Antigenotoxic Effects of the Disulfide Compound Persicasulfide A (PSA) on Rat Lymphocytes Exposed to Oxidative Stress

Noroozi, Saeid; Mosaffa, Fatemeh; Soltani, Fatemeh; Iranshahi, Mehrdad; Karimi, Gholamreza; Malekaneh, Mohammad; Haghighi, Fatemeh; Behravan, Javad

doi:10.1055/s-0028-1088360

Cited by 7 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress damages proteins, DNA, membrane lipids, and cellular organelles directly affects the progress of early aging, cancers, cardiovascular, neurological, and degenerative diseases [24]. The antioxidant activity of several natural compounds has been previously reported by Mosaffa et al [25,26]. In this study, we investigated the antioxidant activity of herniarin, which is in line with past studies [27,28].…”

Section: Discussionsupporting

confidence: 70%

The Effect of Herniarin on Spatial Working Memory, Pain Threshold, and Oxidative Stress in Ischemic Hypoperfusion Model in Rats

Barchestani

Rafieirad

2021

Caspian J Neurol Sci

View full text Add to dashboard Cite

Background: Ischemia causes severe neuronal damage and induces oxidative stress, memory impairment, and reduces pain threshold. Herniarin is a powerful antioxidant. Objectives: This study aimed to evaluate the effect of herniarin on memory, pain, and oxidative stress in an ischemia model in male rats. Materials & Methods: In this study, 50 male rats were divided into 5 groups of control, sham, ischemic, and two other ischemic groups, which received herniarin at doses of 150 and 300 mg/kg by gavage for 14 days. Behavioral tests were performed by shuttle box, and Y-maze and pain tests were performed by Tail-Flick test. Then, the rats’ brains were extracted to evaluate lipid peroxidation and measure the levels of thiol and Glutathione Peroxidase (GPX) in the hippocampus and striatum tissues. The results were expressed as Mean±SEM and then analyzed using suitable statistical methods of ANOVA and least significant difference post-hoc test in SPSS V. 20. Results: Herniarin significantly increased the avoidance memory, spatial memory, and pain thresholds of ischemic rats at different concentrations (P<0.001). Besides, the amount of malondialdehyde (MDA) and thiol in the ischemic group increased significantly in comparison to the control group (P<0.001). Also, in the ischemic group, GPX (P<0.001) significantly decreased. Decreased MDA (P<0.001) and thiol (P<0.001) and increased GPX levels were observed with herniarin administration (P<0.01). Conclusion: According to this study’s results, herniarin can remove free radicals and oxidant substances from the brain. Thus, it improves memory and pain thresholds in the brain hypoperfusion ischemia model.

show abstract

Section: Discussionsupporting

confidence: 70%

The Effect of Herniarin on Spatial Working Memory, Pain Threshold, and Oxidative Stress in Ischemic Hypoperfusion Model in Rats

Barchestani

Rafieirad

2021

Caspian J Neurol Sci

View full text Add to dashboard Cite

show abstract

“…Mutation and increased cell proliferation are the main causes of carcinogenesis induced by DNA damage (Klaunig & Kamendulis, 2004;Wiseman et al, 1995). The antigenotoxic activity of several natural compounds has been previously reported by Mosaffa et al (Mosaffa et al, 2006;Noroozi et al, 2009). In this study, we investigated the antigenotoxic activity of UMB, HER and 7-IP, using comet assay, which is a sensitive and feasible genotoxic assay (Valverde et al, 1999).…”

Section: Discussionmentioning

confidence: 95%

Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress

Rezaee

Behravan

et al. 2013

Drug and Chemical Toxicology

Self Cite

View full text Add to dashboard Cite

The antigenotoxic effects of umbelliferone (UMB), herniarin (HER) and 7-isopentenyloxy coumarin (7-IP), common natural dietary coumarins, were evaluated on the human lymphocyte DNA damage using single-cell gel electrophoresis. H(2)O(2)-induced DNA break was measured based on the percentage of DNA in tail, and the antigenotoxic effects of the tested compounds were compared with that of ascorbic acid (10, 25, 50, 100 and 200 μM). UMB, HER and 7-IP did not show any genotoxicity, as compared to phosphate-buffered saline. Treatment with UMB, HER and 7-IP led to a significant reduction in the percentage of DNA in tail induced by H(2)O(2) (p < 0.001) at all concentrations. The presence of prenyl moiety in the chemical structure of 7-IP may contribute to its better antigenotoxic property, compared to UMB. The results of this study showed that 7-IP possessed the best antigenotoxic activity among the tested compounds.

show abstract

“… Euphorbiaceae Spurge Farfion Gum Oral AI/ in vitro 69 Ferula persica Willd. Apiaceae Ferula Sakbinaj Gum Oral AO/ in vitro 70 Dorema ammoniacum D. Don. Apiaceae Ammoniac Gum Oshagh Gum Oral and topical NP/ in vitro 71 a AO: antioxidant; AI: anti-inflammatory; AG: analgesic; NP: neuroprotective.…”

Section: Carpal Tunnel Syndrome In Avicenna's Canon Of Medicinementioning

confidence: 99%

New candidates for treatment and management of carpal tunnel syndrome based on the Persian Canon of Medicine

Setayesh

Zargaran

Sadeghifar

et al. 2018

Integrative Medicine Research

View full text Add to dashboard Cite

Carpal tunnel syndrome (CTS) is defined as a compressing median mononeuropathy. CTS is one of the major costly debilitating diseases of the hand. Although CTS is a relatively recent concept in current medicine, some evidences show that medieval physicians in Persian medicine (PM) such as Avicenna were familiar with it. The PM textbook written by Avicenna, the Canon of Medicine, defines the anatomy of carpal tunnel and median nerve, as well as mononeuropathy; it also offers suggestions for the prevention and treatment of carpal tunnel syndrome (called as Vaja al-asab and Khadar) in the chapter of nerve diseases. The book describes not only symptoms including pain, paresthesia, hypoesthesia, tingling, and numbness, but also its etiology such as nerve compression (entrapment neuropathy); nonphysical reasons such as disturbed balance among the four body humors; alteration in the nerve's temperament (Mizaj) that prevents the transmission of nerve impulses; and the others such as nutrition, mental condition, sleep, weather condition, body movements, and proper disposal of body waste. Furthermore, the book suggests a lifestyle modification method based on six factors and 10 prescriptions composed with 85 natural products that are not actively used for CTS treatment in modern times. The medicinal suggestions for CTS in the Canon of Medicine will be good candidates for discovering new treatments besides providing historical significance to the various insights considered 1000 years ago.

show abstract

Antigenotoxic Effects of the Disulfide Compound Persicasulfide A (PSA) on Rat Lymphocytes Exposed to Oxidative Stress

Cited by 7 publications

References 26 publications

The Effect of Herniarin on Spatial Working Memory, Pain Threshold, and Oxidative Stress in Ischemic Hypoperfusion Model in Rats

The Effect of Herniarin on Spatial Working Memory, Pain Threshold, and Oxidative Stress in Ischemic Hypoperfusion Model in Rats

Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress

New candidates for treatment and management of carpal tunnel syndrome based on the Persian Canon of Medicine

Contact Info

Product

Resources

About