Identification of an Invasive, N-Cadherin-Expressing Epithelial Cell Type in Endometriosis Using a New Cell Culture Model

Neoexpression of N‐cadherin in E‐cadherin positive colon cancers

“…Inappropriate mesenchymal cadherin expression, such as Ncadherin or cadherin-11, has been reported in breast, 7,61,62 prostate 8 and gastric cancer, 15,63 as well as in renal cancer 64 and Melanoma 11 and was linked to increased invasiveness and metastasis. Zeitvogel et al 65 identified an invasive, N-cadherin expressing cell type in endometriosis, a benign disease.…”

Role of tissue stroma in cancer cell invasion

“…Highly invasive cancer cells express N-cadherin at the tips of their highly motile filopodia that probe and sense the environment by forming transient contacts with surrounding cells and with the ECM [169]. In such way cancer cells may dock to myofibroblasts.…”

Tumor Necrosis Factor-α Regulates Inflammatory and Mesenchymal Responses via Mitogen-Activated Protein Kinase Kinase, p38, and Nuclear Factor κB in Human Endometriotic Epithelial Cells

“…Recently, a set of immortalized endometriotic epithelial cells and stromal cells have been developed and shown to exhibit many characteristics of primary epithelial and stromal endometriotic cells (Zeitvogel et al, 2001). The availability of these cells has enabled investigation of direct pharmacologic responses of isolated endometriotic epithelial and stromal cells.…”