Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

Abstract

Background As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective. Methods The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization. Results Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6. Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen. Conclusion The results obtained indicate the importance of determining the sensitization profile using the multi-component approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.

Sensitization patterns to Poaceae pollen indicates a hierarchy in allergens and a lead of tropical grasses

“…Previous papers used BN as a decision support system determining the skin 24,25 (and house dust mite sensitization). 26 However, application of Bayesian modelling for the healthcare systems seems to be useful and needs further clinical adoption 27 This was shown in this study as many of the patterns found by the BN are consistent with the known clinical data. For example, modelling suggested that while affecting the development of sensitization to other allergens, Phl p 2 itself was not affected by them.…”

“…To our knowledge, this is the first paper in the world which uses a BN in order to establish the hierarchy in the sensitization to grass allergens. Previous papers used BN as a decision support system determining the skin 24,25 (and house dust mite sensitization) 26 . However, application of Bayesian modelling for the healthcare systems seems to be useful and needs further clinical adoption 27 …”

Mite allergen sensitization patterns in Turkish children: Age‐related changes and molecular correlations

“…In previous studies, the prevalence of Der p 23 varied among patient cohorts 9,30–32 . A recent study conducted in Ukraine noted that sensitivity to Der p23 becomes evident in the first year of life 33 . This suggests that factors such as geographical region and age may significantly influence sensitization to Der p 23, while the prevalence of Der p 1 or Der p 2 is less affected 34 …”

“…9,30-32 A recent study conducted in Ukraine noted that sensitivity to Der p23 becomes evident in the first year of life. 33 This suggests that factors such as geographical region and age may significantly influence sensitization to Der p 23, while the prevalence of Der p 1 or Der p 2 is less affected. 34 In the Italian study by Celi et al, Der p 23 was identified as a risk factor for asthma, particularly severe asthma, 35 while Villalta found a stronger association between Der p 23 and rhinitis.…”

Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens in the Lithuanian population: Understanding allergic sensitization patterns

“…8 While group A molecules (Der p 1, Der p 2, and Der p 23) have long been recognized as primary Der p sensitization triggers 6,[8][9][10] and have been at the epicenter of HDM epidemiological studies for many years, our knowledge on group B allergen (Der p 5, Der p 7, and Der p 21) prevalence is still lacking. 8,10,11 As sensitization patterns of mite-allergic patients are influenced by age, gender, heredity, and mite exposure 8,10 it is important to define Lithuanian population sensitization profiles to gain a better understanding of worldwide Der p sensitization trends. [12][13][14][15] The aim of this study was to assess the sensitization profiles to MA's derived from house dust mite (Dermatophagoides pteronyssinus) in the Lithuanian population.…”