Identification of a sodium pump Na + /K + ATPase α1-targeted peptide for PET imaging of breast cancer

Wang, Qian; Li, Shi Bing; Zhao, Yi; Dai, Da Nian; Du, Hui; Lin, Yanwei; Ye, Jia Cong; Zhao, Jing; Xiao, Wei; Yan, Mingxia; Xiao, Yi; Liu, Shi Chu; Li, Yan; Xia, Yun; Song, Er Wei; Tang, Ge; Zhang, Wei Guang; Li, Zhi Jian; Zheng, Xiao; Cao, De Hai; Li, Man Zhi; Zhong, Qian; Chen, Zhong Ping; Qian, Chao Nan; Fan, Wei; Guo, Feng; Zeng, Mu‐Sheng

doi:10.1016/j.jconrel.2018.05.019

Cited by 26 publications

(23 citation statements)

References 37 publications

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“…As mentioned in the Introduction, the α1 and α3 subunits of NKP are frequently overexpressed in colorectal cancer, glioblastomas and breast cancer [13,14,15], and thus far, it has been the dominant view that the aberrant overexpression and activity of the NKA α1 subunit is related to the progression of various cancers, including breast cancer [17]. The expression levels of NKA α1 in nine different breast cancer cell lines have been examined, and the relative NKA α1 expression in MDA-MB-231 and SKBR-3 cells, which are known as highly metastatic breast cancer cells, was the highest among all nine tested breast cancer cells [64], even though Salyer et al [65] showed that the expression of α1, α3, and β3 was higher in MDA-MB-231 cells than in other breast cancer cells tested (T47D, MCF-7, and MDA-MB-453 cells). Further study to clarify the differential roles of α1 and α3 in breast cancer metastasis is needed, but targeting NKP-STAT-3 signaling may offer a novel therapeutic strategy to treat breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway

Trojan

Jin

et al. 2018

IJMS

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The cardiac glycosides oleandrin and odoroside A, polyphenolic monomer compounds extracted from Nerium oleander, have been found to have antitumor effects on various tumors at low doses. However, the mechanisms of anticancer effects of oleandrin and odoroside A are not well known. Therefore, in this study, we aimed to investigate the anticancer effects of oleandrin and odoroside A and their associated mechanisms in highly metastatic MDA-MB-231 breast cancer cells and radiotherapy-resistant (RT-R) MDA-MB-231 cells. Our results showed that oleandrin and odoroside A dose-dependently decreased the colony formation and the invasion of both cell lines at nanomolar ranges. Furthermore, oleandrin (50 nM) and odoroside A (100 nM) reduced octamer-binding transcription factor 3/4 (OCT3/4) and β-catenin levels and matrix metalloproteinase-9 (MMP-9) activity. Finally, we found that phospho-STAT-3 levels were increased in MDA-MB-231 and RT-R-MDA-MB-231, but not in endothelial cells (ECs), and that the levels were significantly decreased by oleandrin (50 nM) and odoroside A (100 nM). Inhibition of phospho-signal transducer and activator of transcription (STAT)-3 significantly reduced OCT3/4 and β-catenin levels and MMP-9 activity, ultimately resulting in reduced invasion. These results suggest that the anticancer effects of oleandrin and odoroside A might be due to the inhibition of invasion through of phospho-STAT-3-mediated pathways that are involved in the regulation of invasion-related molecules.

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Section: Discussionmentioning

confidence: 99%

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway

Trojan

Jin

et al. 2018

IJMS

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“…Besides the aforementioned therapeutic peptides, peptides with specific cancer cell targets are applied to bind the cancer cell targets for cancer detection and therapy (216,217). For example, a sodium pump Na + /K + ATPase α1-targeted peptide for positron emission tomography imaging of breast cancer, as peptide-based platform on dual-targeted molecular imaging, is able to more obviously visualize the disease state of a patient, leading to improved informed treatment decisions (218,219).…”

Section: Future Directionmentioning

confidence: 99%

Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application (Review)

2020

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Cancer is currently ineffectively treated using therapeutic drugs, and is also able to resist drug action, resulting in increased side effects following drug treatment. A novel therapeutic strategy against cancer cells is the use of anticancer peptides (ACPs). The physicochemical properties, amino acid composition and the addition of chemical groups on the ACP sequence influences their conformation, net charge and orientation of the secondary structure, leading to an effect on targeting specificity and ACP-cell interaction, as well as peptide penetrating capability, stability and efficacy. ACPs have been developed from both naturally occurring and modified peptides by substituting neutral or anionic amino acid residues with cationic amino acid residues, or by adding a chemical group. The modified peptides lead to an increase in the effectiveness of cancer therapy. Due to this effectiveness, ACPs have recently been improved to form drugs and vaccines, which have sequentially been evaluated in various phases of clinical trials. The development of the ACPs remains focused on generating newly modified ACPs for clinical application in order to decrease the incidence of new cancer cases and decrease the mortality rate. The present review could further facilitate the design of ACPs and increase efficacious ACP therapy in the near future.

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“…After three rounds of selection, the resulting phage pool provided a ninefold enrichment ( Figure A). The final phage pool was sequenced using high‐throughput sequencing with the methods in the literature, and we were able to identify nine abundantly conserved peptides (CEQAYQYSC, CTTHTYFGC, CQSHPGPFC, CTGPSVRTC, CLAALSNHC, CPVPGSFQC, CRWYDENAC, CREGHMGVC, and CLQNSSGSC) comprising 7.56% of the total recovered phage pool (Figure B). The phage coding the CRWYDENAC peptide (shortened to RWY) displayed the highest binding capacity of approximately tenfold over control insertless phage (Figure C), and was selected for subsequent studies.…”

Section: Resultsmentioning

confidence: 99%

Identification of an Integrin α6‐Targeted Peptide for Nasopharyngeal Carcinoma‐Specific Nanotherapeutics

Feng

Zhang

Wang

et al. 2019

Advanced Therapeutics

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Integrin α6 emerges as an attractive cancer therapeutic target. Here, the authors present for the first-time, that integrin α6 is overexpressed in nasopharyngeal carcinoma (NPC) and serves as a prognostic predictor and a cancer stem cell (CSC) biomarker. An NPC-targeted peptide CRWYDENAC (dubbed RWY) with high specificity and affinity for integrin α6 is identified, and an integrin α6-targeted nanotherapeutic against NPC is developed by encapsulating a cisplatin prodrug Pt(IV) with RWY-grafted polymeric nanoparticles (dubbed RWY-NP/Pt(IV)). The delivery of cisplatin prodrug Pt(IV) by RWY-NP/Pt(IV) results in an approximately 100-fold increase in cytotoxicity over free cisplatin, as well as a 5-fold increase over Scramble-NP/Pt(IV) control. RWY-NP/Pt(IV) suppresses NPC tumor growth with an inhibition rate of around 78%, compared with the 44% and 41% achieved by free cisplatin and Scramble-NP/Pt(IV) treatment. Loss of body weight is observed in free cisplatin treated mice but not in RWY-NP/Pt(IV)treated mice. Taken together, RWY-NP/Pt(IV) enhances the therapeutic efficacy of cisplatin treatment and reduces deleterious side effects, suggesting the potential application of the integrin α6-targeted RWY peptide for nanotherapeutics against NPC.

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Identification of a sodium pump Na + /K + ATPase α1-targeted peptide for PET imaging of breast cancer

Cited by 26 publications

References 37 publications

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway

Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application (Review)

Identification of an Integrin α6‐Targeted Peptide for Nasopharyngeal Carcinoma‐Specific Nanotherapeutics

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