“…The consideration of teak in Natural Products research is based on its ethnobotanical uses, the biological activity shown by its extracts, and the durability of its wood (e.g., Ahuwalia and Seshadri, 1957;Rudman, 1960;Joshi et al, 1977;Marwani et al, 1997;Khan and Mlungwana, 1999;Macías et al, 2008Macías et al, , 2010Sumthong et al, 2008;Naira and Kaverkar, 2010;Singh et al, 2010;Shukla et al, 2010). In addition to the value of the cultivation of T. grandis as source of wood and the extension of forest areas, it also has become an efficient tool for pest control in the context of a sustainable agriculture.…”
Two new quinones, (an isoprenoid quinone, and a dimeric anthraquinone) named naphthotectone and anthratectone, respectively, were isolated from bioactive leaf extracts from Tectona grandis. Their structures were determined by a combination of 1D and 2D NMR techniques. The bioactivity profile of naphthotectone was assessed using the etiolated wheat coleoptiles bioassay in aqueous solutions at concentrations ranging from 10(-3) to 10(-5)M, as well as the standard target species lettuce, cress, tomato, and onion. Naphthotectone showed high level of activities in both bioassays. This fact, along with the presence of this compound as the major component in Tectona grandis, suggests that it may be involved in the allelopathic activity previously described for this species, and probably in other defense mechanisms.
“…The consideration of teak in Natural Products research is based on its ethnobotanical uses, the biological activity shown by its extracts, and the durability of its wood (e.g., Ahuwalia and Seshadri, 1957;Rudman, 1960;Joshi et al, 1977;Marwani et al, 1997;Khan and Mlungwana, 1999;Macías et al, 2008Macías et al, , 2010Sumthong et al, 2008;Naira and Kaverkar, 2010;Singh et al, 2010;Shukla et al, 2010). In addition to the value of the cultivation of T. grandis as source of wood and the extension of forest areas, it also has become an efficient tool for pest control in the context of a sustainable agriculture.…”
Two new quinones, (an isoprenoid quinone, and a dimeric anthraquinone) named naphthotectone and anthratectone, respectively, were isolated from bioactive leaf extracts from Tectona grandis. Their structures were determined by a combination of 1D and 2D NMR techniques. The bioactivity profile of naphthotectone was assessed using the etiolated wheat coleoptiles bioassay in aqueous solutions at concentrations ranging from 10(-3) to 10(-5)M, as well as the standard target species lettuce, cress, tomato, and onion. Naphthotectone showed high level of activities in both bioassays. This fact, along with the presence of this compound as the major component in Tectona grandis, suggests that it may be involved in the allelopathic activity previously described for this species, and probably in other defense mechanisms.
“…1 ). Previous phytochemical investigation of teak leaves also led to the isolation of triterpenoids [ 4 ], anthraquinones [ 6 – 8 ] and naphthoquinones [ 9 , 10 ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In the Northern part of Cameroon, leaves of teak are used for their laxative properties while in the Western Region, it is used for the treatment of skin diseases. Previous phytochemical investigation of Tectona species have led to the isolation of triterpenoids, flavonoïds [ 4 ], chromomoric acid derivatives [ 5 ], anthraquinones [ 6 – 8 ], naphthoquinones [ 9 , 10 ], anthraquinone-naphthoquinones [ 11 , 10 ], apocarotenoids [ 1 ] and lignans [ 12 ]. Some of these metabolites particularly the quinines showed antimycobacterial, antifungal and allelopathic activities [ 7 , 9 , 11 , 1 , 10 ].…”
BackgroundWell known as teak, Tectona grandis is widely used in African folk medicine for its pharmacological relevance. In Cameroon, this species is a reputed laxative in the Northern Region while in the Western Region, it is used in the treatment of skin diseases and diarrhoea.Materials and methodsSeparation and isolation of compounds were performed using different chromatographic methods while their structures were elucidated by spectroscopic techniques including MS and NMR, and by comparison of data with those reported in the literature. Isolated compounds as well as crude ethanol extract were tested for their antibacterial activities using broth micro-dilution method against four Gram negative bacteria strains Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (PA 01), Klebsiella pneumonia (ATCC 11296) and Escherichia aerogenes (ATCC 13048).ResultsThree known compounds were isolated, including two quinones and one triterpene. They were identified as tectograndone (1), 6-methyl-1,4-dihydroxyanthraquinone (2), and 2β-hydroxyursolic acid (3) respectively. Crude ethanol extract showed good activity against the bacteria strains tested with MIC of 64–256 μg/mL. Among the isolated metabolites, 6-methyl-1,4-dihydroxyanthraquinone exhibited a strong activity against Escherichia aerogenes with MIC of 16 μg/mL, while tectograndone showed a moderate activity against Escherichia coli with MIC of 32 μg/mL. The antibacterial screening of the fruits of this plant as well as that of compounds 1 and 2 is reported herein for the first time.ConclusionThe research work presented here shows that Tectona grandis fruits possess compounds which could be developed in the treatment of bacterial diseases.
“…Teak is one of the world's premier hardwood tree species, highly famous for its quality, profile and durability of timber (Sumthong et al 2008). The generic name of T. grandis comes from "Tekka", which is the Malabar name while the specific name, "grandis" is a Latin word for "large" or "great".…”
Bacteria were isolated from decayed food samples (tomatoes, cooked beans and rice) collected from Afe Babalola University, Ado Ekiti (ABUAD) cafeteria and characterized. Some of these isolated microorganisms could pose serious harm to humans including animals and they are normally treated with commercial antibiotics. However, the majority of bacteria are resistant to many antibiotics therefore, the use of plant extracts with therapeutic potential against resistant bacteria is necessary. In this investigation, eight bacteria were isolated from decayed food samples. The bacterial isolates were identified as Bacillus cereus and B. siamensis from rice sample; Klebsiella oxytoxa, Salimicrobium halophilium and Norcardia brasiliensis from beans sample; Bacillus subtilis, Enterobacter taylore, and Brevibacillus agri from tomatoes. The leaf samples of Tectona grandis were screened qualitatively and quantitatively for the phytochemicals while the crude methanol and chloroform extracts were used as antimicrobial agents against the isolated microorganisms. Alkaloids, carotenoids and tannins were present in large amount. The bacterial isolates were more susceptible to commercial antibiotics than that of methanol extracts of T. grandis. The methanol extracts of T. grandis have a higher antimicrobial activity than the chloroform extracts.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
