Identification of cardiac-related circulating microRNA profile in human chronic heart failure

Li, Huaping; Fan, Jiahui; Yin, Zongsheng; Wang, Feng; Chen, Chen; Wang, Dao Wen

doi:10.18632/oncotarget.6631

Cited by 76 publications

(53 citation statements)

References 30 publications

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“…For example, miR-660-5p was revealed to be downregulated in thyroid tissues of patients with Graves' disease, which suggested a potential involvement of miR-660-5p in the pathogenesis of this disease (36). Aberrant expression of miR-660-5p, as detected by RT-qPCR, demonstrated a relationship with the prediction or diagnosis of myocardial infarction or chronic heart failure (37,38).…”

Section: Discussionmentioning

confidence: 98%

miR‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma

Chen

Jin

et al. 2017

Mol Med Report

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Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system with poor prognosis. microRNAs (miRNAs) are a class of small, non‑coding RNA molecules that serve important roles in biological and pathological processes in several types of human tumors. miRNA (miR)‑660‑5p is dysregulated in many human cancers; however, its role in renal cell carcinoma is currently unclear. In the present study, reverse transcription‑quantitative polymerase chain reaction was performed to examine the expression levels of miR‑660‑5p in RCC tissues and paired normal adjacent tissues (NATs). To determine the function of miR‑660‑5p in RCC cells, wound‑healing and Matrigel assays were performed to determine the effects of miR‑660‑5p on cell migration and invasion, respectively. MTT and Cell Counting kit‑8 assays were performed to determine the effects of miR‑660‑5p on RCC cell proliferation. In addition, flow cytometric analysis was performed to validate the effects of miR‑660‑5p on apoptosis. The results indicated that miR‑660‑5p expression was downregulated in RCC tissues compared with NATs. Restoration of miR‑660‑5p expression using synthetic mimics may suppress cell migration, invasion and proliferation, and induce cell apoptosis, while using synthetic inhibitors may promote cell migration, invasion and proliferation, and suppress cell apoptosis. These results suggested that miR‑660‑5p may serve a tumor suppressive role in RCC tumorigenesis.

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Section: Discussionmentioning

confidence: 98%

miR‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma

Chen

Jin

et al. 2017

Mol Med Report

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“…Recent study identified that three cardiac fibroblast-derived miRNAs (miR-660-3p, miR-665, and miR-1285-3p) were found obviously elevated in heart and plasma during CHF and significantly correlated with left ventricular ejection fraction (LVEF), holding promise as potential diagnostic biomarker for CHF. These three circulating miRNAs may be used as potential biomarkers for diagnosis of CHF patients [ 67 ].…”

Section: Circulating Mirnas As a Potential Biomarker For Hf Patienmentioning

confidence: 99%

Diagnostic, Prognostic, and Therapeutic Value of Circulating miRNAs in Heart Failure Patients Associated with Oxidative Stress

Sheikh

Salma

Zhang

et al. 2016

Oxidative Medicine and Cellular Longevity

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Heart failure is a major public health problem especially in the aging population (≥65 years old), affecting nearly 5 million Americans and 15 million European people. Effective management of heart failure (HF) depends on a correct and rapid diagnosis. Presently, BNP (brain natriuretic peptide) or N-terminal pro-brain natriuretic peptide (NT-proBNP) assay is generally accepted by the international community for diagnostic evaluation and risk stratification of patients with HF. However, regardless of its widespread clinical use, BNP is still encumbered by reduced specificity. As a result, diagnosis of heart failure remains challenging. Although significant improvement happened in the clinical management of HF over the last 2 decades, traditional treatments are ultimately ineffective in many patients who progress to advanced HF. Therefore, a novel diagnostic, prognostic biomarker and new therapeutic approach are required for clinical management of HF patients. Circulating miRNAs seem to be the right choice for novel noninvasive biomarkers as well as new treatment strategies for HF. In this review, we briefly discuss the diagnostic, prognostic, and therapeutic role of circulating miRNAs in heart failure patients. We also mentioned our own technique of extraction of RNA and detection of circulating miRNAs from human plasma and oxidative stress associated miRNAs with HF.

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“…DJ-1 was also shown to protect the heart from ischemiareperfusion injury [142,143]. Moreover, the work of Li et al shows that miR-4639 is almost 3-fold overexpressed in chronic heart failure patients compared to the control group [144]. All this leads us to the following hypothesis (see Figure 3): "overexpression of miR-4639 in the heart downregulates DJ-1 that protects the heart from oxidative damage, which may be one of the causes leading to heart failure.…”

Section: Example 2: Hypotheses and Potentially New Insightsmentioning

confidence: 99%

Literature-Based Enrichment Insights into Redox Control of Vascular Biology

Essack

Salhi

Stanimirović

et al. 2019

Oxidative Medicine and Cellular Longevity

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In cellular physiology and signaling, reactive oxygen species (ROS) play one of the most critical roles. ROS overproduction leads to cellular oxidative stress. This may lead to an irrecoverable imbalance of redox (oxidation-reduction reaction) function that deregulates redox homeostasis, which itself could lead to several diseases including neurodegenerative disease, cardiovascular disease, and cancers. In this study, we focus on the redox effects related to vascular systems in mammals. To support research in this domain, we developed an online knowledge base, DES-RedoxVasc, which enables exploration of information contained in the biomedical scientific literature. The DES-RedoxVasc system analyzed 233399 documents consisting of PubMed abstracts and PubMed Central full-text articles related to different aspects of redox biology in vascular systems. It allows researchers to explore enriched concepts from 28 curated thematic dictionaries, as well as literature-derived potential associations of pairs of such enriched concepts, where associations themselves are statistically enriched. For example, the system allows exploration of associations of pathways, diseases, mutations, genes/proteins, miRNAs, long ncRNAs, toxins, drugs, biological processes, molecular functions, etc. that allow for insights about different aspects of redox effects and control of processes related to the vascular system. Moreover, we deliver case studies about some existing or possibly novel knowledge regarding redox of vascular biology demonstrating the usefulness of DES-RedoxVasc. DES-RedoxVasc is the first compiled knowledge base using text mining for the exploration of this topic.

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Identification of cardiac-related circulating microRNA profile in human chronic heart failure

Cited by 76 publications

References 30 publications

miR‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma

miR‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma

Diagnostic, Prognostic, and Therapeutic Value of Circulating miRNAs in Heart Failure Patients Associated with Oxidative Stress

Literature-Based Enrichment Insights into Redox Control of Vascular Biology

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