Id: 162

Moll, Jens M.; Wehmöller, Melanie; Homey, Lisa; Frank, Nils Christopher; Baran, Paul; Garbers, Christoph; Axelrod, Jonathan H.; Galun, Eithan; Mootz, Henning D.; Scheller, Jürgen

doi:10.1016/j.cyto.2015.08.180

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2021

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“…Especially IL-11-mediated effects have to be considered, since IL-11, like IL-6, forms a ternary complex composed of cytokine, α-receptor and gp130, leading to gp130 dimerization and subsequent signal transduction. sgp130Fc is a potent inhibitor of IL-11 transand cluster-signaling (13,18,46). Consequently, the dissection of IL-6 and IL-11 trans-signaling effects by sgp130Fc is a complicated endeavor.…”

Section: Discussionmentioning

confidence: 99%

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T _H 17 cell expansion

et al. 2021

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The cytokine IL-6 performs critical functions in various tissue types but is implicated in autoimmune disease. Therefore, precisely targeting the pathway by which IL-6 induces inflammatory immune cell activation could leave other signaling pathways and functions of IL-6 intact. Currently, such targeted molecules lack sufficient selectivity. Heise et al. developed a chimeric molecule that bound to and "trapped" a critical IL-6 trans-signaling protein complex and that was smaller, had greater selectivity for the IL-6 complex over a similar IL-11 complex, and more effectively inhibited the IL-6-induced inflammatory activation of cultured T cells. These findings may lead to improved therapeutics for patients with autoimmune disease.

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Section: Discussionmentioning

confidence: 99%

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T _H 17 cell expansion

et al. 2021

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Id: 162

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Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T _H 17 cell expansion

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T _H 17 cell expansion

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Id: 162

Cited by 1 publication

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Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion

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Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T _H 17 cell expansion

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T _H 17 cell expansion