Identification of a new coeliac disease subgroup: antiendomysial and anti‐transglutaminase antibodies of IgG class in the absence of selective IgA deficiency

Picarelli, Antonio; Tola, Marco Di; Sabbatella, L.; Mastracchio, Antonio; Trecca, Antonello; Gabrielli, Fabiola; Cello, T. Di; Anania, M.C.; Torsoli, A

doi:10.1046/j.1365-2796.2001.00793.x

Cited by 55 publications

(35 citation statements)

References 23 publications

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“…Our result agree with other [12].. At the mucosal level, IL-10 cytokine favor the generation of IgA [13; 14]. Beside the fact that IL-10 has immunostimulatory effect on B-cells [15].…”

Section: Correlation Between Iga -Ttg Iga -Ema and Cytokinessupporting

confidence: 92%

Assessment of Inerferon Gamma (Ifn-Γ ) & Interleukin-10 (Il-10) in Patients Afflected with Celiac Disease

Elia¹,

Hussain²

2017

Cihan Univ.-Erbil Sci. J.

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Celiac disease (CD) is an immune mediated malabsorption syndrome that occur in genetically susceptible individuals intolerant to dietary gluten. Although considered as a primary gastrointestinal disease, CD is now known to have widespread systemic manifestation.We attempted to define the nature and role of some systemic cytokine that possibly play a role in the pathophysiology of the disease.The sera were collected from those patient suspected of having CD on clinical ground (Newly diagnosed) & then subjected to serologic tests namely anti -tissue transglutaminase IgA, IgG (tTG) & IgA, IgG -Endomysial antibody (EMA).The positive sera for anti -tTG IgA and IgA EMA autoantibody above the cutoff level were then subjected to cytokines assessment namely serum interferon gamma (IFN-γ) and interleukin-10 (IL -10) level.The participant groups comprised 50 newly diagnosed (ND) CD, 20 patients on gluten free diet (GFD) and 20 apparently healthy CD free control (These groups were subjected to the above parameters).The results of the present study among the newly diagnosed cases reveals antitTG IgA and IgA -EMA seropositivity in 15.1 % of the total 330 sera examined ;with anti-tTG IgG & IgG -EMA seronegativity (below the cut-off ) in all sera tested. The highest percent distribution of anti-tTG IgA and IgA -EMA seropositivity was at the serum concentration of 20-29 (36 % & 34 % respectively).A significant decrease (P˂ 0.01) was observed in the mean concentration of antitTG IgA and IgA-EMA between newly diagnosed CD and patients on GFD. The mean

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“…Our result agree with other [12].. At the mucosal level, IL-10 cytokine favor the generation of IgA [13; 14]. Beside the fact that IL-10 has immunostimulatory effect on B-cells [15].…”

Section: Correlation Between Iga -Ttg Iga -Ema and Cytokinessupporting

confidence: 92%

Assessment of Inerferon Gamma (Ifn-Γ ) & Interleukin-10 (Il-10) in Patients Afflected with Celiac Disease

Elia¹,

Hussain²

2017

Cihan Univ.-Erbil Sci. J.

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show abstract

“…At the mucosal level, cytokines favor the generation of IgA-producing plasma cells [54,55]. Although the degree of inflammation or systemic involvement cannot be estimated by assays performed at a given time point, our findings suggest roles for certain cytokines in eliciting or sustaining the humoral response in CD, with the exception of IFN-␥ and TNF-␣.…”

Section: Discussionmentioning

confidence: 76%

Serum cytokine elevations in celiac disease: Association with disease presentation

Manavalan¹,

Hernandez²,

Shah³

et al. 2010

Human Immunology

120

108

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“…New types of assays for tTG Ab measurement developed using this inhibition principle would have the advantage that both IgA and/or IgG tTG Ab could be easily detected in one assay [16,24,[41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Epitopes recognised by tissue transglutaminase antibodies in coeliac disease

Nakachi

Powell

Swift

et al. 2004

Journal of Autoimmunity

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Identification of a new coeliac disease subgroup: antiendomysial and anti‐transglutaminase antibodies of IgG class in the absence of selective IgA deficiency

Cited by 55 publications

References 23 publications

Assessment of Inerferon Gamma (Ifn-Γ ) & Interleukin-10 (Il-10) in Patients Afflected with Celiac Disease

Assessment of Inerferon Gamma (Ifn-Γ ) & Interleukin-10 (Il-10) in Patients Afflected with Celiac Disease

Serum cytokine elevations in celiac disease: Association with disease presentation

Epitopes recognised by tissue transglutaminase antibodies in coeliac disease

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