Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

Wakf, Azza M. El; Hassan, Hanaa A.; Gharib, Nermin S.

doi:10.1007/s10616-013-9580-4

Cited by 27 publications

(24 citation statements)

References 63 publications

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“…Our results are compatible with those reported by Riggs and Melton21 who found that menopause results in elevated bone turnover, an imbalance between bone formation and bone resorption and net bone loss, and this is attributed to the cessation of ovarian function and tapering off of estrogen secretion 20–22. Also, the present work showed an increased level of serum OCN in ovariectomized rats.…”

Section: Discussionsupporting

confidence: 94%

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

El-Nabarawi¹,

Elwakd

Salem

2017

DDDT

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ObjectiveThe aim of this study was to evaluate the effect of atorvastatin on the bone formation and resorption markers in ovariectomized rats (experimental study), and to study its effect on the bone mineral density (BMD) in postmenopausal osteoporotic women (clinical study).Materials and methodsThe study involved experimental and clinical aspects. In the experimental aspect, 42 female Wistar rats were divided into five groups: Group I (n=6; sham-operated), Group II (n=6; 1 mL of carboxymethyl cellulose [CMC] was administered orally), Group III (n=6; 20 mg/kg orally of atorvastatin was administered), Group IV (n=12; untreated ovariectomized [OVX] rats and served as a model of osteoporosis [OP]) and Group V (n=12; 20 mg/kg orally of atorvastatin was administered to ovariectomized rats). After 4 weeks, serum acid phosphatase, alkaline phosphatase, osteocalcin, total calcium and inorganic phosphorus were assessed. Then, 3 µm thickness lumbar and femur sections were examined using a light microscope to assess cortical thickness, trabecular area, numbers of osteoblasts and osteoclasts. In the clinical aspect, 85 post-menopausal osteoporotic females with recently detected hyperlipidemia participated in the study. Atorvastatin 40 mg/day, calcium carbonate 500 mg/day and vitamin D 800 international units were given to all patients for a period of 18 months. BMD was measured at the start and at the end of the study by dual-energy X-ray absorptiometry (DEXA).ResultsIn the experiment aspect, the biomarkers of bone remodeling were notably elevated in the OVX group. Administration of atorvastatin produced a significant decrease in the level of these bone metabolic markers. Atorvastatin significantly ameliorates osteoporotic changes induced by ovariectomy. In the clinical aspect, after 18 months the DEXA showed improvement in the T-score for the three measured zones; however, these changes were statistically significant only in the femoral neck area.ConclusionAtorvastatin was able to decrease the rate of bone metabolism and increase osteogenic activity. It has dual mode of action; both anabolic and antiresorptive effect on bone. This lipophilic statin member may act as a double weapon drug.

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Section: Discussionsupporting

confidence: 94%

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

El-Nabarawi¹,

Elwakd

Salem

2017

DDDT

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“…Ok HM et al also found that the femoral BMD of 8-week-old ovariectomized SD rats decreased significantly following feeding with a HFD (corn oil plus lard as dietary fat source) for eight weeks [ 35 ].Our result was different from those reports, which showed that the levels of BMD and BMC in the femur and lumbar vertebra as well as the femoral Ca content and bone mass in the OVX-HFD (soybean oil plus lard as dietary fat source) group were significantly increased as compared with the OVX rats. The reason was possibly related to the soybean oil, which was rich in omega-3 fatty acids and known to have the protective effect on osteoporosis [ 36 ]. The HFDD reduced the BMD and BMC levels in the femur and lumbar vertebra, and it also reduced the femoral Ca in both the SHFDD and OVX-HFDD groups, which suggested that a HFDD aggravates bone mass loss in normal and OVX rats ( Table 3 , Fig 3B ).…”

Section: Discussionmentioning

confidence: 99%

Effects of a standard high-fat diet with or without multiple deficiencies on bone parameters in ovariectomized mature rat

et al. 2017

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The aim of this study was to determine the effects of a standard high fat diet (D12451) with or without vitamin D3, phosphorus, and calcium (i.e., high-fat diet [HFD] or high-fat deficient diet [HFDD]) on the bone parameters of ovariectomized female rats. Six-month-old of female Sprauge Dawley (SD) rats were randomly divided into six study groups: sham operation with standard chow diet (SSCD), sham operation with a HFD (SHFD), sham operation with a HFDD (SHFDD), ovariectomized (OVX), OVX with a HFD (OVX-HFD), and OVX with a HFDD (OVX-HFDD). A bilateral ovariectomy was administered to the OVX, OVX-HFD, and OVX-HFDD rats, while the SSCD, SHFD, and SHFDD rats were only given a laparotomy. Multiple analyses concerning the glucose and insulin tolerance, structure, bone strength, bone matrix, and mineralization of the rats were conducted in order to produce a detailed characterization of the effects of a HFD and a HFDD on postmenopausal osteoporotic rats. Seven months of HFD and HFDD feeding resulted in obesity and insulin resistance in female SD rats. A standard HFD increased the bone calcium content and bone strength of OVX rats. Conversely, the serum N-mid osteocalcin (N-MID-OT) and tartrate-resistant acid phosphatase (TRAP) levels in the OVX-HFDD group were increased, accompanied by a clear decrease in the bone mineral density (BMD), bone mineral content (BMC), bone calcium and bone strength, as well as reduced osteocalcin expression. A HFDD weakened the activity of the osteoblasts while aggravating bone loss and decreasing bone strength in ovariectomized rats, which may be due to the calcium, phosphorus and vitamin D3 deficiencies in the diet.

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“…[186][187][188] A recent study elucidated that soybean oil (15% w/ w) have osteoprotective effect in ovariectomized rats which restored minerals, antioxidant enzymes, antioxidant biomarkers, oxidative stress markers, inflammatory indices, and white blood cells (WBCs) count altered due to the deficiency in the estrogen hormone. [189] Moreover, isoflavone administration 2560 could ameliorate the bone turnover resorption markers more efficiently in equol producing pre-as well as post-menopausal women and, therefore, exert anabolic effect on the bones. [190] Relation between intake of isoflavones and BMD at the lumbar spine (LS) and femoral neck (FN) in different racial/ ethnic groups viz.…”

Section: Isoflavones and Osteoporosismentioning

confidence: 99%

Soy Bioactive Components in Functional Perspective: A Review

Garg

Lule

Malik

et al. 2016

International Journal of Food Properties

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Functional foods are the focus of attraction for well-being. The healthy living of Asians may be attributed to a diet enriched with soy isoflavones viz. genistein and daidzein which fills the gap of proteinaceous diet in vegetarians. Several factors, such as administration, dosage, metabolism, ingestion of other pharmacological substances, type of estrogen receptors, and presence or absence of endogenous estrogen, affect the activities and bioavailability of isoflavones. The mode of therapeutic action could be either through the stimulation of estrogen receptors or by the non-involvement of estrogen receptors. Soy, due to its isoflavones content, serves as a balanced and remedial substitute in combating various lifestyle disorders, like cancer prevention, by interruption of the breakdown of extracellular matrix that surrounds growing vessels and tumors, lowering of lipid and blood insulin levels by regulating lipid and glucose metabolism, alleviation of menopausal symptoms, and osteoprotective effects by modulating estrogen receptors, thus acting as a safer switch to hormone replacement therapy, anti-hypertensive effect which may also contribute to cardioprotective, anti-oxidative effect, regulation of cognitive functions, and many others. Therefore, it could be regarded as a valuable therapeutics. However, since soy isoflavones also act as endocrine disruptors, they also possess some negative effects. Concerns have been raised in relation to thyroid function abnormality. In view of the previously mentioned facts an attempt has been made to review the literature available on both beneficial as well as deleterious role of isoflavones, soy derived bioactive compounds.

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Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

Cited by 27 publications

References 63 publications

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study

Effects of a standard high-fat diet with or without multiple deficiencies on bone parameters in ovariectomized mature rat

Soy Bioactive Components in Functional Perspective: A Review

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