Identification and Bioactivity of Compounds from the Fungus Penicillium sp. CYE-87 Isolated from a Marine Tunicate

Shaala, Lamiaa A.; Youssef, Diaa T. A.

doi:10.3390/md13041698

Cited by 47 publications

(33 citation statements)

References 24 publications

(29 reference statements)

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“…Marine tunicates were potential for inoculum source for endo-symbiotic that can produce anti-bacterial and anti-fungi (Karthikeyan et al 2009;Litaay et al 2015;Christine et al 2015;Nurfadillah et al 2015;Sardiani et al 2015;Tahir et al 2016). Tunicates are also potential antiviral (Murti and Agrawal, 2010), anticancer (Shaala and Youssef, 2015), inhibitor and induces apoptosis of breast (MCF-7; MDA-MB) cancer cells and also used for phase II cancer treatment (Zelek et al 2006;Michaelson et al 2012;Atmaca et al 2013), as inhibitor of breast cancer cells by JNK dependent apoptosis (Gonzalez-Santiago et al 2006), breast and prostate cancer (Kalimuthu et al 2014). One of the bioactive compounds produced by tunicate is used to cure refractory soft-tissue sarcomas (Sinko et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Biodiversity of Marine Tunicates in Samalona Waters, Sangkarang Archipelago, Indonesia

Litaay¹,

Santosa²,

Johannes³

et al. 2018

JIKS

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The study aims to know the biodiversity and community structure of marine tunicate in Samalona waters. The present study is part of biodiversity assessment for marine resources of Sangkarang Archipelago SW Makassar Indonesia. Field campaign was conducted from October to November 2016. Sample collection was done at 3 and 7 m depth by using Line Intersection Transect (LIT) method combined with a quadrat (plot). Two 50 m transects were placed parallel to a shore line at three stations (sta.) at Samalona waters. A quadrat (plot) (2.5 m x 2.5 m) was placed side by side of the line transect and all tunicates in the transect was recorded, identified, counted and photographed. Samples were collected by using SCUBA and under water camera. Environmental parameters including water temperatue, salinity, dissolved oxygen, clarity, current and wind speed, were measured in situ. Data were analysed using ecological indices including species composition and density, Shanon Wienner species diversity, Evenness, and Morisita Indices. The result indicates that there are 18 species of tunicates present at 3 m as well as 7 m depth of Samalona waters.. Result of the ecological analysis shows that species diversity can be categorized as moderate and there were no dominant species. Environmental parameters indicates that water quality at Samalona waters was in good condition to support tunicates.

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Section: Introductionmentioning

confidence: 99%

Biodiversity of Marine Tunicates in Samalona Waters, Sangkarang Archipelago, Indonesia

Litaay¹,

Santosa²,

Johannes³

et al. 2018

JIKS

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“…[53]; a new C24-acetylenic acid, biemnic acid (MIC = 100 µg/disk) isolated from the Red sea sponge Biemna ehrenbergi [148]; two sulfated steroid-aminoacid conjugates isolated from the Irish marine sponge Polymastia boletiformis (MIC = 100 µg/disk) against C. albicans [149]; two novel lysophospholids from the Guanxi sponge S. purpurea (IC 50 = 16 and 32 µg/mL) [84]; two new bromotyrosine alkaloids, tyrokeradine G and H, isolated from an Okinawan Verongid marine sponge (MIC = 16 and 32 µg/mL) [150]; two highly brominated polyphenols isolated from the Qingdao red alga S. latiuscula (MIC = 12.5, 25 µg/mL) [151]; one novel anhydride metabolite, tubingenoic anhydride A (MIC = 330 µM), from the Mediterranean fungus A. tubingensis (Strain OY907) [152]; and a novel compound terretrione D (MIC = 32 µg/mL) from a tunicate-derived fungus Penicillium sp. CYE-97 [153]. These novel marine compounds may contribute to the antifungal preclinical and clinical pipeline upon further research.…”

Section: Antifungal Activitymentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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“…There are also reports regarding the bioactivities of compounds isolated from the ascidian Didemnum sp.-derived fungus Penicillium sp. CYE-87, which shows antimigratory and antiproliferation activity against several human cancer cell lines [149,150]. The fungus Aspergillus sp.…”

Section: Fungimentioning

confidence: 99%

Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

Dou

Dong

2019

Marine Drugs

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Marine ascidians are becoming important drug sources that provide abundant secondary metabolites with novel structures and high bioactivities. As one of the most chemically prolific marine animals, more than 1200 inspirational natural products, such as alkaloids, peptides, and polyketides, with intricate and novel chemical structures have been identified from ascidians. Some of them have been successfully developed as lead compounds or highly efficient drugs. Although numerous compounds that exist in ascidians have been structurally and functionally identified, their origins are not clear. Interestingly, growing evidence has shown that these natural products not only come from ascidians, but they also originate from symbiotic microbes. This review classifies the identified natural products from ascidians and the associated symbionts. Then, we discuss the diversity of ascidian symbiotic microbe communities, which synthesize diverse natural products that are beneficial for the hosts. Identification of the complex interactions between the symbiont and the host is a useful approach to discovering ways that direct the biosynthesis of novel bioactive compounds with pharmaceutical potentials.

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Identification and Bioactivity of Compounds from the Fungus Penicillium sp. CYE-87 Isolated from a Marine Tunicate

Cited by 47 publications

References 24 publications

Biodiversity of Marine Tunicates in Samalona Waters, Sangkarang Archipelago, Indonesia

Biodiversity of Marine Tunicates in Samalona Waters, Sangkarang Archipelago, Indonesia

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

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