Identification and Quantitation of Phenolic Compounds from the Seed and Pomace of <i>Perilla frutescens</i>
 Using HPLC/PDA and HPLC-ESI/QTOF/MS/MS

Zheng, Guoqiang; Li, Sicong; Lin, Zongtao; Yang, Ruinan; Zhao, Yan; Liu, Jinchuan; Yang, Shi‐Yao; Chen, Ailiang

doi:10.1002/pca.2521

Cited by 37 publications

(26 citation statements)

References 27 publications

(49 reference statements)

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“…[47], fennel [48], Perilla frutescens Mill. [49] as well as Lamiaceae taxa [50]. There are reports indicating that rosmarinic acid suppresses the glycolytic ATP production under aerobic conditions which is known as the Warburg effect, a universal property of most cancer cells [51].…”

Section: Resultsmentioning

confidence: 99%

Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS

et al. 2017

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Continuing our work on the sources of natural bioactive compounds, we evaluated the antimicrobial and antioxidant activities of Nepeta trachonitica as well as its major phenolic content using the high-performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) technique. For antioxidant activity, ferric reducing antioxidant power (FRAP) and cupric ion reducing antioxidant capacity (CUPRAC) methods were performed to measure the reducing power and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was employed to evaluate the radical scavenging activity of the sample. For antimicrobial activity, three Gram-positive and four Gram-negative microbial species as well as three fungi species were tested. N. trachonitica appeared to have reasonable antioxidant activity and decent antimicrobial activity as indicated by the inhibition of the organisms’ growth. The most susceptible species were Bacillus subtilis ATCC 6633 and Escherichia coli ATCC 11229 among the organisms tested. Ethanol extract of the plant has the highest effect on Saccharomyces cerevisiae but no effect on Yarrowia lipolytica. The HPLC-MS/MS analysis showed that at least 11 major phenolic compounds of N. trachonitica exist, the major ones being rosmarinic acid, chlorogenic acid and quinic acid. The obtained results suggest that N. trachonitica could be a promising source for food and nutraceutical industries because of its antimicrobial and antioxidant properties and phenolic compounds.

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Section: Resultsmentioning

confidence: 99%

Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS

et al. 2017

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“…In recent years, the use of bio‐waste as a raw material both in scientific and industrial areas has gained huge interest. Agro‐food waste is often high in valuable compounds such as bioactive molecules useful in the preparation of dietary supplements and pharmaceuticals products …”

Section: Introductionmentioning

confidence: 99%

“…Agro-food waste is often high in valuable compounds such as bioactive molecules useful in the preparation of dietary supplements and pharmaceuticals products. [1][2][3] Sweet cherry (Prunus avium L.) is one of the most popular springsummer fruits, characterised by attractive appearance, firmness, high nutritional value and delicious taste. Sweet cherries are known as a good source of natural bioactive compounds with beneficial health effect.…”

Section: Introductionmentioning

confidence: 99%

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

Nastić

Lozano-Sánchez²,

Borrás-Linares³

et al. 2019

Phytochemical Analysis

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Introduction In recent years, an increasing interest in biological properties of sweet cherry (Prunus avium L.) stems has resulted in increased attention for advanced extraction techniques and their optimisation. Objectives In the present study chemical profiles of P. avium stems extracts obtained by selected emerging technologies, such as pressurised liquid extraction (PLE) and supercritical fluid extraction (SFE), under different experimental conditions were compared. Material and Methods All SFEs were carried out at 40°C in a dynamic mode with different solvent combinations (CO2 plus ethanol at 7 and 15%) and pressures (150 and 300 bar). The PLE experiments were performed in a static mode for all tested combinations of extraction solvent (ethanol–water from 0% to 100%) at temperatures ranging from 40 to 200°C. A complete analytical characterisation of cherry stem extracts was performed by high‐performance liquid chromatography coupled to electrospray ionisation quadrupole time‐of‐flight mass spectrometry (HPLC‐ESI‐QTOF‐MS). Results PLE showed to be more efficient than SFE removing a wide variety of compounds with different polarities being phenols the most abundant, whereas SFE resulted in a higher amount of fatty acids and derivatives. Chemical characterisation of the extracts was carried out by HPLC‐ESI‐QTOF‐MS yielding in total 42 identified compounds, among which 22 compounds were identified in P. avium stems for the first time. Conclusion These results point out the possibility of sweet cherry stem extracts to be incorporated in formulations manufactured by food and pharmaceutical industry. Also, these new thermal and high‐pressure industrial technologies proved to be promising candidates in the valorisation of sweet cherry by‐product.

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“…Perilla seed contains approximately 35–45 % oil, which is a good source of ω3 polyunsaturated fatty acid, particularly α‐linolenic acid at approximately 54–65 % of total fatty acids (Asif, ). In addition, perilla contains phenolic compounds including caffeic acid, rosmarinic acid, apigenin, luteolin, and chrysoeriol and their glycosides, which are associated with antioxidant activity (Guan et al, ; Lee et al, ).…”

Section: Introductionmentioning

confidence: 99%

A chemically characterized ethanolic extract of Thai Perilla frutescens (L.) Britton fruits (nutlets) reduces oxidative stress and lipid peroxidation in human hepatoma (HuH7) cells

Paradee

Howes

Utama‐ang

et al. 2019

Phytotherapy Research

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A chemically characterized ethanolic extract of Thai Perilla frutescens (L.) Britton fruits (nutlets) reduces oxidative stress and lipid peroxidation in human hepatoma (HuH7) cells Perilla frutescens is cultivated in East Asian countries including Thailand, and the nutlets (single-seeded fruits) are used as traditional and medicinal food. Perilla nutlets extracted by ethyl acetate (EA), 80% ethanol (Eth), and hot water (HW) sequentially were chemically characterized using high-resolution accurate liquid chromatography-mass spectrometry with the main compounds detected assigned as rosmarinic acid and derivatives of the flavones apigenin and luteolin, with the more diverse chemical composition observed with the Eth extract. All extracts showed dose-dependent free-radical scavenging activity, with the Eth extract the most potent (IC 50 = 3.43 mg/ml for ABTS • scavenging and 0.27 mg/ml for DPPH • scavenging). The Eth extract also inhibited AAPH-induced hemolysis (IC 50 = 0.07 mg/ml) more potently than did the HW (IC 50 = 0.38 mg/ml) and EA extracts (IC 50 = 1.63 mg/ml). An MTT test revealed all the extracts were noncytotoxic at concentrations up to 200 μg/ml. Only the Eth and EA extracts showed protective effects against the generation of reactive oxygen species and lipid peroxidation in FeCl 3 -induced HuH7 cells in a dose-dependent manner. Our findings suggest the Eth extract of Thai perilla nutlets, containing rosmarinic acid and flavones and their derivatives, may have potential to provide protection against oxidative stress in hepatic disorders.

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Identification and Quantitation of Phenolic Compounds from the Seed and Pomace of Perilla frutescens Using HPLC/PDA and HPLC-ESI/QTOF/MS/MS

Abstract: The results indicated perilla pomace is a promising alternative source of phenolic compounds that could be recovered and potentially used as natural anti-oxidants.

Cited by 37 publications

References 27 publications

Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS

Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

A chemically characterized ethanolic extract of Thai Perilla frutescens (L.) Britton fruits (nutlets) reduces oxidative stress and lipid peroxidation in human hepatoma (HuH7) cells

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