Identification of a strategic brain network underlying processing speed deficits in vascular cognitive impairment

Duering, Marco; Gonik, Mariya; Malik, Rainer; Zieren, Nikola; Reyes, Sergio; Jouvent, Éric; Hervé, Dominique; Gschwendtner, Andreas; Opherk, Christian; Chabriat, Hugues; Dichgans, Martin

doi:10.1016/j.neuroimage.2012.10.084

Cited by 67 publications

(55 citation statements)

References 53 publications

(63 reference statements)

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“…By studying patients with an inherited variant of early-onset SVD, we recently demonstrated a strategic role of SVD-related lesions 1 within frontal-subcortical neuronal circuits in determining impaired processing speed. 2,3 However, the generalizability of these findings to sporadic SVD in the elderly general population remains unexplored.…”

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confidence: 99%

Strategic white matter tracts for processing speed deficits in age-related small vessel disease

et al. 2014

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Objective: Cerebral small vessel disease is the most common cause of vascular cognitive impairment and typically manifests with slowed processing speed. We investigated the impact of lesion location on processing speed in age-related small vessel disease.Methods: A total of 584 community-dwelling elderly underwent brain MRI followed by segmentation of white matter hyperintensities. Processing speed was determined by the timed measure of the Trail Making Test part B. The impact of the location of white matter hyperintensities was assessed by voxel-based lesion-symptom mapping and graph-based statistical models on regional lesion volumes in major white matter tracts.Results: Voxel-based lesion-symptom mapping identified multiple voxel clusters where the presence of white matter hyperintensities was associated with slower performance on the Trail Making Test part B. Clusters were located bilaterally in the forceps minor and anterior thalamic radiation. Region of interestbased Bayesian network analyses on lesion volumes within major white matter tracts depicted the same tracts as direct predictors for an impaired Trail Making Test part B performance.Conclusions: Our findings highlight damage to frontal interhemispheric and thalamic projection fiber tracts harboring frontal-subcortical neuronal circuits as a predictor for processing speed performance in age-related small vessel disease. Deficits in processing speed are among the earliest and most prominent cognitive manifestations of cerebral small vessel disease (SVD). By studying patients with an inherited variant of early-onset SVD, we recently demonstrated a strategic role of SVD-related lesions 1 within frontal-subcortical neuronal circuits in determining impaired processing speed.2,3 However, the generalizability of these findings to sporadic SVD in the elderly general population remains unexplored.In the current study, we examined 584 healthy subjects from a community-dwelling cohort collected through the Austrian Stroke Prevention Study (ASPS). We focused on white matter hyperintensities (WMH) as the most common neuroimaging manifestation and on processing speed as the most prominently affected cognitive domain in SVD. Relationships between WMH and processing speed as determined by the Trail Making Test, matrix B (TMT-B) were investigated at the level of voxels, using voxel-based lesion-symptom mapping (VLSM), and at the level of regional lesion volumes within major white matter tracts, using Bayesian network analysis. We hypothesized that deficits in processing speed would be related to lesions at strategic locations.METHODS Study subjects and neuropsychology. We included 601 community-dwelling, clinically healthy subjects with neuroimaging data from the ASPS and the Austrian Stroke Prevention Family Study (ASPFS)

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Strategic white matter tracts for processing speed deficits in age-related small vessel disease

et al. 2014

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“…Before discussing described results, one should not overlook that in the newest publication by Duering et al (2013), considering neural correlates of cognitive processing speed in 235 subjects with pure vascular disease (caused by CADASIL syndrome), the authors obtain results that differ from those previously depicted. Duering and colleagues applied Trail Making Test part A and B, and the block design test, which proved to be valid methods of cognitive speed assessment (Duering et al, 2011) and MRI imaging, with distinction of two damages types: lacunar lesions and white matter hyperintensities.…”

Section: Cognitive Processing Speed Decrease As a White Matter Dysfunmentioning

confidence: 89%

Cognitive dysfunctions associated with white matter damage due to cardiovascular burden – determinants and interpretations

Krukow¹

2014

Polish Psychological Bulletin

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“…Otra posible explicación se asocia con un estudio de neuroimagen en pacientes con lesiones lacunares relacionadas con la enfermedad llamada Arteriopatía autosomal dominante con infartos subcorticales y leucoencefalopatía (CADASIL, por sus siglas en inglés) en donde se observó que los pacientes presentaron un adelgazamiento cortical del lóbulo frontal medial izquierdo, paralelo a un enlentecimiento en la velocidad de procesamiento de la información, lo cual sugiere que las lesiones subcorticales pueden provocar un daño más extenso y relacionarse con una dismunición del volumen de zonas corticales que pueden propiciar un déficit cognoscitivo mayor, afectando principalmente la función ejecutiva (Duering et al, 2013).presentaban una secuela de debilidad física no marcada pero observable por el evaluador, como consecuencia de un síndrome motor puro o sensitivo motor (n = 12 pacientes), lo cual afectó la ejecución de la copia del estímulo base de la figura compleja de Rey (FCR), provocando principalmente errores de distorsión del tipo precisión de la realización del trazo, cierre y tangencia en las unidades perceptuales. No obstante, se observó que estos pacientes presentaban un déficit en la planeación, es decir en la estrategia que siguen para la secuencia de elaboración del estímulo de la FCR.…”

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Alteraciones neuropsicológicas asociadas en pacientes con infarto lacunar.

Ledesma-Amaya

Cruz

Rodríguez-Agudelo

et al. 2014

Acta. Colomb. Psicol.

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ResumenExiste poca evidencia del deterioro cognoscitivo que defina el perfil del paciente con Infarto Lacunar (IL). El propósito de este estudio fue identificar las alteraciones neuropsicológicas en este tipo de pacientes. La muestra estuvo compuesta por 16 pacientes con IL y 16 participantes sanos con una edad promedio de 63 ± 9.41 y 64.75 ± 9.06 años y una escolaridad de 7.55 ± 4.34 y 7.94 ± 3.51, respectivamente. Se valoró la función cognoscitiva mediante un instrumento de tamizaje y una batería neuropsicológica. El análisis estadístico se llevó a cabo a través de la prueba Kruskal-Wallis y la U de Man-Whitney. Los pacientes con IL se caracterizan por la alteración de dominios como planeación, fluidez verbal, cambio atencional, habilidad visoconstructiva y velocidad de procesamiento de la información (p < 0.050). El IL se relaciona con el deterioro del funcionamiento ejecutivo y de velocidad de procesamiento, debido a la interrupción de circuitos frontocortico-subcorticales asociados con su correcto desempeño. Palabras clave: Deterioro Cognoscitivo Vascular, cápsula interna, corona radiada, tallo encefálico, infarto cerebral, neuropsicología. NEUROPSYCHOLOGICAL DISORDERS ASSOCIATED WITH PATIENTS WITH LACUNAR INFARCT AbstractThere is little evidence of cognitive impairment to define the profile of patients with Lacunar Infarction (IL). The purpose of this study was to identify the neuropsychological disorders in these patients. The sample consisted of 16 patients with IL and 16 healthy control participants with an average age of 63 ± 9.41 and 64.75 ± 9.06 years, and average schooling of 7.55 ± 4.34 and 7.94 ± 3.51, respectively. Cognitive function was assessed using a screening tool and a neuropsychological battery. Statistical analysis was carried out by the Kruskal-Wallis and Mann-Whitney U tests. Patients with IL are characterized by the alteration of domains such as planning, verbal fluency, attention switching, visoconstructive skill and information processing speed (p <0.050). The IL is related to the impairment of executive functioning and processing speed, due to the interruption of frontocortico-subcortical circuits associated with their proper performance.

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Identification of a strategic brain network underlying processing speed deficits in vascular cognitive impairment

Cited by 67 publications

References 53 publications

Strategic white matter tracts for processing speed deficits in age-related small vessel disease

Strategic white matter tracts for processing speed deficits in age-related small vessel disease

Cognitive dysfunctions associated with white matter damage due to cardiovascular burden – determinants and interpretations

Alteraciones neuropsicológicas asociadas en pacientes con infarto lacunar.

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