Identification and characterization of DPP-IV inhibitory peptides from silver carp swim bladder hydrolysates

Hong, Hui; Zheng, Yanyan; Song, Sijia; Zhang, Yuqi; Zhang, Chi; Liu, Jun; Luo, Yongkang

doi:10.1016/j.fbio.2020.100748

Cited by 42 publications

(24 citation statements)

References 32 publications

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“…The most potent peptide WGDEHIPGSPYH inhibited DPP IV in an uncompetitive manner and docking analysis indicated that the peptide bound close to the catalytic site of the enzyme. Furthermore, this peptide and its hydrolysate IPGSPY exhibited strong DPP IV inhibition and promoted insulin secretion in Caco-2 cells [77]. Three peptides, PGVGGPLGPIGPCYE, CAYQWQRPVDRIR, and PACGGFWISGRPG, that produced in vitro DPP IV inhibitory activity with IC 50 of 116.1, 78.0 and 96.4 µM, respectively, were identified from tuna cooking juice [78].…”

Section: Fish Productsmentioning

confidence: 94%

“…Several milk protein hydrolysates and peptides with antidiabetic activity have been identified from cow, donkey, goat, and camel sources [52][53][54]56]. Other food sources such as egg, meat, pulse, and fish proteins could also potentially contribute antidiabetic peptides [64,72,77]. Interestingly, structure-activity relationship studies have shown that the presence of specific amino acids, as well as their position, could influence DPP IV inhibitory activity.…”

Section: Structural Characteristics Of Antidiabetic Peptides From Foodmentioning

confidence: 99%

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Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review

Antony

Vijayan

2021

IJMS

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Diabetes mellitus is a major public health concern associated with high mortality and reduced life expectancy. The alarming rise in the prevalence of diabetes is linked to several factors including sedentary lifestyle and unhealthy diet. Nutritional intervention and increased physical activity could significantly contribute to bringing this under control. Food-derived bioactive peptides and protein hydrolysates have been associated with a number health benefits. Several peptides with antidiabetic potential have been identified that could decrease blood glucose level, improve insulin uptake and inhibit key enzymes involved in the development and progression of diabetes. Dietary proteins, from a wide range of food, are rich sources of antidiabetic peptides. Thus, there are a number of benefits in studying peptides obtained from food sources to develop nutraceuticals. A deeper understanding of the underlying molecular mechanisms of these peptides will assist in the development of new peptide-based therapeutics. Despite this, a comprehensive analysis of the antidiabetic properties of bioactive peptides derived from various food sources is still lacking. Here, we review the recent literature on food-derived bioactive peptides possessing antidiabetic activity. The focus is on the effectiveness of these peptides as evidenced by in vitro and in vivo studies. Finally, we discuss future prospects of peptide-based drugs for the treatment of diabetes.

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Section: Fish Productsmentioning

confidence: 94%

Section: Structural Characteristics Of Antidiabetic Peptides From Foodmentioning

confidence: 99%

Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review

Antony

Vijayan

2021

IJMS

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“…The peptide sequence was identified using LC‐MS/MS as described by Hong et al., (2020) with minor modifications. First, the system was equilibrated through 95% of the A solution (0.1% formic acid aqueous solution).…”

Section: Methodsmentioning

confidence: 99%

Purification, identification, and molecular mechanism of DPP‐IV inhibitory peptides from defatted Antarctic krill powder

Lang

Song

et al. 2021

J Food Biochem

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Dipeptidyl peptidase‐IV (DPP‐IV) inhibitors can reduce the blood sugar levels of diabetic patients by preventing the rapid decomposition of incretin hormone and prolonging its physiological effects. In this study, DPP‐IV inhibitory peptides FAGDDAPR and LAPPRGSL were isolated from defatted Antarctic krill powder (DAKP) protein by the sequential purification of ultrafiltration, gel filtration chromatography, and RP‐HPLC, and IC50 values of the two peptides were 349.70 ± 3.66 μM and 461.14 ± 0.87 μM, respectively. The FAGDDAPR and LAPPRGSL were identified by LC‐MS/MS method, and the molecular models of DPP‐IV and the two peptides were further constructed by AutoDock Vina software, the results revealed that the inhibition activity of FAGDDAPR and LAPPRGSL was mainly attributed to the formation of strong hydrophobic interactions and hydrogen bonds with amino acids of DPP‐IV. Practical applications DAKP is an economical by‐product produced in the production of krill oil and contains high‐quality protein, but these products were mainly used as fish feed and had low utility value in the past. DPP‐IV inhibitors are an efficacious drug employed in the treatment of hyperglycemia processes. However, these drugs can cause undesirable side effects. Thus, the development of new natural hypoglycemic drugs with low side effects is a valuable strategy to be applied in therapeutic interventions.

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“…Drotningsvik et al obtained similar outcomes in their study of salmon hydrolysates [ 85 ]. Sea cucumber ( Holothuria Nobilis ) hydrolysates showed insulin-sensitizing effects in streptozotocin (STZ) and high-fat diet (HFD)-induced diabetic rats [ 86 ] while silver carp swim bladder hydrolysates inhibited dipeptidyl peptidase IV (DPP-IV) activity and enhanced insulin secretion in vitro [ 87 ]. In addition, the hyperglycemic effects of chicken-liver hydrolysates [ 83 ] and camel-milk hydrolysates are illustrated by a glucose tolerance test [ 88 ].…”

Section: Bioactive Ingredient Of Nutraceuticalsmentioning

confidence: 99%

Trends and applications of food protein-origin hydrolysates and bioactive peptides

Wu¹,

Chen²

2022

Journal of Food and Drug Analysis

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It was reported that protein hydrolysates or derived peptides have more functionalities than their parent protein. Most functional protein hydrolysates or peptides are identified from various food products, including plant, fish, and land-animal protein sources. Within a few decades, the application of food protein-origin functional hydrolysates or peptides could be divided into two main categories according to their applied intentions: 1) preservatives and bioactive packing materials; 2) nutraceutical ingredients. According to the literature, the applications of food protein-origin functional hydrolysates or peptides on food preservative and nutraceutical ingredients have attracted much attention. However, the approach method should be changed. Multi-activities, compound formulation, comprehensive evaluation, and the added value of by-products are possible strategies. Although there have been great results and findings in the functionalities of food protein-origin bioactive hydrolysates or peptides, there is still a big gap between the lab-scale results and practical applications. Via this narrative review on the current research, scientists, the food/health industry, and government authorities should cooperate to dig into the new material sources and the possible practical application.

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Identification and characterization of DPP-IV inhibitory peptides from silver carp swim bladder hydrolysates

Cited by 42 publications

References 32 publications

Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review

Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review

Purification, identification, and molecular mechanism of DPP‐IV inhibitory peptides from defatted Antarctic krill powder

Trends and applications of food protein-origin hydrolysates and bioactive peptides

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