Identification of a flavonoid C -glycoside as potent antioxidant

Wen, Li; Zhao, Yupeng; Jiang, Yueming; Yu, Limei; Zeng, Xiaofang; Yang, Jiali; Tian, Miaomiao; Liu, Huiling; Yang, Bao

doi:10.1016/j.freeradbiomed.2017.05.027

Cited by 79 publications

(43 citation statements)

References 40 publications

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“…Above all, the FRAP method confirmed the reducing power of LAMIC (211.34 ± 15.92 mmol EAA/g) using Ascorbic acid as standard. This reducing power could be attributed to the presence of polyphenolic compounds in LAMIC extract, which are known to have antioxidant activity by their ability to capture free radicals and metal complexation [25][26][27] . The present results are in line with a previous study, which showed that the fruits of Lannea microcarpa have a good antioxidant activity that was correlated with the content in polyphenolic compounds and flavonoids 4 .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant properties and subchronic toxicity of the standardized extract of LAMIC, a phytomedicine prototype based on aqueous extracts from trunk bark of Lannea microcarpa Engl and K. Krause

Belemnaba¹,

Soubeiga²,

Ouédraogo³

et al. 2019

J. Drug Delivery Ther.

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Aims: This study investigated the antioxidant activity and the 90 days subchronic toxicity of the standardized LAMIC phytomedicine prototype based on aqueous extracts from Lannea microcarpa trunk bark. Methods: Three spectrophotometric methods were used to evaluated the antioxidant activity of LAMIC which were 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical, 2,2’-azinobis(3-ethylbenzolin-6-sulphonate) (ABTS) radical scavenging assays and ferric reducing antioxidant power (FRAP) assays. For the standardized LAMIC subchronic toxicity study, male and female Wistar rats were used by daily oral administration at doses of 500, 1000 and 1500 mg/kg bw consecutively for 90 days. Results: The LAMIC extract exhibit better inhibitory activity against DPPH radical than ABTS radical with respective IC50 values of 45.38±3.21 µg/mL and 66.45±18.76 µg/mL, while FRAP assay exhibit antioxidant activity of 211.34±15.92 mmol EAA/g. Subchronic oral administration of LAMIC was well-tolerated at all tested doses. No behavioral and physiological changes and mortality were observed. The LAMIC extract did not present any impact on general hematological parameters and biochemical parameters. Moreover, no significant changes were raised in organ and body weight of treated groups compared to the Control group. Conclusion: These results support that LAMIC prototype was a valuable source of natural antioxidants and no toxicity was associated to its long terms oral consumption in rats indicating a potential application as a cardiovascular protective formulation. Keywords: LAMIC–Lannea microcarpa–Standardization–Antioxidant–Subchronic toxicity.

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Section: Discussionmentioning

confidence: 99%

Antioxidant properties and subchronic toxicity of the standardized extract of LAMIC, a phytomedicine prototype based on aqueous extracts from trunk bark of Lannea microcarpa Engl and K. Krause

Belemnaba¹,

Soubeiga²,

Ouédraogo³

et al. 2019

J. Drug Delivery Ther.

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“…Flavonoids generally refer to a series of bioactive compounds formed by the connection of two benzene rings with phenolic hydroxyl groups (A and B rings) through the central three carbon atoms. They have the effects of anti-inflammation, antioxidation, scavenging free radicals and so on (Wen et al, 2017). The bioactive compounds of flavonoids for protecting effect on bone by acting on osteoclasts or osteoblasts include kaempferol (KP), quercetin, icariin, poncirin, baicalin, silibinin, etc.…”

Section: Flavonoidsmentioning

confidence: 99%

Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis

et al. 2020

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Bone destruction is an important pathological feature of rheumatoid arthritis (RA), which finally leads to the serious decline of life quality in RA patients. Bone metabolism imbalance is the principal factor of bone destruction in RA, which is manifested by excessive osteoclast-mediated bone resorption and inadequate osteoblast-mediated bone formation. Although current drugs alleviate the process of bone destruction to a certain extent, there are still many deficiencies. Recent studies have shown that traditional Chinese medicine (TCM) could effectively suppress bone destruction of RA. Some bioactive compounds from TCM have shown good effect on inhibiting osteoclast differentiation and promoting osteoblast proliferation. This article reviews the research progress of bioactive compounds exacted from TCM in inhibiting bone destruction of RA, so as to provide references for further clinical and scientific research.

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“…Aktivitas antioksidan dari ekstrak metanol yang mengandung 1% HCl dari sabut kelapa hijau ini disebabkan oleh senyawa flavonoid yang terdeteksi. Flavonoid merupakan senyawa yang erat kaitannya sebagai zat yang mempunyai kapasitas antioksidan bagi tubuh (Astuti, 2008;Permana et al, 2016;Wen et al, 2017). Antosianin yang terdeteksi dalam ekstrak metanol yang mengandung 1% HCl dari sabut kelapa hijau kemungkinan besar juga menyumbangkan aktivitas antioksidan.…”

Section: Aktivitas Antioksidanunclassified

Identification of Phytochemical and Characterization of Anthocyanin Green Coconut Fiber (Cocos nucifera L var varidis)

Anggriani

Ain

Adnan

et al. 2017

JTP

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Penelitian ini bertujuan untuk mengidentifikasi senyawa fitokimia dan mengarakterisasi antosianin pada sabut kelapa hijau. Hasil uji fitokimia menunjukkan bahwa ekstrak kasar metanol yang mengandung HCl 1% dari sabut kelapa hijau mengandung antosianin sebagai salah satu flavonoid dengan kandungan 8.34 mg/100 g berat basah. Hasil LC/MS menyatakan bahwa terdapat 4 jenis antosianin didalamnya yakni Cyanidin-3-O-glucoside, Peonidin-3-O-glucoside, Cyanidin-3-O-(6"-O-coumaroyl)-glucoside, Petunidin-3-O-glucoside. Hasil ini menunjukkan bahwa sabut kelapa hijau dapat berpotensi sebagai sumber pigmen antosianin alami

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Identification of a flavonoid C -glycoside as potent antioxidant

Cited by 79 publications

References 40 publications

Antioxidant properties and subchronic toxicity of the standardized extract of LAMIC, a phytomedicine prototype based on aqueous extracts from trunk bark of Lannea microcarpa Engl and K. Krause

Antioxidant properties and subchronic toxicity of the standardized extract of LAMIC, a phytomedicine prototype based on aqueous extracts from trunk bark of Lannea microcarpa Engl and K. Krause

Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis

Identification of Phytochemical and Characterization of Anthocyanin Green Coconut Fiber (Cocos nucifera L var varidis)

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