Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection

Hadwiger, Michael E.; Trehy, Michael L.; Ye, Wei; Moore, Terry W.; Allgire, James F.; Westenberger, Benjamin J.

doi:10.1016/j.chroma.2010.10.018

Cited by 87 publications

(68 citation statements)

References 8 publications

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“…These labeling inaccuracies also extend to EC components other than nicotine. For example, cartridge fluid from one EC product that was advertised to contain tadalafil, the active ingredient in Cialis, instead contained an inactive isoform of the drug (Hadwiger et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Behar

Davis

Wang

et al. 2014

Toxicology in Vitro

225

211

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a b s t r a c tIn a prior study on electronic cigarette (EC) refill fluids, Cinnamon Ceylon was the most cytotoxic of 36 products tested. The purpose of the current study was to determine if high cytotoxicity is a general feature of cinnamon-flavored EC refill fluids and to identify the toxicant(s) in Cinnamon Ceylon. Eight cinnamon-flavored refill fluids, which were screened using the MTT assay, varied in their cytotoxicity with most being cytotoxic. Human embryonic stem cells were generally more sensitive than human adult pulmonary fibroblasts. Most products were highly volatile and produced vapors that impaired survival of cells in adjacent wells. Cinnamaldehyde (CAD), 2-methoxycinnamaldehyde (2MOCA), dipropylene glycol, and vanillin were identified in the cinnamon-flavored refill fluids using gas chromatography-mass spectrometry and high-pressure liquid chromatography (HPLC). When authentic standards of each chemical were tested using the MTT assay, only CAD and 2MOCA were highly cytotoxic. The amount of each chemical in the refill fluids was quantified using HPLC, and cytotoxicity correlated with the amount of CAD/ product. Duplicate bottles of the same product were similar, but varied in their concentrations of 2MOCA. These data show that the cinnamon flavorings in refill fluids are linked to cytotoxicity, which could adversely affect EC users.

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Section: Discussionmentioning

confidence: 99%

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Behar

Davis

Wang

et al. 2014

Toxicology in Vitro

225

211

View full text Add to dashboard Cite

show abstract

“…regard to allergenic flavors, contaminants as well as additives that may encompass pharmacologically active compounds (Hadwiger et al 2010). A proper risk assessment also requires further caution as users may have the possibility to modify commercial liquids when using refillable cartridges.…”

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confidence: 99%

E-cigarettes in Europe: does regulation swing from overcautious to careless?

Henkler

Luch

2014

Arch Toxicol

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“…12 Although the sale of e-cigarettes is prohibited in some countries (Australia, Brazil, Canada, Mexico, Panama, Singapore, and Switzerland), it is allowed in most others, including the United States. 13 The number of e-cigarettes sold has increased exponentially year by year. Wells Fargo has predicted that sales margins for e-cigarettes could grow to $10 billion by 2017, surpassing conventional cigarette sales margins.…”

mentioning

confidence: 99%