Trends and applications of food protein-origin hydrolysates and bioactive peptides

Abstract

It was reported that protein hydrolysates or derived peptides have more functionalities than their parent protein. Most functional protein hydrolysates or peptides are identified from various food products, including plant, fish, and land-animal protein sources. Within a few decades, the application of food protein-origin functional hydrolysates or peptides could be divided into two main categories according to their applied intentions: 1) preservatives and bioactive packing materials; 2) nutraceutical ingredients. According to the literature, the applications of food protein-origin functional hydrolysates or peptides on food preservative and nutraceutical ingredients have attracted much attention. However, the approach method should be changed. Multi-activities, compound formulation, comprehensive evaluation, and the added value of by-products are possible strategies. Although there have been great results and findings in the functionalities of food protein-origin bioactive hydrolysates or peptides, there is still a big gap between the lab-scale results and practical applications. Via this narrative review on the current research, scientists, the food/health industry, and government authorities should cooperate to dig into the new material sources and the possible practical application.

A functional chicken‐liver hydrolysate‐based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti‐inflammation, and antiapoptosis

“…Based on the agricultural circular economy action plan ("AgroCycle"), protein hydrolysates could offer an alternative application of animal by-products in the nutraceutical or pharmacological industry. 2 Our team has successfully developed a functional CLH, which is characterized by the antioxidant effect in D-galactose induced mice, 4 the lipid-lowering effect in high-fat/cholesterol-diet fed hamsters (8-week experiment) 23 and long-term high-fat-diet fed mice (20-week experiment). 24 In addition, CLH is the major ingredient in GBHP01™, which has recently been proven as a hepatoprotection against liver fibrogenesis.…”

“…Nutraceuticals and pharmaceuticals are also involved in the AgroCycle innovation chain. It was reported that protein hydrolyzation offers a feasible application of animal by‐products, which usually contain abundant proteins such as feathers, blood, viscera, and skin 2 . Regarding the commercial possibility of novel nutraceutical development, the candidates of ingredients should be either effective or low‐cost.…”

“…Recently, food‐derived protein hydrolysates have been demonstrated to own several biofunctionalities like antioxidant, 4 cardioprotection, 5–7 hepatoprotection, 8–10 reproductive function, 11 and antihypertension 12 etc. It has been reported that biofunctionalities of protein hydrolysates or peptides mainly result from their amino acid composition or peptides with specific sequences and structures 2 …”

“…It has been reported that biofunctionalities of protein hydrolysates or peptides mainly result from their amino acid composition or peptides with specific sequences and structures. 2 Due to the available vaccines of hepatitis A and B, as well as the COVID-19 outbreak, it was the first time that the liver-related disease has dropped from the list of the 10 leading causes of death in Taiwan since 2022. 13 However, the cancers of liver and intrahepatic bile ducts are still listed in Taiwan's top 10 leading cancer causes of death.…”

A review of bioactive peptides as functional food ingredients: mechanisms of action and their applications in active packaging and food quality improvement

“…4 Depending on its biological activity, the mode of action differs. 5,6 They might then be included as functional ingredients, where their bioactivity could help with illness prevention and control as well as improve quality of life. 7,8 The worldwide market for peptide drugs expanded from $14.1 billion in 2011 to over USD 33.58 billion in 2021 in terms of value.…”