Perovskite photodetectors have gradually shown preeminent photoelectric performance due to the unique material properties. In recent years, lots of works have been reported in improving the sensitivity, changing detection spectrum range and enhancing long‐term stability. Herein, we summarize the some efficient strategies for performance improvement and synchronously analyze severe issues exposed in that. Furthermore, some reasonable proposals are put forward to solve future predicted troubles. In addition, more prospective assumptions are proposed on the basis of the development trend in photoelectric detection fields. We hope this perspective will allow researchers to have a clearer understanding of recent studies based on perovskite photodetectors and inspire more meaningful work in the future.

the representative of the third-generation photovoltaics, have attracted great attention owing to unique properties such as light weight, flexibility, low cost, and low-temperature solution process. PCE of OSCs has been greatly improved via continuous development of novel semiconducting materials and performance optimization in the past two decades. [3][4][5] Lead halide perovskites, as star semiconducting materials, have obtained enormous attention in optoelectronic fields due to their outstanding properties, such as, tunable band gaps, high absorption coefficient, high charge carrier mobility, and long carrier diffusion lengths. [6][7][8][9][10][11] Until 2021, PCEs of perovskite/silicon tandem cells and OSCs have exceeded 29% and 18%, respectively. [12][13][14] However, the high-efficiency cells are usually prepared by spin-coating, with an active area of less than 0.1 cm 2 . There is no doubt that the development of OSCs and PSCs will go to large-scale industrial production, thus the challenge is achieving large-area uniform active layers. However, due to the uneven centrifugal force in the traditional spin-coating process, the thicknesses at the center and the edge of the substrate is different, especially for large-area films. The thick area shows increased nonradiative recombination loss. The thin area shows reduced lightharvesting ability and increased pinholes, leading to reduced efficiency. To address these issues, developing large-area coating methods is an effective way. [15] So far, various methods have been applied to large-area film fabrication, including spray coating, [16][17][18][19] dip coating, [20,21] slot-die coating, [22,23] and bladecoating. Among these techniques, blade-coating has achieved the greatest success, with the best PCE of ≈22%.In this review, we summarize the recent advances of bladecoating techniques for fabricating large-area PSCs and OSCs, and analyze the issues that need to be solved in blade-coating technology. We hope it can provide new strategies for the commercialization of the third-generation solar cells. Blade-Coating TechnologyBlade-coating is a widely recognized method for the preparation of large-area films. Blade-coating method, with the merits of efficient material utilization, in situ crystallization and adjustable parameters, has been investigated in depth for the preparation of various thin films. [15] Figure 1 demonstrates the High-efficiency perovskite solar cells (PSCs) and organic solar cells (OSCs) are promising alternatives for silicon-based solar cells. At present, the key point for commercialization of PSCs and OSCs is realizing large-scale production while maintaining the same high efficiency as small-area ones. In this review, the blade-coating method for preparing large-area films is introduced first and the recent advances of blade-coated OSCs and PSCs are summarized. Then, the effects of blading parameters on the crystal growth and film formation of the light-harvesting materials are discussed. Moreover, the limitations and advantages of making h...

Osteoarthritis (OA) is a common joint disease in the elderly population. Its development has been reported to be associated with cartilage degradation and inflammatory responses. Schisandrin A, a bioactive lignin in Schisandra sphenanthera, has shown its anti-inflammatory potential in various inflammation diseases. However, the effects of Schisandrin A on OA remain to explore. In this study, rat chondrocytes were treated with IL-1β (10 ng/ml) with or without different concentrations of Schisandrin A for 24 h. Cell viability was evaluated by CCK-8 assay. Production of nitric oxide (NO) and prostaglandin E2 (PGE2) was measured by the Griess reaction and ELISA. The MAPK/NF-κB-related signaling molecules expression and the protein production of inducible nitric oxide synthase (iNOS), cyclooxygenase (Cox)-2, MMPs (MMP1, MMP3, MMP13), ADAMTS5, Collagen II, aggrecan, and Sox9 were detected by Western blot. Protein expression of Collagen II, aggrecan, and p65 nuclear translocation was evaluated by immunofluorescence. In vivo, intra-articular injection of 50 μM Schisandrin A or equal volume of vehicle was performed on rat OA models. Severity of cartilage damage was evaluated by HE and Safranin-O-Fast green staining. Our results revealed that Schisandrin A could suppress the IL-1β-induced production of NO and PGE2 in rat chondrocytes. Consistent with these findings, the upregulation of iNOS and Cox2 could also been decreased by Schisandrin A. Additionally, Schisandrin A could inhibit IL-1β-induced cartilage matrix catabolic enzymes including MMPs and ADAMTS5. Moreover, the IL-1β-induced downregulation of Collagen II, aggrecan, and Sox9 could be ameliorated by Schisandrin A. Mechanistically, Schisandrin A functioned by suppressing MAPK and NF-κB signal pathways. In vivo, Schisandrin A prevented cartilage damage in rat OA model. In conclusion, this study elucidates that Schisandrin A inhibits the IL-1β-induced inflammation and cartilage degradation via suppression of MAPK and NF-κB signal pathways, indicating its potential role in OA therapy.

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