Identification and Characterization of CEPU-Se—A Secreted Isoform of the IgLON Family Protein, CEPU-1

Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis

“…[37][38][39][40][41][42][43][44][45][46][47][48] The principal differentially expressed genes upregulated in neurothekeomas and cellular fibrous histiocytomas over nerve sheath myxomas and schwannomas consisted of those encoding various metalloproteinases and glycoproteins. These genes are involved in extracellular matrix growth and remodeling, and cell adhesion in fibroblasts and macrophages (Table 6).…”

Diglons are heterodimeric proteins composed of IgLON subunits, and Diglon-CO inhibits neurite outgrowth from cerebellar granule cells

“…α1LAMP-Fc, α2OBCAM-Fc and α2βCEPU-1-Fc (GenBank accession numbers for the respective IgLON sequences are Q98919, Q98892 and Q90773) were prepared either from stably transfected J558L mouse myeloma cells as described previously or from calciumphosphate-mediated transient transfection of HEK 293 human embryonic kidney cells, using methods described elsewhere (Chen and Okayama, 1988). CHO cell lines stably expressing cell surface α1LAMP, α2OBCAM, α2βCEPU-1 and α2CEPU-1 were prepared and cultured as described previously (Lodge et al, 2001).…”

“…In some cases, little or no response has been observed and, in others, moderate enhancement or inhibition has been seen (Gil et al, 1998;Hancox et al, 1997;Lodge et al, 2001;Mann et al, 1998;Marg et al, 1999;McNamee et al, 2002). Interestingly, the most striking results were obtained with GP55, a glycoprotein isolated from adult brain that contains a mixture of all members of the IgLON family (Clarke and Moss, 1994).…”

Function of alternative splicing

“…The soluble forms can influence this multimerization. Neurite outgrowth (Lodge et al, 2001) and inhibin actions are influenced by this mechanism (Bernard and Woodruff, 2001). Some transmembrane proteins, e.g., the flt3 ligand are activated by proteolytic cleavage.…”