Identification of a Rotavirus G12 Strain, Indonesia

The efficacy of licensed rotavirus vaccines has only been shown against certain rotavirus group A (RV-A) types. It is critical to understand the burden of rotavirus gastroenteritis (RVGE) and its prevalent types to assess the potential impact of these vaccines in Latin America and the Caribbean (LA&C). We performed a systematic review and meta-analyses of all the available evidence reported from 1990 to 2009 on the burden of rotavirus disease and strains circulating in LA&C. Eligible studies--185 country-level reports, 174 951 faecal samples--were selected from MEDLINE, Cochrane Library, EMBASE, LILACS, regional Ministries of Health, PAHO, regional proceedings, doctoral theses, reference lists of included studies and consulting experts. Arc-sine transformations and DerSimonian-Laird random-effects model were used for meta-analyses. The proportion of gastroenteritis cases due to rotavirus was 24.3% (95%CI 22.3-26.4) and the incidence of RVGE was 170 per 1000 children-years (95%CI 130-210). We estimated a global annual mortality for 22 countries of 88.2 (95%CI 79.3-97.1) deaths per 100 000 under 5 years (47 000 deaths).The most common G type detected was G1 (34.2%), followed by G9 (14.6%), and G2 (14.4%). The most common P types detected were P[8] (56.2%), P[4] (22.1%) and P[1] 5.4%, and the most prevalent P-G type associations were P[8]G1 17.9%, P[4]G2 9.1% and P[8]G9 8.8%. In the last 10 years, G9 circulation increased remarkably and G5 almost disappeared. More recently, G12 appeared and P[4]G2 re-emerged. To our knowledge, this is the first meta-analysis of rotavirus infection and burden of disease in LA&C.

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“…G12 genotype was first detected in Philippines, and appears to be spreading more rapidly in recent years [204][205][206][207][208].…”

Section: Discussionmentioning

confidence: 99%

Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta‐analysis

Linhares

Stupka

Ciapponi

et al. 2011

Reviews in Medical Virology

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“…4,22 Although the G9 genotype was only detected in 1.2% of samples, it further shows the global distribution of the G9 strains. Rotavirus G12 strains were first detected in the Philippines in 1987, 23 and in recent years they have been reported from Thailand, 24 India, 25 Indonesia, 26 Bangladesh, 27 and many other countries. In this study G12P [6] was detected in one sample, whereas G12P [8] was detected in six samples.…”

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confidence: 99%

Surveillance and Molecular Characterization of Group A Rotaviruses in Goroka, Papua New Guinea

Horwood

Luang-Suarkia²,

Bebes³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. In this study, we investigated the molecular epidemiology of group A rotaviruses in cases of acute gastroenteritis in Goroka, Papua New Guinea. From April 2008 through November 2010, 813 diarrheal stool samples were collected from children 5 years of age hospitalized with acute gastroenteritis. Rotavirus antigen was detected in 31.2% of samples using a commercial enzyme-linked immunosorbent assay. Genotyping revealed the presence of the globally circulating strains G1P[8] (50.0%), G3P[8] (23.0%), and G2P[4] (8.2%). The globally emerging strains G9 and G12 were detected in 1.2% and 6.1% of samples, respectively. Mixed infections were detected in a high proportion of samples (11.9%), with 9.0% and 3.7% of samples displaying multiple G and P genotypes, respectively.

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“…After L26, first G12 strain, was detected from the Philippines in 1987 [9], G12 strains have been found circulating several countries including Argentina [10,11], Bangladesh [12,13], Belgium [12], Brazil [14], Germany [15], Hungary [16], India [17,18], Indonesia [19], Italy [20], Japan [21], Malawi [22], Nepal [23], Paraguay [24,25], Pakistan [26], Saudi Arabia [27], Slovenia [28], South Africa [29], South Korea [30], Spain [31], Sri Lanka [32], Thailand [33], and the United States [34,35]. In these countries, only a few strains have been successfully recovered from fecal samples using cell culture systems [11,21,33,34].…”

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confidence: 99%

Complete genomic characterization of cell culture adapted human G12P[6] rotaviruses isolated from South Korea

Than

Lim

et al. 2011

Virus Genes

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Two unusual human rotavirus G12 strains, CAU195 and CAU214, were isolated from female pediatric diarrhea patients under 12 months of age in 2006 using a cell culture system and their full genome sequences were analyzed. The 11 gene segments of both Korean G12 strains were classified as G12-P[6]-R1-C1-M1-I1-A1-N1-T1-E1-H1 genotypes. Notably, the Korean strains were of the same genotypes as previously reported strains isolated from Bangladesh in 2003 (Dhaka12-03), from the United States in 2005-2006 (US6597), and from Germany in 2008 (GER126-08 and GER172-08), suggesting that closely related G12P[6] strains are persistent and widespread.

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Identification of a Rotavirus G12 Strain, Indonesia

Cited by 11 publications

References 10 publications

Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta‐analysis

Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta‐analysis

Surveillance and Molecular Characterization of Group A Rotaviruses in Goroka, Papua New Guinea

Complete genomic characterization of cell culture adapted human G12P[6] rotaviruses isolated from South Korea

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