Identification of an immunodominant IgE epitope of Der p 39, a novel allergen of Dermatophagoides pteronyssinus

Li, Weiyong; Cai, Zelang; Zhang, Bo‐Ping; Chen, Jiajie; Ji, Kunmei

doi:10.1016/j.waojou.2022.100651

Cited by 5 publications

(2 citation statements)

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“…According to http://allergen.org/ , the official website of allergens systematic classification, approved by the WHO and the Allergen Nomenclature Sub-committee of the International Union of Immunological Societies (WHO/IUIS), Dermatophagoides pteronyssinus (European house dust mite) alone contains 32 allergenic proteins and Dermatophagoides farinae (American house dust mite) has 37 such proteins [ 6 ]. The discovery of new allergenic molecules of these mites continues [ 7 ]. Two more mite species, Euroglyphus maynei and Dermatophagoides microceras , contain 5 and 2 currently detected molecular allergens respectively.…”

Section: Introductionmentioning

confidence: 99%

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

et al. 2023

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Background As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective. Methods The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization. Results Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6. Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen. Conclusion The results obtained indicate the importance of determining the sensitization profile using the multi-component approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.

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Section: Introductionmentioning

confidence: 99%

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

et al. 2023

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“…There is a plethora of literature that evaluates molecular profiles of IgE and IgG4 recognition during AIT [ 13 , 14 ], especially subcutaneous. Epitope mapping goes back approximately 30 years [ 15 ], some previous works have identified epitopes in HDM allergens, such as Der p 5 [ 16 ], Der p 7 [ 17 ], Der p 2 [ 18 , 19 ], Der p 39 [ 20 ], and Blo t 11 [ 21 ] to characterize IgE only or IgE and IgG binding sites by various methods. Other studies used epitope mapping with the objective of investigating antibody cross-reactivity among different molecules [ 22 , 23 , 24 ]; Yi et al evaluated similarities between Blo t 10 and Der p 10 [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

IgE and IgG4 Epitopes of Dermatophagoides and Blomia Allergens before and after Sublingual Immunotherapy

Figo

Macedo

Gadermaier

et al. 2023

IJMS

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Sublingual immunotherapy (SLIT) is used worldwide to treat house dust mites (HDM) allergy. Epitope specific immunotherapy with peptide vaccines is used far less, but it is of great interest in the treatment of allergic reactions, as it precludes the drawbacks of allergen extracts. The ideal peptide candidates would bind to IgG, blocking IgE-binding. To better elucidate IgE and IgG4 epitope profiles during SLIT, sequences of main allergens, Der p 1, 2, 5, 7, 10, 23 and Blo t 5, 6, 12, 13, were included in a 15-mer peptide microarray and tested against pooled sera from 10 patients pre- and post-1-year SLIT. All allergens were recognized to some extent by at least one antibody isotype and peptide diversity was higher post-1-year SLIT for both antibodies. IgE recognition diversity varied among allergens and timepoints without a clear tendency. Der p 10, a minor allergen in temperate regions, was the molecule with more IgE-peptides and might be a major allergen in populations highly exposed to helminths and cockroaches, such as Brazil. SLIT-induced IgG4 epitopes were directed against several, but not all, IgE-binding regions. We selected a set of peptides that recognized only IgG4 or were able to induce increased ratios of IgG4:IgE after one year of treatment and might be potential targets for vaccines.

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Expression, purification, and activity of novel allergen Tyr p 31 from Tyrophagus putrescentiae

Zhou,

Ren,

Zhou

et al. 2024

International Journal of Biological Macromolecules

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Identification of an immunodominant IgE epitope of Der p 39, a novel allergen of Dermatophagoides pteronyssinus

Cited by 5 publications

References 44 publications

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

IgE and IgG4 Epitopes of Dermatophagoides and Blomia Allergens before and after Sublingual Immunotherapy

Expression, purification, and activity of novel allergen Tyr p 31 from Tyrophagus putrescentiae

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