Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

Walther, Raoul; Winther, Anna K.; Fruergaard, Anne Sofie; Akker, Wouter van den; Sørensen, Lise; Nielsen, Signe Maria; Olesen, Morten T. Jarlstad; Dai, Yitao; Jeppesen, Henrik S.; Lamagni, Paolo; Savateev, Aleksandr; Pedersen, Søren Lykke; Riber, Camilla Frich; Vigier‐Carrière, Cécile; Lock, Nina; Singh, Mandeep; Bansal, Vipul; Zelikin, Alexander N.

doi:10.1002/ange.201812668

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…This suggests that the surface charge of the nanozyme is not the only factor that governs the ability of a nanozyme to oxidize different substrates. One such factor was recently pointed out where the catalytic activity of nanozymes was suggested to be dependent on their ability to cleave the leaving group in the substrates [ 29 ]. This suggests that there is a complex interplay between the substrate leaving group, the surface charge, and the inherent property of the nanomaterial in dictating the ability of a nanozyme to oxidize different substrates.…”

Section: Resultsmentioning

confidence: 99%

“…In the case of temporary inhibition, the inhibitor molecule binds reversibly to an enzyme (non-covalent interaction) such that it either temporarily inhibits or slows down the catalytic rate. In contrast, irreversible inhibitors bind covalently to the enzyme and permanently block its activity [ 29 ]. It is important to note that in the context of nanozymes, the only type of inhibition reported to date is reversible inhibition [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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L-Cysteine as an Irreversible Inhibitor of the Peroxidase-Mimic Catalytic Activity of 2-Dimensional Ni-Based Nanozymes

et al. 2021

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The ability to modulate the catalytic activity of inorganic nanozymes is of high interest. In particular, understanding the interactions of inhibitor molecules with nanozymes can bring them one step closer to the natural enzymes and has thus started to attract intense interest. To date, a few reversible inhibitors of the nanozyme activity have been reported. However, there are no reports of irreversible inhibitor molecules that can permanently inhibit the activity of nanozymes. In the current work, we show the ability of L-cysteine to act as an irreversible inhibitor to permanently block the nanozyme activity of 2-dimensional (2D) NiO nanosheets. Determination of the steady state kinetic parameters allowed us to obtain mechanistic insights into the catalytic inhibition process. Further, based on the irreversible catalytic inhibition capability of L-cysteine, we demonstrate a highly specific sensor for the detection of this biologically important molecule.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

L-Cysteine as an Irreversible Inhibitor of the Peroxidase-Mimic Catalytic Activity of 2-Dimensional Ni-Based Nanozymes

et al. 2021

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“…In 2007, GAO et al discovered that magnetite (Fe 3 O 4 ) nanoparticles had a special property that similar to HRP [ 6 ]. Since then, a series of nanomaterials have been unraveled to serve as POD mimics, including metal materials [ 181 ], metal oxides [ 182 ], conducting polymers [ 183 ], metal organic frameworks [ 184 ], carbon nanomaterials [ 185 ], single-atom catalysts [ 186 ] and so on.…”

Section: Properties Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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“…Nanoparticles in the role of enzymes (nanozymes) open up a completely new view on the origin of life theory. The enzymatic activity of inorganic materials has begun to be recognized in the context of new theories of the origin of life [ 13 , 14 ]. Many theories, such as the Metabolism-first world [ 15 ], Zinc world [ 16 ], Thioester world [ 17 ], RNA world [ 18 ] and others [ 19 ], are currently being proposed as possible explanations for the origins of life.…”

Section: Introductionmentioning

confidence: 99%

UV-Induced Nanoparticles-Formation, Properties and Their Potential Role in Origin of Life

et al. 2020

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Inorganic nanoparticles might have played a vital role in the transition from inorganic chemistry to self-sustaining living systems. Such transition may have been triggered or controlled by processes requiring not only versatile catalysts but also suitable reaction surfaces. Here, experimental results showing that multicolor quantum dots might have been able to participate as catalysts in several specific and nonspecific reactions, relevant to the prebiotic chemistry are demonstrated. A very fast and easy UV-induced formation of ZnCd quantum dots (QDs) with a quantum yield of up to 47% was shown to occur 5 min after UV exposure of the solution containing Zn(II) and Cd(II) in the presence of a thiol capping agent. In addition to QDs formation, xanthine activity was observed in the solution. The role of solar radiation to induce ZnCd QDs formation was replicated during a stratospheric balloon flight.

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Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

Abstract: Identification and directed development of non-organic catalysts with apparent pan-enzymatic mimicry into nanozymes for efficient prodrug conversion

Cited by 11 publications

References 25 publications

L-Cysteine as an Irreversible Inhibitor of the Peroxidase-Mimic Catalytic Activity of 2-Dimensional Ni-Based Nanozymes

L-Cysteine as an Irreversible Inhibitor of the Peroxidase-Mimic Catalytic Activity of 2-Dimensional Ni-Based Nanozymes

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

UV-Induced Nanoparticles-Formation, Properties and Their Potential Role in Origin of Life

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