Identification and Functional Investigation of Genome‐Encoded, Small, Secreted Peptides in Plants

Boschiero, Clarissa; Lundquist, Peter K.; Roy, Sonali; Dai, Xinbin; Zhao, Patrick Xuechun; Scheible, Wolf‐Rüdiger

doi:10.1002/cppb.20098

Cited by 17 publications

(17 citation statements)

References 73 publications

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“…Many novel genes encoding small peptides and non-coding RNAs have been identified C-TERMNAL ECODED PEPTIDES (CEP), as well as peptides containing sulfated tyrosine (PSY) (Oh et al, 2018;Ohkubo et al, 2017;Okamoto et al, 2015). CLE peptides are conserved in the plant kingdom (Boschiero et al, 2019;Fletcher, 2020;Goad et al, 2017;Whitewoods, 2020). CLE peptides are synthesized as long propeptides, which are then processed into mature peptides of 12-14 amino acids.…”

Section: Roles Of Peptides In Inter-organ and Local Dehydration Stress Signalingmentioning

confidence: 99%

“…Proteomic analyses of Arabidopsis have revealed novel small peptides predicted to function as regulatory factors in plant development and environmental responses, which are classified as members of the families CLAVATA/EMBRYO‐ SURROUNDING REGION (CLE) and C‐TERMNAL ECODED PEPTIDES (CEP), as well as peptides containing sulfated tyrosine (PSY) (Oh et al, 2018 ; Ohkubo et al, 2017 ; Okamoto et al, 2015 ). CLE peptides are conserved in the plant kingdom (Boschiero et al, 2019 ; Fletcher, 2020 ; Goad et al, 2017 ; Takahashi and Shinozaki, 2019 ; Whitewoods, 2020 ). CLE peptides are synthesized as long propeptides, which are then processed into mature peptides of 12–14 amino acids.…”

Section: Inter‐organ Signaling In Drought Responsesmentioning

confidence: 99%

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Inter‐tissue and inter‐organ signaling in drought stress response and phenotyping of drought tolerance

et al. 2021

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Plant response to drought stress includes systems for intracellular regulation of gene expression and signaling, as well as inter-tissue and inter-organ signaling, which helps entire plants acquire stress resistance. Plants sense water-deficit conditions both via the stomata of leaves and roots, and transfer water-deficit signals from roots to shoots via inter-organ signaling. Abscisic acid is an important phytohormone involved in the drought stress response and adaptation, and is synthesized mainly in vascular tissues and guard cells of leaves. In leaves, stress-induced abscisic acid is distributed to various tissues by transporters, which activates stomatal closure and expression of stress-related genes to acquire drought stress resistance. Moreover, the stepwise stress response at the whole-plant level is important for proper understanding of the physiological response to drought conditions. Drought stress is sensed by multiple types of sensors as molecular patterns of abiotic stress signals, which are transmitted via separate parallel signaling networks to induce downstream responses, including stomatal closure and synthesis of stress-related proteins and metabolites. Peptide molecules play important roles in the inter-organ signaling of dehydration from roots to shoots, as well as signaling of osmotic changes and reactive oxygen species/Ca 2+ . In this review, we have summarized recent advances in research on complex plant drought stress responses, focusing on intertissue signaling in leaves and inter-organ signaling from roots to shoots. We have discussed the mechanisms via which drought stress adaptations and resistance are acquired at the whole-plant level, and have proposed the importance of quantitative phenotyping for measuring plant growth under drought conditions.

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Section: Roles Of Peptides In Inter-organ and Local Dehydration Stress Signalingmentioning

confidence: 99%

Section: Inter‐organ Signaling In Drought Responsesmentioning

confidence: 99%

Inter‐tissue and inter‐organ signaling in drought stress response and phenotyping of drought tolerance

et al. 2021

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“…Similarly, a proteogenomic analysis identified previously unannotated peptides, which can be generated by alternative translation initiation (Zhu et al ., 2017). Detailed analyses of RNA‐sequencing data sets also revealed the existence of 4439 small coding genes in the Medicago truncatula genome (de Bang et al ., 2017; Boschiero et al ., 2019). These recently annotated genes are listed in the M. truncatula Small Secreted Peptide Database (MtSSPdb) (Boschiero et al ., 2020).…”

Section: Small Coding Genes That Mediate Environmental Stress Conditionsmentioning

confidence: 99%

Long‐distance stress and developmental signals associated with abscisic acid signaling in environmental responses

et al. 2020

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Summary Flowering plants consist of highly differentiated organs, including roots, leaves, shoots and flowers, which have specific roles: root system for water and nutrient uptake, leaves for photosynthesis and gas exchange and reproductive organs for seed production. The communication between organs through the vascular system, by which water, nutrient and signaling molecules are transported, is essential for coordinated growth and development of the whole plant, particularly under adverse conditions. Here, we highlight recent progress in understanding how signaling pathways of plant hormones are associated with long‐distance stress and developmental signals, with particular focus on environmental stress responses. In addition to the root‐to‐shoot peptide signal that induces abscisic acid accumulation in leaves under drought stress conditions, we summarize the diverse stress‐responsive peptide signals reported to date to play a role in environmental responses.

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“…In general, 30,000–40,000 protein-encoding genes have been reported in individual plant genomes 6 . Yet hundreds to thousands of SSPs are potentially overlooked in a single plant genome 7 for two reasons: (1) the SSP space is occupied by many proteins with a length of less than 100 aa 2 , 8 and (2) 50% of the discovered secreted proteins in plants do not have a known signal peptide 9 , both of which create difficulties in SSP annotation using traditional computational approaches 10 – 12 .…”

Section: Introductionmentioning

confidence: 99%

Advances and perspectives in discovery and functional analysis of small secreted proteins in plants

Hassan

et al. 2021

Hortic Res

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Small secreted proteins (SSPs) are less than 250 amino acids in length and are actively transported out of cells through conventional protein secretion pathways or unconventional protein secretion pathways. In plants, SSPs have been found to play important roles in various processes, including plant growth and development, plant response to abiotic and biotic stresses, and beneficial plant–microbe interactions. Over the past 10 years, substantial progress has been made in the identification and functional characterization of SSPs in several plant species relevant to agriculture, bioenergy, and horticulture. Yet, there are potentially a lot of SSPs that have not been discovered in plant genomes, which is largely due to limitations of existing computational algorithms. Recent advances in genomics, transcriptomics, and proteomics research, as well as the development of new computational algorithms based on machine learning, provide unprecedented capabilities for genome-wide discovery of novel SSPs in plants. In this review, we summarize known SSPs and their functions in various plant species. Then we provide an update on the computational and experimental approaches that can be used to discover new SSPs. Finally, we discuss strategies for elucidating the biological functions of SSPs in plants.

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Identification and Functional Investigation of Genome‐Encoded, Small, Secreted Peptides in Plants

Cited by 17 publications

References 73 publications

Inter‐tissue and inter‐organ signaling in drought stress response and phenotyping of drought tolerance

Inter‐tissue and inter‐organ signaling in drought stress response and phenotyping of drought tolerance

Long‐distance stress and developmental signals associated with abscisic acid signaling in environmental responses

Advances and perspectives in discovery and functional analysis of small secreted proteins in plants

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