Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress

Rezaee, Ramin; Behravan, Effat; Behravan, Javad; Soltani, Fatemeh; Naderi, Yazdan; Emami, Bahareh; Iranshahi, Mehrdad

doi:10.3109/01480545.2013.834352

Cited by 46 publications

(21 citation statements)

References 37 publications

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“…This suggests that these extracts may interact and neutralize electrophiles such as nitrofurantoin, or may inhibit microsomal activation of aflatoxin B1 to electrophilic metabolites. The antigenotoxic and antimutagenic activities of the tested extracts may be ascribed to flavonoids (Bhouri et al, 2011), coumarins (Rezaee et al, 2014), and tannins (Buyukleyla et al, 2012) detected in the aqueous and TOF extracts. The observed protective effect of aqueous and TOF extracts towards mutagenic agents may correspond to a synergic participation of several of the compounds listed above.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Mokdad-Bzéouich

Kilani-Jaziri

Mustapha

et al. 2015

Pharmaceutical Biology

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Context: The leaves of Eriobotrya japonica (Thunb.) Lindl. (Rosaceae) are used in traditional medicine to treat inflammatory diseases. However, information about the antigenotoxic and antioxidant properties of its leaves remains to be elucidated. Objective: The objective of this work was to evaluate the mutagenic/antimutagenic, genotoxic/ antigenotoxic, and antioxidant potentials of aqueous and total oligomers flavonoid (TOF) extracts from E. japonica. Materials and methods: The mutagenic/antimutagenic and genotoxic/antigenotoxic potentials of extracts (50, 250, and 500 mg/plate) were evaluated, respectively, by the Ames test with 48 h incubation and the SOS chromotest test with 2 h incubation. The antioxidant capacity of these extracts (ranging from 50 to 700 mg/mL) was tested using xanthine/xanthine oxidase and the deoxyribose assays. Results: Eriobotrya japonica extracts showed neither mutagenic nor genotoxic effect. The highest protective effect against methyl methanesulfonate and 2-aminoanthracene was obtained in the presence of aqueous extract, with IC 50 values of 80 and 140 mg/plate, respectively, against S. typhimurium TA104. Moreover, this extract (500 mg/plate) was also able to reduce significantly the genotoxicity induced by nitrofurantoin and aflatoxin B1 with IC 50 values of 140 and 240 mg/assay, respectively. Likewise, aqueous and TOF extracts inhibited xanthine oxidase and superoxide anion formation with IC 50 values ranging from 45 to 95 and from 70 to 90 mg/mL, respectively. However, TOF extract is more efficient in inhibiting hydroxyl radical and chelating iron ion with IC 50 values of 140 and 400 mg/mL, respectively, when compared with the aqueous extract. Conclusion: Eriobotrya japonica prevents the genotoxicity of some carcinogenic substances probably thanks to its antioxidant capacities.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Mokdad-Bzéouich

Kilani-Jaziri

Mustapha

et al. 2015

Pharmaceutical Biology

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“…Oxidative stress is able to damage cell components (e.g., proteins, DNA and lipids) and organelles (56) and has been shown to be related with various pathological conditions (57,58); increased oxidative stress leads to neuronal death by damaging brain cellular lipids, proteins and nucleic acids and induces apoptosis through the transcription of the pro-apoptotic BID and BAD factors (59). Yavuz et al demonstrated that a single dose of MS reduced brain oxidative stress following CO poisoning and that the intraperitoneal administration of MS at 100 mg/kg was sufficient to significantly decrease lipid peroxidation (60).…”

Section: Discussionmentioning

confidence: 99%

Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats

et al. 2018

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Carbon monoxide (CO) has been shown to induce several cardiovascular abnormalities, as well as necrosis, apoptosis and oxidative stress in the brain. Magnesium sulfate (MS) has been shown to have beneficial activities against hypoxia in the brain. In the present study, the possible protective effects of MS against CO-induced cerebral ischemia were investigated. For this purpose, 25 male Wistar rats were exposed to 3,000 ppm CO for 1 h. The animals were divided into 5 groups (n=5 in each group) as follows: The negative control group (not exposed to CO), the positive control group (CO exposed and treated with normal saline), and 3 groups of CO-exposed rats treated with MS (75, 150 and 300 mg/kg/day) administered intraperitoneally for 5 consecutive days. On the 5th day, the animals were sacrificed and the brains were harvested for the evaluation of necrosis, apoptosis and oxidative stress. Histopathological evaluation revealed that MS reduced the number and intensity of necrotic insults. The Bax/Bcl2 ratio and malondialdehyde (MDA) levels were significantly decreased in a dose-dependent manner in the MS-treated rats compared to the positive control group, while a significant dose-dependent increase in Akt expression, a pro-survival protein, was observed. In addition, MS administration reduced pro-apoptotic indice levels, ameliorated histological insults, favorably modulated oxidative status and increased Akt expression levels, indicating a possible neuroprotective effect in the case of CO poisoning. On the whole, the findings of this study indicate that MS may prove to be useful in protecting against CO-induced cerebral injury.

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“…Investigations indicate that prenyl moieties (3-methyl-2-buten-1-yl; bolded side chain in Fig. 1 ) in the terpenoid coumarins have an important role in biological activities of this group of natural compounds ( 19 20 ). It is considered that the prenyl moiety facilitate attachment of the bioactive molecules to cysteine residues of intercellular proteins ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Antileishmanial activity of prenylated coumarins isolated from Ferulago angulata and Prangos asperula

Sajjadi¹,

Eskandarian²,

Shokoohinia³

et al. 2016

Res Pharma Sci

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Leishmaniasis has a wide spectrum of signs and symptoms due to infection to numbers of Leishmania species and makes enormous mortality and morbidity. There are clues of antileishmanial effects of prenylated coumarins. Apiaceae family is one of the most important sources of coumarins. Air-dried aerial parts of Ferulago angulata and fruits of Prangos asperula were extracted with n-hexane, using a soxhlet apparatus. The solvents were evaporated under reduced pressure. Column chromatography and crystallization process resulted to isolation of three prenylated coumarins. 1H-nuclear magnetic resonance, electron ionization Mass and Infrared spectra were used for elucidation of isolated compounds. Leishmanicidal activity of isolated coumarins was assessed on Leishmania major strain (MRHO/IR/75/ER) for the first time. Suberosin epoxide and suberosin were isolated from aerial parts of F. angulata and osthol was extracted from grounded fruits of P. asperula. Osthol showed a significant antileishmanial effect on promastigotes in early hours of exposure with IC50 of 14.40 µg/mL but suberosin epoxide showed only a weak antileishmanial activity. IC50 of osthol and suberosin epoxide after 48 h were 10.79 and 54.0 µg/mL, respectively. Suberosin showed no remarkable effect in these concentrations. This is the first report on the pharmacological activity of suberosin epoxide. Substantial difference between efficacies of two isomers, osthol and suberosin remarks the importance of prenyl substituent location on C-8.

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Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress

Cited by 46 publications

References 37 publications

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats

Antileishmanial activity of prenylated coumarins isolated from Ferulago angulata and Prangos asperula

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