Identification of a novel surface mutant of hepatitis B virus in a seronegative chronic liver disease patient

Banerjee, Kakoli; Guptan, R. C.; Bisht, Rachna; Sarin, S.K.; Khandekar, Pramod

doi:10.1016/s0168-1702(99)00106-9

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…In addition, a sT118A HBsAg mutation was identified in patient 6 both pre‐ and post‐transplant. The sT118A mutation has been predicted to have a destabilizing effect on structural integrity of the ‘a’ determinant and also to alter the antigenicity profile of the mutant HBsAg in an HBsAg‐seronegative chronic liver disease patient (48). All group II patients had at least one documented anti‐HBsAg level of <200 IU/mL while receiving HBIG and prior to the date of the post‐transplant specimen analyzed.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Hepatitis B Virus Surface Antigen and Polymerase Mutations in Liver Transplant Recipients Pre- and Post-Transplant

Germer

Charlton

Ishitani

et al. 2003

American Journal of Transplantation

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We evaluated serum samples from 18 chronic hepatitis B virus (HBV) patients who underwent liver transplantation for the presence of HBV polymerase and S gene mutations and HBV genotype using a new commercially available sequencing assay. All three patients with hepatitis B immune globulin (HBIG) treatment failure followed by nucleoside analogue treatment failure were infected with HBV genotype C; a pre-existing HBV S antigen (HBsAg) mutation (sD144A) was identified in one patient pretransplant, while sG145R mutations emerged in the other two patients post-transplant. These HBsAg mutations persisted for the duration of the study (5-6 years), despite the absence of HBIG administration for a 4-5-year period. Significant viral polymerase mutations (rtL180M and rtM204I/V) also emerged in all of these patients following treatment with lamivudine and/or famciclovir. Four of six patients with HBIG breakthrough without nucleoside analogue treatment failure yielded potentially significant HBsAg mutations post transplant. These data do not support previous reports highlighting the disappearance of HBsAg mutants in liver transplant recipients after discontinuation of HBIG. Determination of HBV genotype, as well as identification of HBV polymerase and S gene mutations in liver transplant candidates may be warranted to optimize HBV management strategies post transplant.

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Section: Resultsmentioning

confidence: 99%

Characterization of Hepatitis B Virus Surface Antigen and Polymerase Mutations in Liver Transplant Recipients Pre- and Post-Transplant

Germer

Charlton

Ishitani

et al. 2003

American Journal of Transplantation

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“…There are several reports on HBsAg negative virus carriers (HBV-DNA positive) with immunosilent infection or "unusual serologic constellation, these include (Carman et al, 1990;Brechot et al, 1991;Banerjee et al, 1999;Carman, 1996Carman, , 1997Grethe et al, 1998;Koyanagi et al, 2000):…”

Section: Hbv Mutants and Diagnostic Assaysmentioning

confidence: 99%

Genetic variability of the S gene of hepatitis B virus: clinical and diagnostic impact

Weber

2005

Journal of Clinical Virology

184

136

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“…Occult HBV infected subjects have a low level of viremia and low viral replication. Occult HBV infection in the general healthy population has been reported to be among 9–16% 7 . HBsAg negative HBV DNA positive status in patients with HBV‐related chronic liver disease was reported in nearly 10.8% of patients 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Occult HBV infection in the general healthy population has been reported to be among 9-16%. 7 HBsAg negative HBV DNA positive status in patients with HBV-related chronic liver disease was reported in nearly 10.8% of patients. 8 The same observation has been confirmed in other reports from India.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection

Kumar¹,

Kazim²,

Kumar³

et al. 2009

J of Gastro and Hepatol

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Identification of a novel surface mutant of hepatitis B virus in a seronegative chronic liver disease patient

Cited by 16 publications

References 27 publications

Characterization of Hepatitis B Virus Surface Antigen and Polymerase Mutations in Liver Transplant Recipients Pre- and Post-Transplant

Characterization of Hepatitis B Virus Surface Antigen and Polymerase Mutations in Liver Transplant Recipients Pre- and Post-Transplant

Genetic variability of the S gene of hepatitis B virus: clinical and diagnostic impact

Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection

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