Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: In vitro evaluation

Montenegro, Lucía; Sinico, Chiara; Castangia, Inés; Carbone, Claudia; Puglisi, Giovanni

doi:10.1016/j.ijpharm.2012.05.046

Cited by 85 publications

(75 citation statements)

References 30 publications

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“…45 The DSC evaluation of the LCNPs showed a main peak at 35°C, which is lower than the melting peaks of excipients ( Figure 5 and S2). As reported by Montenegro et al, 46 the melting peak of cetyl palmitate could be lower than the peak of the cetyl palmitate bulk. This lower melting point could be attributed to the nano-size of the particles and the non-crystallized, super-cooled state of the core of the LCNPs.…”

Section: Discussionsupporting

confidence: 54%

“…This lower melting point could be attributed to the nano-size of the particles and the non-crystallized, super-cooled state of the core of the LCNPs. 46,47 The state of tetradecyl tetradecanoate in the LCNP layer in this study was nano-sized and could also be the super-cooled form resulting from the rapid cooling process. This phenomenon may explain the decrease in the melting point.…”

Section: Discussionmentioning

confidence: 82%

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Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Lee¹,

Park²,

Bae³

et al. 2016

IJN

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Liquid crystal nanoparticles have been utilized as an efficient tool for drug delivery with enhanced bioavailability, drug stability, and targeted drug delivery. However, the high energy requirements and the high cost of the liquid crystal preparation have been obstacles to their widespread use in the pharmaceutical industry. In this study, we prepared liquid crystal nanoparticles using a phase-inversion temperature method, which is a uniquely low energy process. Particles prepared with the above method were estimated to be ~100 nm in size and exhibited a lamellar liquid crystal structure with orthorhombic lateral packing. Pharmacokinetic and tissue distribution studies of a hydrophobic peptide-based drug candidate formulated with the liquid crystal nanoparticles showed a five-fold enhancement of bioavailability, sustained release, and liver-specific drug delivery compared to a host–guest complex formulation.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 82%

Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Lee¹,

Park²,

Bae³

et al. 2016

IJN

View full text Add to dashboard Cite

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“…The samples were firstly negatively stained using 2% uranyl acetate (w/v), followed by air drying for 15 min and then the excess was removed by filter paper. 28 ee% determination EE% was examined by measuring the amount of free drug in the aqueous phase after separation of the system using the International Journal of Nanomedicine 2018:13 submit your manuscript | www.dovepress.com…”

Section: Morphological Analysismentioning

confidence: 99%

Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study

Badawi¹,

Teaima²,

El-Say³

et al. 2018

IJN

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Background Pomegranate extract (PE) is a natural product with potent antioxidant and anticancer activity because of its polyphenols content. The main purpose of this study was to maximize the PE chemotherapeutic efficacy by loading it in an optimized solid lipid nanoparticles (SLNs) formula. Materials and methods The influence of independent variables, which were lipid concentration (X 1 ), surfactant concentration (X 2 ) and cosurfactant concentration (X 3 ), on dependent ones, which were particle size (Y 1 ), polydispersity index (Y 2 ), zeta potential (Y 3 ), entrapment efficiency (Y 4 ) and cumulative % drug release (Y 5 ), were studied and optimized using the Box–Behnken design. Fifteen formulations of PE-SLNs were prepared using hot homogenization followed by ultra-sonication technique. Response surface plots, Pareto charts and mathematical equations were produced to study the impact of independent variables on the dependent quality parameters. The anti-proliferative activity of the optimized formula was then evaluated in three different cancer cell lines, namely, MCF-7, PC-3 and HepG-2, in addition to one normal cell line, HFB-4. Results The results demonstrated that the particle sizes ranged from 407.5 to 651.9 nm and the entrapment efficiencies ranged from 56.02 to 65.23%. Interestingly, the 50% inhibitory concentration of the optimized formula had more than a 40-fold improved effect on the cell growth inhibition in comparison with its free counterpart. Furthermore, it was more selective against cancer cells than normal cells particularly in MCF-7 breast cancer cells. Conclusion These data proved that nanoencapsulation of PE enhanced its anticancer efficacy. Therefore, our results suggested that a PE-loaded SLNs optimized-formula could be a promising chemo therapeutic agent.

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“…However, the melting peak for the CRM was not detected in the thermograms of the lyophilized CRM-NLCs. The disappearance of the endothermic peak of CRM in the CRM-NLCs powder suggests that the drug was molecularly dispersed in the lipid matrix and converted to an amorphous state from the crystalline state (Montenegro et al, 2011). …”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study

2014

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Cancer nanotherapeutics is beginning to overwhelm the global research and viewed to be the revolutionary treatment regime in the medical field. This investigation describes the development of a stable nanostructured lipid carrier (NLC) system as a carrier for curcumin (CRM). The CRM-loaded NLC developed as a particle with the size of 146.8 nm, a polydispersity index of 0.18, an entrapment efficiency (EE) of 90.86%, and the zeta potential (ZP) of À21.4 mV. Besides, the increased cytotoxicity of CRM-NLC than that of CRM to astrocytoma-glioblastoma cell line (U373MG) in the cancer cell lines was observed. Results of biodistribution studies showed higher drug concentration in brain after intranasal administration of NLCs than PDS. The results of the study also suggest that CRM-NLC is a promising drug delivery system for brain cancer therapy. KeywordsCurcumin, nanostructured lipid carrier, nasal drug delivery History

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Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: In vitro evaluation

Cited by 85 publications

References 30 publications

Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study

Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study

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