Identification of Bioactive Compounds of the Endophytic Fungus &lt;i&gt;Aspergillus egypticus&lt;/i&gt;-HT166S Inhibiting the Activity of Pancreatic α-Amylase

Ruzieva, D. M.; Gulyamova, Tashkan; Nasmetova, Saodat; Mukhammedov, Iqbol; Rasulova, Gulchehra

doi:10.4274/tjps.galenos.2021.05873

Cited by 4 publications

(4 citation statements)

References 36 publications

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“…Fungal endophytes derived from medicinal diabetic plants in Uzbekistan exhibited a remarkable 60-82% inhibitory activity against α-amylase. Recently, K-10, a polymethoxylated flavone methanolic extract from endophytic Aspergillus egypticus-HT166S isolated from Helianthus tuberosus showed an inhibition of α-amylase similar to a reference standard (acarbose) in lab conditions [177,178]. Similarly, endophytic isolates from Stemphylium globuliferum PTFL005 and PTFL011 exhibited inhibitory activity against α-glucosidase with IC 50 values of 17.37 and 10.71 µg/mL, respectively.…”

Section: Antidiabetic Compounds From Endophytic Fungimentioning

confidence: 97%

Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

et al. 2023

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The seminal discovery of paclitaxel from endophytic fungus Taxomyces andreanae was a milestone in recognizing the immense potential of endophytic fungi as prolific producers of bioactive secondary metabolites of use in medicine, agriculture, and food industries. Following the discovery of paclitaxel, the research community has intensified efforts to harness endophytic fungi as putative producers of lead molecules with anticancer, anti-inflammatory, antimicrobial, antioxidant, cardio-protective, and immunomodulatory properties. Endophytic fungi have been a valuable source of bioactive compounds over the last three decades. Compounds such as taxol, podophyllotoxin, huperzine, camptothecin, and resveratrol have been effectively isolated and characterized after extraction from endophytic fungi. These findings have expanded the applications of endophytic fungi in medicine and related fields. In the present review, we systematically compile and analyze several important compounds derived from endophytic fungi, encompassing the period from 2011 to 2022. Our systematic approach focuses on elucidating the origins of endophytic fungi, exploring the structural diversity and biological activities exhibited by these compounds, and giving special emphasis to the pharmacological activities and mechanism of action of certain compounds. We highlight the tremendous potential of endophytic fungi as alternate sources of bioactive metabolites, with implications for combating major global diseases. This underscores the significant role that fungi can play in the discovery and development of novel therapeutic agents that address the challenges posed by prevalent diseases worldwide.

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Section: Antidiabetic Compounds From Endophytic Fungimentioning

confidence: 97%

Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

et al. 2023

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“…After the extraction process, the subsequent step involves isolating the bioactive compounds from the complex mixture obtained from endophytic fungi. Chromatographic techniques, including methods such as thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC), play a crucial role in separating this mixture into individual compounds based on their distinct physicochemical properties [38].…”

Section: Extraction and Identification Of Bioactive Compounds From En...mentioning

confidence: 99%

Health-Promoting Effects of Bioactive Compounds from Plant Endophytic Fungi

Wijesekara,

2023

JoF

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The study examines the intricate relationship between plants and the endophytic fungi inhabiting their tissues. These fungi harmoniously coexist with plants, forming a distinct symbiotic connection that has caught scientific attention due to its potential implications for plant health and growth. The diverse range of bioactive compounds produced by these fungi holds significant promise for human health. The review covers various aspects of this topic, starting by introducing endophytic microorganisms, explaining their colonization of different plant parts, and illuminating their potential roles in enhancing plant defense against diseases and promoting growth. The review emphasizes the widespread occurrence and diversity of these microorganisms among plant species while highlighting the complexities and significance of isolating and extracting bioactive compounds from them. It focuses on the health benefits of these bioactive compounds, including their capacity to exhibit antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. The review delves into the mechanisms behind these health-promoting effects, spotlighting how the compounds interact with cellular receptors, signaling pathways, and gene expression. In conclusion, the review provides a comprehensive overview of health-promoting bioactive compounds from plant endophytic fungi. It outlines their multifaceted impact, potential applications, and future research avenues in health and medicine.

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“…They also tested the known compounds rubrolide S and butyrolactone I from A. terreus, which also exhibited stronger α-glucosidase inhibitory activity, with IC 50 values of 1.2 μM and 61.6 μM, respectively (Figure 2). The Aspergillus egypticus HT166S (endophytic fungus) was isolated from the plant Helianthus tuberosus by Ruzieva et al (2020). Methanol extracts were found to possess α-amylase inhibitory activity with 75.4% inhibition rate.…”

Section: Aspergillusmentioning

confidence: 99%

“…The Aspergillus egypticus HT166S (endophytic fungus) was isolated from the plant Helianthus tuberosus by Ruzieva et al (2020) . Methanol extracts were found to possess α-amylase inhibitory activity with 75.4% inhibition rate.…”

Section: Inhibitors Of Glycosidases From Different Microbesmentioning

confidence: 99%

Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review

Wang

Shang²,

Bai³

et al. 2022

Front. Microbiol.

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α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity. Microbes are an important source of constituents that have the potential to inhibit glycosidases and can be used as sources of new drugs and dietary supplements. For example, the α-glucosidase inhibitor acarbose, isolated from Actinoplanes sp., has played an important role in adequately controlling type 2 diabetes, but this class of marketed drugs has many drawbacks, such as poor compliance with treatment and expense. This demonstrates the need for new microorganism-derived resources, as well as novel classes of drugs with better compliance, socioeconomic benefits, and safety. This review introduces the literature on microbial sources of α-glucosidase and α-amylase inhibitors, with a focus on endophytes and marine microorganisms, over the most recent 5 years. This paper also reviews the application of glycosidase inhibitors as drugs and dietary supplements. These studies will contribute to the future development of new microorganism-derived glycosidase inhibitors.

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Identification of Bioactive Compounds of the Endophytic Fungus <i>Aspergillus egypticus</i>-HT166S Inhibiting the Activity of Pancreatic α-Amylase

Cited by 4 publications

References 36 publications

Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

Health-Promoting Effects of Bioactive Compounds from Plant Endophytic Fungi

Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review

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