Identification and quantification of polyphenol phytoestrogens in foods and human biological fluids

Wilkinson, A. W.; Wähälä, Kristiina; Williamson, Gary

doi:10.1016/s1570-0232(02)00095-8

Cited by 73 publications

(36 citation statements)

References 84 publications

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“…Phytoestrogens are plant derived polyphenolic compounds, which are widely used for treatment and protection against various health problems, including bone diseases (Wilkinson et al 2002;Hassan et al 2013). Phytoestrogens are thought to protect from bone loss mainly through estrogen dependent mechanisms as phytoestrogens seemed to directly increase estrogen levels, as seen in the present study and in other investigations (Rice and Whitehead 2008).…”

Section: Discussionsupporting

confidence: 72%

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

2013

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The purpose of the present study was to investigate the osteoprotective effects of soybean oil (SbO) and sesame oil (SO) in ovarictomized (OVX) rats. The results indicated that the OVX rats exhibited a significant decrease in Ca and P level in both serum and bone, the activities of the antioxidant enzymes SOD and CAT and the antioxidant biomarker GSH accompanied with a marked increase in the oxidative stress markers MDA and PC, the inflammatory indices (TNF-a, CRP levels, WBCs counts and ACP activity) in, both, bone and serum. Supplementating the diet of the OVX rats with SbO (15 % w/w) or SO (10 % w/w) for 2 months to resulted in modulation of the alterations in all tested parameters and succeeded to restore minerals, antioxidant enzymes, antioxidant biomarkers, oxidative stress markers, inflammatory indices, and WBCs counts. It could be concluded that the consumption of diets supplemented with SbO or SO might be useful for preventing bone loss caused by estrogen deficiency in ovariectomy status.

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Section: Discussionsupporting

confidence: 72%

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

2013

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“…Although the range of detection limits contain a wide variety between laboratories, generally reported sensitivity of analytics methods is as follows: immunoassay >HPLC-MS=HPLC-multichannel electrochemical detection (coularray)>GC-single ion monitoring-mass spectrometry>HPLC-UV diode array>HPLC-single channel electrochemical detection (Wilkinson et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The HPLC-UV (or DAD) method is proper when high levels of isoflavones are presented in biospcimens . The detection limit of this method is too high for the measurement of isoflavonoids in non-supplemented samples or in food products not containing large amounts of isoflavonoids (Wilkinson et al, 2002). HPLC-UV (or DAD) methods are less sensitive with high detection limits such as 2 pmol and their specificity is low.…”

Section: Discussionmentioning

confidence: 99%

Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer

2014

Asian Pacific Journal of Cancer Prevention

122

100

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“…One drawback of using LC-MS is the ineffective isomer differentiation and the inability to produce molecular ions for some flavonoids . Additional reports discuss methods used to detect polyphenolic phytoestrogens in foods and biological fluids Wilkinson et al, 2002). Other non-chromatographic methods have also been used for phytoestrogen analysis, such as immunoassay techniques, deconvolution spectroscopy and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) .…”

Section: Identification Of Phytoestrogensmentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

401

278

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Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. The number of articles published on phytoestrogens has risen dramatically in the past couple decades. Further research continues to demonstrate the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. This paper discusses the classification of phytoestrogens, methods of identification, their proposed mechanisms of action and botanical sources for phytoestrogens. The effects of phytoestrogens on breast and prostate cancers, cardiovascular disease, menopausal symptoms and osteoporosis will also be examined including research on benefits and risks.

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Identification and quantification of polyphenol phytoestrogens in foods and human biological fluids

Cited by 73 publications

References 84 publications

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer

Phytoestrogens: a review of the present state of research

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