Identification of Agronomic Traits of Centella asiatica (L.) Urban. Naturally Grown at Regions With Different Altitudes

Halimi, Entis Sutisna

doi:10.31258/jnat.13.3.232-236

Cited by 6 publications

(3 citation statements)

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“…A dose of 81 kg ha−1 at an altitude of 450 m asl gave the highest fresh weight yield, but it was not significantly different than a dose of 54 at an altitude of 900 m asl. Halimi [33] stated that was an indication that the leaves of the plants grown in mid-and highland regions were larger in size with shorter petiole compared to plants in lower regions. The increase in P fertilizer would increase the dry weight of C. asiatica and the content of asiaticoside [34,35].…”

Section: Performance Growth and Productivity Of C Asiaticamentioning

confidence: 99%

The Effect of P2O5 Fertilizer, Zeolite, and Volcanic Soil Media from Different Altitudes on the Soil Mineral, Growth, Yield, and Asiaticoside Content of Centella asiatica L.

et al. 2022

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Centella asiatica is an herbal plant with many health benefits due to the content of asiaticoside compounds. Factors affecting asiaticoside content are altitude, soil texture, and soil nutrient status. This research aimed to identify the effect of zeolite, P2O5 fertilizer, and soil media from different altitudes on C. asiatica. The research was conducted in a greenhouse from August 2017–June 2018. The experimental design was a factorial, completely randomized design with three factors and four replications. The first factor was soil media that originated from 100, 450, and 900 m above sea level (asl), the second factor was the dose of P2O5 fertilizer (0, 27, 54, and 81 kg ha−1), and the third was the dose of zeolite (0, 3, and 6 t ha−1). The results showed that applying zeolite minerals at all altitudes increased nutrient availability and soil cation exchange capacity (CEC) by up to 70%. The novelty of this study is that the soil from an altitude of 900 m asl, with a P2O5 fertilizer dose of 54 kg ha−1, has a loamy sand soil texture and produces the highest asiaticoside content (3.61%) and the largest plant dry weight (19.24 g). These results did not significantly differ from those obtained from the soil 450 m asl with a sandy loam soil texture (the most suitable soil texture for C. asiatica), that is 3.37% asiaticoside and 19.87 g plant dry weight. This study concluded that C. asiatica could develop in loamy sand soil by giving it 54 kg ha−1 P2O5 fertilizer.

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Section: Performance Growth and Productivity Of C Asiaticamentioning

confidence: 99%

The Effect of P2O5 Fertilizer, Zeolite, and Volcanic Soil Media from Different Altitudes on the Soil Mineral, Growth, Yield, and Asiaticoside Content of Centella asiatica L.

et al. 2022

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“…However, the wild stock of C. asiatica has been markedly depleted due to large scale and unrestricted exploitation with very limited cultivation [10]. Halimi [11] reported that C. asiatica can be grown in lowland, midland, and highland in Indonesia. However, C. asiatica required sufficient nutrient availability for obtaining high yield and maintaining the quality of its active principles [12].…”

Section: Introductionmentioning

confidence: 99%

Growth and Secondary Metabolites Production of Centella asiatica (L.) Urb. Cultivated at Different Phosphate Application Rates in Acid Soil

Vinolina

Sigalingging

2022

Trends Sci

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Centella asiatica (L.) Urb. is a widely known medicinal plant for dermatological and non-dermatological diseases. The demand for C. asiatica extracts continues to increase but its availability is markedly depleted due to exploitation and limited cultivation. This study was conducted to evaluate the phosphate growth responses and variation of secondary metabolites production of C. asiatica cultivated at different phosphate application rates in acid soil in Indonesia. The soil pH used in this study was 2.76. Rates of phosphate application were 0 kg per plant as control plant, 20, 40, 60, 80 and 100 kg ha-1, respectively. Results showed that the plants applied with 40 kg ha-1 phosphate resulted in the highest number of leaves, petiole length, total leaf area, and number of tendrils and stolons which lead to the higher biomass. C. asiatica produced various types of secondary metabolites, i.e asiaticoside, madecassoside, asiatic acid, saponin, tannin, phenolic, flavonoid, triterpenoid, steroid, and glycoside. The production of secondary metabolites was optimized by the application of 20 kg ha-1 phosphate. It can be concluded that the application low dosage of phosphate can enhance the growth and secondary metabolites production of C. asiatica cultivated in acid soil. HIGHLIGHTS Gotu kola is well-known medicinal plant that has which has been used for generations and its benefits has been confrmed by the consumers Gotu kola can grow in both lowlands and highlands but the centellosides contents in gotu kola affected by the growing medium and phosphorus application The demand for simplicia is increasing, while the availability of gotu kola is limited in nature may cause gotu kola become rare and even endangered. Thus, it is necessary to cultivate gotu kola to maintain good quality and quantity The specific target to be achieved is the availability of gotu kola with optimal centelloside content GRAPHICAL ABSTRACT

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“…Generally, C. asiatica (L.) is a small perennial herbal plant with kidney-shaped leaves that belongs to the family Apiceae [10]. It grows in damp and swampy areas of tropical countries and is commonly known as pegaga in Malaysia, Indian Pennywort in the United States of America, yuhong-yuhong in the Philippines, tapak kuda in Indonesia and buak bok in Thailand [11, 12]. It has various therapeutic activities that are mainly attributed to its biologically active ingredients, i.e.…”

Section: Introductionmentioning

confidence: 99%

The effects of Centella asiatica (L.) Urban on neural differentiation of human mesenchymal stem cells in vitro

Omar

Lokanathan

Razi

et al. 2019

BMC Complement Altern Med

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Background Centella asiatica (L.) Urban, known as Indian Pennywort, is a tropical medicinal plant from Apiaceae family native to Southeast Asian countries. It has been widely used as a nerve tonic in Ayuverdic medicine since ancient times. However, whether it can substitute for neurotrophic factors to induce human mesenchymal stem cell (hMSCs) differentiation into the neural lineage remains unknown. This study aimed to investigate the effect of a raw extract of C. asiatica (L.) (RECA) on the neural differentiation of hMSCs in vitro. Methods The hMSCs derived from human Wharton’s jelly umbilical cord (hWJMSCs; n = 6) were treated with RECA at different concentrations; 400, 800, 1200, 1600, 2000 and 2400 μg/ml. The cytotoxicity of RECA was evaluated via the MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) and cell proliferation assays. The hWJMSCs were then induced to neural lineage for 9 days either with RECA alone or RECA in combination with neurotrophic factors (NF). Cell morphological changes were observed under an inverted microscope, while the expression of the neural markers S100β, p75 NGFR, MBP, GFAP and MOG was analyzed by quantitative polymerase chain reaction and immunocytochemistry. The cell cycle profile of differentiated and undifferentiated hWJMSCs was investigated through cell cycle analysis. Results RECA exerted effects on both proliferation and neural differentiation of hWJMSCs in a dose-dependent manner. RECA reduced the proliferation of hWJMSCs and was cytotoxic to cells above 1600 μg/ml, with IC 50 value, 1875 ± 55.67 μg/ml. In parallel with the reduction in cell viability, cell enlargement was also observed at the end of the induction. Cells treated with RECA alone had more obvious protein expression of the neural markers compared to the other groups. Meanwhile, gene expression of the aforementioned markers was detected at low levels across the experimental groups. The supplementation of hWJMSCs with RECA did not change the normal life cycle of the cells. Conclusions Although RECA reduced the proliferation of hWJMSCs, a low dose of RECA (400 μg/ml), alone or in combination of neurotrophic factors (NF + RECA 400 μg/ml), has the potential to differentiate hWJMSCs into Schwann cells and other neural lineage cells. Electronic supplementary material The online version of this article (10.1186/s12906-019-2581-x) contains supplementary material, which is available to authorized users.

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Identification of Agronomic Traits of Centella asiatica (L.) Urban. Naturally Grown at Regions With Different Altitudes

Cited by 6 publications

References 0 publications

The Effect of P2O5 Fertilizer, Zeolite, and Volcanic Soil Media from Different Altitudes on the Soil Mineral, Growth, Yield, and Asiaticoside Content of Centella asiatica L.

The Effect of P2O5 Fertilizer, Zeolite, and Volcanic Soil Media from Different Altitudes on the Soil Mineral, Growth, Yield, and Asiaticoside Content of Centella asiatica L.

Growth and Secondary Metabolites Production of Centella asiatica (L.) Urb. Cultivated at Different Phosphate Application Rates in Acid Soil

The effects of Centella asiatica (L.) Urban on neural differentiation of human mesenchymal stem cells in vitro

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