Identification of Antifungal Compounds fromFerula persica. var.persica.

Abstract

In this investigation, the antifungal activities of chloroform and water extracts of Ferula persica. var. persica. Willd. roots were studied using conventional disk diffusion method. The chloroform extract showed antifungal activity at concentrations tested. Bioassay-guided fractionation study of the chloroform extract by preparative thin-layer chromatography (PTLC) detected two antifungal fractions that were effective against some fungi. Using conventional spectroscopy methods, the active fractions were identified as t-butyl 3-[(1-methylpropyl)dithio]-2-propenyl malonate (persicasulfide A) (1) and t.-butyl 3-[(1-methylthiopropyl)dithio]-2-propenyl malonate (persicasulfide B) (2), recently isolated from Ferula persica. var. latisecta.. These compounds showed the most potent antifungal activity with MICs of ≤ 62.5 µg/ml against filamentous fungi.

Composition and Antimicrobial Activity of the Oils ofFerula szowitsianaDC. from Turkey

“…persica Willd. (extracts) (35), F. kuhistanica Korovin (fruit extract) (36) and F. communis Linn. (sesquiterpenes from rhizomes) have been reported (37).…”

Essential oil composition and antimicrobial activity of Sphallerocarpus gracilis seeds against selected food-related bacteria

“…The antimicrobial activity of the essential oil and plant extracts of S. gracilis has not been studied up to now. However, it was previously reported that the essential oil or extracts of some members of the Apiaceae family, such as Ferula gummusa, Hippomarathrum microcarpum and Ferula persica (Eftekhar, Yousefzadi, & Borhani, 2004;Mirjani, Shahverdi, Iranshahi, Amin, & Shafiee, 2005;Ozer et al, 2007), had antimicrobial activity.…”

Antigenotoxic Effects of the Disulfide Compound Persicasulfide A (PSA) on Rat Lymphocytes Exposed to Oxidative Stress

“…Numerous reports have demonstrated that plant products possess a variety of in vitro antioxidant properties and that the consumption of food or beverages rich in antioxidant phytochemicals resulted in positive effects on human health and on the aging process [8], [9]. It has been shown that PSA has antifungal activity [10]. It has also been reported to inhibit matrix metalloproteinase activity [11].…”