chromosome in BPH patients may instead be related to the aging process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chromosomal aberrations in benign prostatic hyperplasia patients

et al. 2016

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show abstract

“…Few studies have been conducted on chromosomal abnormalities and gene polymorphisms in patients with BPH [ 8 ], [ 9 ], [ 10 ], [ 11 ], therefore information regarding cytogenetic changes in these patients is scarce.…”

Section: Introductionmentioning

confidence: 99%