Identification of a Novel Serum Proteomic Signature for Primary Sjögren’s Syndrome

Padern, Guillaume; Ferreira, Rosanna; Assou, Saïd; Guilpain, Philippe; Maria, A.; Goulabchand, Radjiv; Galéa, Pascale; Jurtela, Maja; Jørgensen, Christian; Pers, Yves‐Marie

doi:10.3389/fimmu.2021.631539

Cited by 10 publications

(4 citation statements)

References 72 publications

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“…Using a second cohort of pSS patients, five proteins including CXCL13, TNF-receptor 2, CD48, B-cell activating factor (BAFF), and PD-L2 (Programmed cell death ligand 2) were validated as pSS-associated biomarkers. Another study investigated which serum protein biomarkers, measured by Bio-Plex, could distinguish pSS from other autoimmune diseases, such as SLE and RA [ 36 ]. Out of 63 proteins, they were able to identify eight and four proteins that could differentiate pSS from SLE and RA, respectively.…”

Section: Resultsmentioning

confidence: 99%

Multi-Omic Biomarkers for Patient Stratification in Sjogren’s Syndrome—A Review of the Literature

et al. 2022

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Sjögren’s syndrome (SS) is a heterogeneous autoimmune rheumatic disease (ARD) characterised by dryness due to the chronic lymphocytic infiltration of the exocrine glands. Patients can also present other extra glandular manifestations, such as arthritis, anaemia and fatigue or various types of organ involvement. Due to its heterogenicity, along with the lack of effective treatments, the diagnosis and management of this disease is challenging. The objective of this review is to summarize recent multi-omic publications aiming to identify biomarkers in tears, saliva and peripheral blood from SS patients that could be relevant for their better stratification aiming at improved treatment selection and hopefully better outcomes. We highlight the relevance of pro-inflammatory cytokines and interferon (IFN) as biomarkers identified in higher concentrations in serum, saliva and tears. Transcriptomic studies confirmed the upregulation of IFN and interleukin signalling in patients with SS, whereas immunophenotyping studies have shown dysregulation in the immune cell population frequencies, specifically CD4+and C8+T activated cells, and their correlations with clinical parameters, such as disease activity scores. Lastly, we discussed emerging findings derived from different omic technologies which can provide integrated knowledge about SS pathogenesis and facilitate personalised medicine approaches leading to better patient outcomes in the future.

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Section: Resultsmentioning

confidence: 99%

Multi-Omic Biomarkers for Patient Stratification in Sjogren’s Syndrome—A Review of the Literature

et al. 2022

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“…Generally, SLE, RA, and pSS are common rheumatic disorders with the involvement of the immune system. 10 They are different in prevalence, pathology, and clinical manifestations, but they all may evolve in a condition of chronicity, often causing a disability for exocrinopathy in lacrimal glands and inducing ocular surface discomfort. There is a well-known association of dry eye with rheumatic disease severity like pSS, RA, and SLE.…”

Section: Discussionmentioning

confidence: 99%

Elevated Rheumatoid Factor Associates with Dry Eye in Patients with Common Autoimmune Diseases

Zhao¹,

Xiao²,

Zhang³

et al. 2022

JIR

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Purpose To investigate the association and application value of rheumatoid factor (RF) in diagnosis of dry eye among patients with common autoimmune diseases. Patients and Methods A retrospective case-control study was conducted from Jan 1st 2019 to Dec 31st 2020, and 117 patients with common autoimmune diseases were enrolled. The concentrations of serum RF were detected. The receiver operating characteristics (ROC) curve was plotted to evaluate the values of RF in diagnosis. Results Compared with no dry eye patients, patients with dry eye (n = 59, 50.43%) had higher levels of RF ( P < 0.001). Moreover, Pearson’s correlation analysis showed that RF levels were negatively correlated with Schirmer-I tear test ( P = 0.004) and invasive tear film break-up time ( P = 0.002), respectively. The statistically significant threshold value (cut-off points) of the RF levels for dry eye was 21.4 (IU/mL), and the areas under the curve (AUC) of RF was 0.73 (95% confidence interval [CI]: 0.639–0.821; P < 0.001) (sensitivity = 78%; specificity = 58.6%) for dry eye among patients with common autoimmune diseases. Conclusion Serum levels of RF may be an independent factor for dry eye among patients with common autoimmune diseases, and they may have a high significant value and clinical application value.

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“…However, IL-17 in itself, just like TNFa, is not specific to SSDE as it is found in Fractalkine/CX3CL1, which is a chemokine involved specifically in chemotactic activity on monocytes and T-lymphocytes and the extravasation of leukocytes towards the inflammation site. The I-TAC/CXCL11 is an IFN-gamma-inducible chemokine, whose role is to attract activated T-lymphocytes, natural killer cells, and macrophages to the inflammation site [ 94 ].…”

Section: Current Diagnostic Challenges Encountered By Cliniciansmentioning

confidence: 99%

An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding

Kulbay

Tănăsescu

et al. 2023

IJMS

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Sjögren’s syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren’s syndrome dry eye (SSDE) from non-Sjögren’s syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. The purpose of this article is to describe the current molecular understanding of Sjögren’s syndrome and its implications for novel diagnostic modalities on the horizon. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. The SSDE pathophysiology and immunology pathways have become better understood in recent years. Novel diagnostic modalities, such as tear and saliva proteomics as well as exosomal biomarkers, provide hope on the horizon.

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Identification of a Novel Serum Proteomic Signature for Primary Sjögren’s Syndrome

Cited by 10 publications

References 72 publications

Multi-Omic Biomarkers for Patient Stratification in Sjogren’s Syndrome—A Review of the Literature

Multi-Omic Biomarkers for Patient Stratification in Sjogren’s Syndrome—A Review of the Literature

Elevated Rheumatoid Factor Associates with Dry Eye in Patients with Common Autoimmune Diseases

An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding

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