Identification and genetics of 6-thioguanine secreted by Erwinia species and its interference with the growth of other bacteria

Wensing, Annette; Gernold, M.; Jock, S.; Jansen, Rolf; Geider, Klaus

doi:10.1007/s00438-013-0805-1

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…These are prodrugs and all the enzymes involved in their activation are present in human and bacterial cells. It seems likely that impairment of purine metabolism may be related to the potent bactericidal and bacteriostatic effects of these drugs [83,87,88].…”

Section: Antimetabolitesmentioning

confidence: 99%

Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections

Soo

Kwan

Quezada

et al. 2017

CTMC

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Despite the fact that bacterial infections are one of the leading causes of death worldwide and that mortality rates are increasing at alarming rates, no new antibiotics have been produced by the pharmaceutical industry in more than a decade. The situation is so dire that the World Health Organization warned that we may enter a "post-antibiotic era" within this century; accordingly, bacteria resistant against all known antibiotics are becoming common and already producing untreatable infections. Although several novel approaches to combat bacterial infections have been proposed, they have yet to be implemented in clinical practice. Hence, we propose that a more plausible and faster approach is the utilization of drugs originally developed for other purposes besides antimicrobial activity. Among these are some anticancer molecules proven effective in vitro for eliminating recalcitrant, multidrug tolerant bacteria; some of which also protect animals from infections and recently are undergoing clinical trials. In this review, we highlight the similarities between cancer cells/tumors and bacterial infections, and present evidence that supports the utilization of some anticancer drugs, including 5-fluorouracil (5-FU), gallium (Ga) compounds, and mitomycin C, as antibacterials. Each of these drugs has some promising properties such as broad activity (all three compounds), dual antibiotic and antivirulence properties (5-FU), efficacy against multidrug resistant strains (Ga), and the ability to kill metabolically dormant persister cells which cause chronic infections (mitomycin C).

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Section: Antimetabolitesmentioning

confidence: 99%

Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections

Soo

Kwan

Quezada

et al. 2017

CTMC

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“…At 0.25 mM concentration, thioguanine completely inhibited the growth of E. coli strains B and K12. 341 This inhibition did not occur when either adenine or guanine was present in the assay medium. 338 Growth inhibition was also reported for B. subtilis, 342,343 and the abolishment of agella formation for B. cereus.…”

Section: Other Categories Of Metabolites From Pathogensmentioning

confidence: 94%

“…339 Subsequent YcfA-mediated sulfur transfer to the activated substrate generates the thioamides with concomitant release of adenosine monophosphate (AMP). 337,339 In addition to its anticancer properties, 334 thioguanine 51 is bacteriostatic towards E. coli 338 and strains of Salmonella typhimurium and Pantoea agglomerans, 341 with the resumption of cell growth aer prolonged incubation. At 0.25 mM concentration, thioguanine completely inhibited the growth of E. coli strains B and K12.…”

Section: Other Categories Of Metabolites From Pathogensmentioning

confidence: 99%

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Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)

Maglangit

Deng

2021

Nat. Prod. Rep.

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“…Based on these facts, the handling of anthrax disease in livestock needs to be developed with the utilization of endophytic bacteria-based biomaterials. The use and utilization of endophytes or microbial symbionts in neem trees can replace inefficient extraction methods, since they require large numbers of plants to be extracted on a large scale, thus causing ecological imbalances (Wensing, 2014). In addition, microbial endophytes in neem plants have the potential to resist vegetative growth of anthrax agents.…”

Section: Introductionmentioning

confidence: 99%

Screening Endophytes of Neem Leaf that Potential Anti-Anthrax through Tests of Anti Staphylococcus Aureus

et al. 2018

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Anthrax is a deadly disease caused by Bacillus antracis that damages the lymphatic and vascular systems of animals and humans. Anthrax prevention in Indonesia has been done but has many shortcomings among them is a lot of dead animal raises after vaccination and relatively expensive. The azadirachtin bioactive compound produced by neem endophytic microbes is known to inhibit the growth of B. anthracis bacteria, thus potentially as an anti-anthrax agent. Other bacteria that have the same pathogens as B. antrachis are Methycillin Resistant Staphylococcus aureus (MRSA) so that it is used as a research object. The aim of this research is to obtain the active biomaterials from selected neem leaf endophytes to be tested in S. aureus MRSA as bacteria with Anthrax pathogens. The method used in this research is the isolation, selection, and extraction of Neem endophytes. The process of isolation is done by growing on the general media and the selection process on special media. The bioactive extraction process uses 1000 rpm centrifuge and screening on MRSA culture medium. Inhibitory zone tests were used to determine the effect of endophytic biopsy in inhibiting MRSA growth. The result of the research is that the bioactive endophytes of neem are able to inhibit MRSA growth which is characterized by the formation of drag zone around the endophytic bioactive. Thus it can be concluded that the use of neem endophytes can be a new solution to eradicate the presence of anthrax disease in the livestock and people in Indonesia with safe research methods, relatively inexpensive and ineffective vaccine replacements.

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Identification and genetics of 6-thioguanine secreted by Erwinia species and its interference with the growth of other bacteria

Cited by 12 publications

References 26 publications

Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections

Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections

Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)

Screening Endophytes of Neem Leaf that Potential Anti-Anthrax through Tests of Anti Staphylococcus Aureus

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