Identification of a novel HLA‐DRB1*14 allele, HLA‐DRB1*14:150, in a Chinese individual

Abstract

HLA-DRB1*14:150 shows one nucleotide difference when compared with DRB1*14:54:01 at codon 49 (A > P).

The HLA‐DRB1*04:357 allele first identified in a Chinese transplant recipient

“…Informed consent was obtained from the recipient. HLA typing and the Group Specific Sequencing confirming the proband for the HLA‐DRB1 gene were performed using SeCore® Sequencing Kits (Life Technologies™, Brown Deer, WI) according to our previous report 4 . HLA‐DRB1 genotyping for the proband was also performed by next‐generation sequencing (NGS), with the same results as the SBT typing.…”

“…HLA typing and the Group Specific Sequencing confirming the proband for the HLA-DRB1 gene were performed using SeCore ® Sequencing Kits (Life Tech-nologies™, Brown Deer, WI) according to our previous report. 4 HLA-DRB1 genotyping for the proband was also performed by next-generation sequencing (NGS), with the same results as the SBT typing. The sequencing results showed HLA-DR alleles of the proband as HLA-DRB1*16:02 and a novel allele, now officially named HLA-DRB1*04:357.…”