Chromosomal aberrations in benign prostatic hyperplasia patients

Abstract

PurposeTo investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH).Materials and MethodsA total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address their primary urological problem. All patients were evaluated by use of a comprehensive medical history and rectal digital examination. The preoperative evaluation also included serum prostate-specific antigen (PSA) measurement and ultrasonographic measurement of prostate volume. Prostate cancer was detected in one patient, who was then excluded from the study. We performed conventional cytogenetic analyses of short-term cultures of 53 peripheral blood samples obtained from the BPH patients.ResultsThe mean (±standard deviation) age of the 53 patients was 67.8±9.4 years. The mean PSA value of the patients was 5.8±7.0 ng/mL. The mean prostate volume was 53.6±22.9 mL. Chromosomal abnormalities were noted in 5 of the 53 cases (9.4%). Loss of the Y chromosome was the most frequent chromosomal abnormality and was observed in three patients (5.7%). There was no statistically significant relationship among age, PSA, prostate volume, and chromosomal changes.ConclusionsLoss of the Y chromosome was the main chromosomal abnormality found in our study. However, this coexistence did not reach a significant level. Our study concluded that loss of the Y chromosome cannot be considered relevant for the diagnosis of BPH as it is for prostate cancer. Because BPH usually occurs in aging men, loss of the Y chromosome in BPH patients may instead be related to the aging process.

Genetic alterations in benign prostatic hyperplasia patients

“…In 2010, Balachandar et al [ 8 ] reported major chromosomal aberrations like deletion, translocation, inversion in chromosomes 1, 6, 8, 13, 16, 18 in blood samples of BPH patients. Recently, Altok et al [ 17 ] demonstrated that chromosomal abnormalities were noted in 5 of the 53 cases (9.4%). Loss of the Y chromosome was the most frequent chromosomal abnormality and was observed in three patients (5.7%).…”

Benign Prostatic Hyperplasia (BPH): A Comprehensive Analysis of the Malaise and Summarizing Possible Management Options through Phytotherapeutic Agents

“…In the prostate gland, the process of aging encompasses cellular mitogenesis and hormonal homeostasis variations, which then lead to chromosomal aberration and death. 18 In addition to this, the aging process is also linked to various inflammatory conditions and microvascular illnesses. All these processes trigger the occurrence of ischemia and oxidative stress, making BPH more likely.…”

Pathophysiology of benign prostate enlargement and lower urinary tract symptoms: Current concepts

“…Age itself is the major risk factor for BPE/BPH and LUTS. The aging process involves changes in cellular mitogenesis and hormonal homeostasis in the prostate gland, which later proceed to chromosomal aberration and apoptosis [ 21 ]. Aging is also associated with inflammation and microvascular disease, which provoke ischemia and oxidative stress, providing a favorable environment for BPH [ 22 ].…”