Identification of Bet v 1‐related allergens in fig and other Moraceae fruits

Hemmer, Wolfgang; Focke, Margarete; Marzban, Gorji; Swoboda, Ines; Jarisch, Reinhart; Laimer, Margit

doi:10.1111/j.1365-2222.2010.03486.x

Cited by 28 publications

(14 citation statements)

References 25 publications

(34 reference statements)

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“…Ficus benjamina , which is a popular indoor plant in private homes and offices, releases allergens into the air. The development of an allergy via inhalation followed by allergic sympt‐oms after consumption of figs is possible . The presence of cross‐reacting structures has been demonstrated .…”

Section: Specific Aspects Of Relevant Inhalant Allergens Leading To Fmentioning

confidence: 99%

Position paper of the EAACI: food allergy due to immunological cross‐reactions with common inhalant allergens

Werfel

Asero

Ballmer‐Weber

et al. 2015

Allergy

200

167

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In older children, adolescents, and adults, a substantial part of all IgE-mediated food allergies is caused by cross-reacting allergenic structures shared by inhalants and foods. IgE stimulated by a cross-reactive inhalant allergen can result in diverse patterns of allergic reactions to various foods. Local, mild, or severe systemic reactions may occur already after the first consumption of a food containing a cross-reactive allergen. In clinical practice, clinically relevant sensitizations are elucidated by skin prick testing or by the determination of specific IgE in vitro. Component-resolved diagnosis may help to reach a diagnosis and may predict the risk of a systemic reaction. Allergy needs to be confirmed in cases of unclear history by oral challenge tests. The therapeutic potential of allergen immunotherapy with inhalant allergens in pollen-related food allergy is not clear, and more placebo-controlled studies are needed. As we are facing an increasing incidence of pollen allergies, a shift in sensitization patterns and changes in nutritional habits, and the occurrence of new, so far unknown allergies due to cross-reactions are expected.Food as a trigger for allergic reactions is gaining more importance, and up to 60% of food allergies in older children, adolescents, and adults are linked with an inhalant allergy. In contrast to classical food allergies where primary sensitization is thought to occur in the gastrointestinal tract and is directed mostly against stable food allergens, primary sensitization in pollen-related and some other cross-reactive food allergies is considered to be against aeroallergens.Although epidemiologic data are scarce, there is no doubt that the increase in pollen allergies is going to be followed by an increase in the so-called pollen-related food allergies (1-4).Cross-reaction is based on the binding of an IgE antibody to homologous allergen structures-shared linear or-in most cases-conformational epitopes (i.e., structural similarities). Such structures may be conserved among proteins with

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Section: Specific Aspects Of Relevant Inhalant Allergens Leading To Fmentioning

confidence: 99%

Position paper of the EAACI: food allergy due to immunological cross‐reactions with common inhalant allergens

Werfel

Asero

Ballmer‐Weber

et al. 2015

Allergy

200

167

View full text Add to dashboard Cite

show abstract

“…The bands recognized by the patient and by the antierCyp c 1 antiserum in immunoblot experiments (eFig 3) were excised from Coomassiestained sodium dodecyl sulfateepolyacrylamide gel electrophoresis gels (eFig 3), subjected to tryptic digest and analyzed by liquid chromatographyeelectrospray ionizationetandem mass spectrometry. 3 Cross-referencing the generated peak list against the National Center for Biotechnology Information protein databank revealed that the bands recognized by the patient were indeed parvalbumins (eTable 2), probably a-parvalbumins, because in all 3 species peptides with the highest sequence homology to parvalbumin 7 from channel fish, a parvalbumin belonging to the aparvalbumin group, were identified. Therefore, we can conclude that this patient is sensitized to parvalbumins.…”

mentioning

confidence: 99%

Unusual sensitization to parvalbumins from certain fish species

Raith

Klug

Sesztak‐Greinecker³

et al. 2014

Annals of Allergy, Asthma & Immunology

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“…Therefore, all they can induce birch pollen-related oral allergy syndrome 12. Hemmer et al identified PR 10 allergens in Moraceae fruits including mulberry fruit, which cross-reacted with Bet v 1 13. Therefore, sensitization to PR 10 proteins can be a cause for the development of pollen-food syndrome 7.…”

Section: Discussionmentioning

confidence: 99%

An IgE-Mediated Allergic Reaction Caused by Mulberry Fruit

Choi

Sim

et al. 2015

Allergy Asthma Immunol Res

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Mulberry (Morus spp.) is a widespread deciduous tree and its fruit is commonly eaten in Korea and eastern Asia. Some reports demonstrate that mulberry fruit is a food allergen in the Mediterranean area. However, there has been no report of systemic allergic reactions after ingesting mulberry fruit in Korea. An 18-year-old boy with a mulberry fruit allergy visited our allergy clinic. He had experienced generalized urticaria, chest tightness, breathing difficulty, and abdominal cramping after ingesting mulberry fruit. The patient had a positive skin reaction to mulberry fruit extract (mean wheal size, 5 mm). We performed an ELISA to detect specific IgE antibody (Ab) to mulberry fruit extract in the patient's serum compared to those of non-atopic healthy controls and birch-sensitized individuals. Specific IgE Ab to mulberry fruit extract was detected in the patient's serum, as compared to non-atopic healthy controls. Another subject, who was strongly sensitized to birch pollen, also had a positive serum-specific IgE Ab to mulberry fruit. We performed IgE immunoblot analysis using the patient's and the other subject's sera, who had serum-specific IgE to mulberry fruit, to identify the IgE-binding component. An identical IgE-binding component to mulberry extract was detected in the two subjects at around 17 kDa, and which might be PR 10 of Bet v 1. In conclusion, mulberry fruit could induce a systemic allergic reaction through an IgE-mediated mechanism, and cross-reactivity might occur between mulberry fruit and birch pollen.

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Identification of Bet v 1‐related allergens in fig and other Moraceae fruits

Abstract: Fig and other Moraceae fruits contain allergens homologous to Bet v 1 and represent clinically relevant birch pollen-associated foods.

Cited by 28 publications

References 25 publications

Position paper of the EAACI: food allergy due to immunological cross‐reactions with common inhalant allergens

Position paper of the EAACI: food allergy due to immunological cross‐reactions with common inhalant allergens

Unusual sensitization to parvalbumins from certain fish species

An IgE-Mediated Allergic Reaction Caused by Mulberry Fruit

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